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Pharmacological Properties

  • Chapter
Organic Nitrates

Abstract

The most prominent pharmacologic effects of the nitrate-nitrite drugs are manifested on the vasculature; the small blood vessels, arterioles, capillaries, and venules. The details of these actions and the response of the cardiovascular system will be considered in this chapter. Other pharmacologic properties include actions on bronchial smooth muscle and cardiovascular enzyme systems.

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References

  • Anderson, F.F., Craver, B.N.: A pyrex apparatus for the perfusion of the coronary circulation of mammalian hearts. J. Pharmacol. exp. Ther. 93, 135–141 (1948).

    PubMed  CAS  Google Scholar 

  • Arborelius, M., Lecerof, H., Malm, A., Malmborg, R.O.: Acute effect of nitroglycerin on haemodynamics of angina pectoris. Brit. Heart J. 30, 407–411 (1968).

    Article  PubMed  Google Scholar 

  • Aviado, D. M.: The lung circulation. Oxford: Pergamon Press 1965.

    Google Scholar 

  • Aviado, D.M., Folle, L. E., Bellet, S.: Cardiopulmonary effects of glyceryl trinitrate and isosorbide dinitrate. Cardiologia (Basel) 52, 287–303 (1968 a).

    CAS  Google Scholar 

  • Aviado, D. M., Ito, H., Cho, Y. W., Bellet, S.: Coronary vasodilators on myocardial oxygen consumption and ammonia production. Cardiologia (Basel) 53, 27–46 (1968 b).

    CAS  Google Scholar 

  • Aviado, D.M., Kishimoto, T., Kneidinger, H.J.: Bronchopulmonary effects of pentaerythrityl tetranitrate and isoproterenol. J. Pharmacol. exp. Ther. 165, 274–285 (1969).

    PubMed  CAS  Google Scholar 

  • Barbour, H.G., Prince, A. L.: The perfused isolated rabbit heart. J. exp. Med. 21, 330–338 (1915).

    Article  PubMed  CAS  Google Scholar 

  • Barlow, O.W., Beams, A.J.: A comparison of the bronchodilating action of several anti-asthmatic agents after anaphylactic and histamine shock in the guinea pig. J. Pharmacol. exp. Ther. 47, 111–130(1933).

    CAS  Google Scholar 

  • Becker, L.C., Fortuin, N.J., Pitt, B.: Effects of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle. Circulation Res. 28, 263–269 (1971).

    PubMed  CAS  Google Scholar 

  • Bernstein, L., Friesinger, G.C., Lichtlen, P.R., Ross, R.S.: The effect of nitroglycerin on the systemic and coronary circulation in man and dogs. Circulation 33, 107–116 (1966).

    PubMed  CAS  Google Scholar 

  • Berry, J. W., Roach, T.C.: An evaluation of blood nitrate levels. Circulation 17, 1014–1046 (1958).

    Google Scholar 

  • Bing, R. J.: Cardiac metabolism. Physiol. Rev. 45, 171–213 (1965).

    PubMed  CAS  Google Scholar 

  • Bing, R. J., Bennish, A., Bluemchen, G., Coehen, A., Gallagher, J. P., Zaleski, E. J.: The determination of coronary flow equivalent with coincidence counting technique. Circulation 29, 833–846 (1964).

    PubMed  CAS  Google Scholar 

  • Bing, R. J., Cowan, C., Bottcher, D., Corsini, G., Daniels, C. G.: A new method of measuring coronary blood flow in man. J. Amer. med. Ass. 205, 277–280 (1968).

    Article  CAS  Google Scholar 

  • Bogaert, M. G.: Organic nitrates in angina pectoris. Arch. int. Pharmacodyn. Ther. 196, 25–34 (1972).

    PubMed  Google Scholar 

  • Bogaert, M.G., Rosseel, M.T., DeSchaepdryver, A.F.: The metabolic fate of nitroglycerin (trinitrin) in relation to its vascular effects. Europ. J. Pharmacol. 12, 224–230 (1970).

    Article  CAS  Google Scholar 

  • Brachfeld, N., Bozer, J., Gorlin, R.: Action of nitroglycerin on the coronary circulation in normal and mild cardiac subjects. Circulation 19, 697–704 (1959).

    PubMed  CAS  Google Scholar 

  • Brandt, J.L., Coccesse, A., Dock, W.: Slitkymographic evidence that nitroglycerine decreases heart volume and stroke volume while increasing amplitude of ballistocardiographic waves. Amer. J. Med. 12, 650–658 (1952).

    Article  PubMed  CAS  Google Scholar 

  • Bretschneider, H.J., Frank, A., Bernard, I., Kochseik, K., Scheler, F.: Die Wirkung eines Pyrimidopyrimidin-Derivates auf die Sauerstoffversorgung des Herzmuskels. Arzneimittel-Forsch. 9, 49–59 (1959).

    CAS  Google Scholar 

  • Brunton, T.L.: On the use of nitrite of amyl in angina pectoris. Lancet 1867II, 97–98.

    Article  Google Scholar 

  • Carr, C.J.: The pharmacology of the vasodilator nitrate-nitrite drugs. Int. Rec. Med. 171, 121–129 (1958).

    CAS  Google Scholar 

  • Carr, C.J., Bell, F.K., Bradyhouse, M.F., Krantz, J.C., Jr.: Effect of vasodilators upon the dephosphorylating enzymes of dogs’ coronary arteries. J. Pharmacol. exp. Ther. 108, 385–392 (1953).

    PubMed  CAS  Google Scholar 

  • Carr, C.J., Burgison, R.M., Fassell, M.S., Krantz, J.C. Jr.: Alkyl nitrites XVI. Comparative depressor responses of octyl nitrite and glyceryl trinitrate. Proc. Soc. exp. Biol. (N.Y.) 76, 759–760(1951).

    CAS  Google Scholar 

  • Otters, R.L., Van: Physiology and biophysics, p.690. Theodore C. Ruch and Harry D. Patton, (Eds.). Philadelphia, Pa: W. B. Saunders Co. 1966.

    Google Scholar 

  • Cohen, A., Gallagher, J.P., Luebs, E.D., Varga, Z., Yamanaka, J., Zaleski, E.J., Bluemchen, C., Bing, R.J.: The quantitative determination of coronary flow with a positron emitter (rubidium 84). Circulation 32, 636–649 (1965).

    PubMed  CAS  Google Scholar 

  • Cuny, L., Quivy, D.: Action vaso-dilatatrice de la trinitrine, etudieé par la Plethysmographie de la muqueuse nasale. C.R. Soc. Biol. (Paris) 136, 283–284 (1942).

    CAS  Google Scholar 

  • Darby, T.D., Aldinger, E.E.: Further studies of the effect on myocardial energy utilization elicited by nitroglycerin. Circulation Res. 8, 100–108 (1960).

    PubMed  CAS  Google Scholar 

  • Davidson, I.W.F., Miller, H.S., DiCarlo, F.J.: Absorption, excretion and metabolism of pentaerythritol tetranitrate by humans. J. Pharmacol. exp. Ther. 175, 42–50 (1970).

    PubMed  CAS  Google Scholar 

  • Davidson, I.W.F., Miller, H.S., DiCarlo, F.J.: Pharmacodynamics and biotransformation of pentaerythritol tetranitrate in man. J. Pharm. Sci. 60, 274–277 (1971).

    Article  PubMed  CAS  Google Scholar 

  • DeMaria, A.N., Vismara, L.A., Auditore, K., Amsterdam, E.A., Zelis, R., Mason, D.T.: Effects of nitroglycerin on left ventricular cavity size and cardiac performance determined by ultrasound in man. Amer. Soc. Clin. Pharmacol. Ther. 1974 meeting abstract. Clin. Pharmacol. Ther. 15, 204(1974).

    Google Scholar 

  • DiCarlo, F.J., Coutinko, C.B., Crew, M.C.: Sites of absorption of pentaerythritol tetranitrate. Arch. Int. Pharmacodyn. Ther. 167, 163–170 (1967).

    Google Scholar 

  • Domenech, R.J., Hoffman, J.I.E., Noble, M.I.M., Saunders, K.B., Henson, J.R., SubijAnto, S.: Total and regional coronary blood flow measured by radioactive microspheres in consicious and anesthetized dogs. Circulation Res. 25, 581–596 (1969).

    PubMed  CAS  Google Scholar 

  • Dresdale, D.T., Yuceoglu, Y.Z., Reyes, A., Jr., Lunger, M., Nassar, A.M.: Hemodynamic effects of isosorbide dinitrate in patients with rheumatic heart disease and pulmonary hypertension. A preliminary study. Angiology 14, 349–357 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Eckenhoff, J.E., Hafkenschiel, J.H.: Effect of nikethamide on coronary blood flow and cardiac oxygen metabolism. J. Pharmacol. exp. Ther. 91, 362–369 (1947).

    PubMed  CAS  Google Scholar 

  • Eckenhoff, J.E., Hafkenschiel, J.H., Harmel, M.H., Goodale, W.T., Lubin, M., Bing, R.J., Kety, S. S.: Measurement of coronary blood flow by the nitrous oxide method. Amer. J. Physiol. 152, 356–364 (1948).

    PubMed  CAS  Google Scholar 

  • Eckstein, R.W., Newberry, W.B., McEachen, J.A., Smith, G.: Studies of the anti-adrenergic effects of nitroglycerin on the dog heart. Circulation 4, 534–540 (1951).

    PubMed  CAS  Google Scholar 

  • Essex, H.E., Herrick, J.F., Baldes, E.J., Mann, F.C.: Blood flow in the circumflex branch of the left coronary artery of the intact dog. Amer. J. Physiol. 117, 271–279 (1936).

    Google Scholar 

  • Fam, W.M., McGregor, M.: Effect of nitroglycerin and dipyridamole on regional coronary resistance. Circulation Res. 22, 649–659 (1968).

    PubMed  CAS  Google Scholar 

  • Ferrer, M. I., Bradley, S.E., Wheeler, H.O., Enson, Y., Preisig, R., Bricker, P.W., Conroy, R.J., Harvey, R.M.: Some effects of nitroglycerin upon the splanchnic pulmonary, and systemic circulations. Circulation 33, 357–373 (1966).

    PubMed  CAS  Google Scholar 

  • Fortuin, N.J., Kaihara, S., Becker, L.C., Pitt, B.: Regional myocardial blood flow in the dog studied with radioactive microspheres. Cardiovasc. Res. 5, 331–336 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Fremont, R.E.: The actions of organic nitrates on the cardiopulmonary and peripheral circulations. Angiology 12, 391–400 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Gillis, R.A., Melville, ICI.: Coronary flow changes and cardiac adrenergic blockade during nitroglycerin infusions. Europ. J. Pharmacol. 13, 15–22 (1970).

    Article  CAS  Google Scholar 

  • Goldstein, R. E., Stinson, E.B., Epstein, S. E.: Effects of nitroglycerin on coronary collateral function in patients with coronary occlusive disease. Abstracts. Amer. J. Cardiol. 31, 135 (1973).

    Article  Google Scholar 

  • Gorlin, R., Brachfeld, N., MacLeod, C., Bopp, P.: Effect of nitroglycerin on the coronary circulation in patients with coronary artery disease or increased left ventricular work. Circulation 19, 705–718(1959).

    Google Scholar 

  • Gregg, D.E.: The coronary circulation in health and disease. Philadelphia, Pa.: Lea and Febiger 1950.

    Google Scholar 

  • Gregg, D.E., Longino, F.H., Green, P.A., Czerwonka, L.J.: A comparison of coronary flow determination of the nitrous oxide method and by a direct method using the rotameter. Circulation 3, 89–94 (1951).

    PubMed  CAS  Google Scholar 

  • Haddy, F.J.: Physiology and pharmacology of the coronary circulation and myocardium, particularly in relation to coronary artery disease. Amer. J. Med. 47, 274–286 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Hirshleifer, I., Arora, Y.: Nitrites in the treatment of bronchial asthma. Dis. Chest 36, 275–283 (1961).

    Article  Google Scholar 

  • Hollander, W., Madoff, I.M., Chobanian, A.V.: Local myocardial blood flow as indicated by the disappearance of NaI131 from the heart muscle: Studies at rest, during exercise, and following nitrite administration. J. Pharmacol. exp. Ther. 139, 53–59 (1963).

    PubMed  CAS  Google Scholar 

  • Johnson, J.B., Fairley, A., Carter, C.: Effects of sublingual nitroglycerin on pulmonary arterial pressure in patients with left ventricular failure. Ann. intern. Med. 50, 34–42 (1959).

    PubMed  CAS  Google Scholar 

  • Johnson, J.B., Gross, J.F., Hale, E.: Effects of sublingual administration of nitroglycerin on pulmonary-artery pressure in patients with failure of the left ventricule. New Engl. J. Med. 257, 1114–1117(1957).

    Article  PubMed  CAS  Google Scholar 

  • Kaihara, S., VanHeerden, P.D., Migita, T., Wagner, H.N.: Measurement of distribution of cardiac output. J. Appl. Physiol. 25, 696–700 (1968).

    PubMed  CAS  Google Scholar 

  • Khouri, E.M., Gregg, D.E.: Minature electromagnetic flow meter applicable to coronary arteries. J. Appl. Physiol. 18, 224–227 (1963).

    PubMed  CAS  Google Scholar 

  • Kolin, A.: (1960) Circulatory system. Methods; blood flow determination by electromagnetic method. In: Glasser, O. (Ed.): Medical Physics, Vol. III, pp.141–155. Chicago, Ill.: Year Book Publ. Inc. 1960.

    Google Scholar 

  • Kolin, A.: Cardiovascular research. VI. World Congress of Cardiology, London Sept. 1970.

    Google Scholar 

  • Krantz, J.C., Jr., Carr, C.J., Bryant, H.H.: Alkyl nitrites. XIV. The effect of nitrites and nitrates on arterial triphosphatase. J. Pharmacol. exp. Ther. 102, 16–21 (1951).

    PubMed  CAS  Google Scholar 

  • Krantz, J.C., Jr., Carr, C.J., Forman, S.E.: The pharmacology of 2-ethylhexyl nitrite. J. Pharmacol. exp. Ther. 64, 302–306 (1938).

    CAS  Google Scholar 

  • Krantz, J.C., Jr., Carr, C.J., Forman, S.E.: Alkyl nitrites. V. The pharmacology of the high molecular weight alkyl nitrites. Proc. Soc. exp. Biol. (N.Y.) 42, 472–474 (1939 a).

    CAS  Google Scholar 

  • Krantz, J.C., Jr., Carr, C.J., Forman, S.E., Ellis, F.W.: Alkyl nitrates. III. A pharmacologic study of a new series of organic nitrates. J. Pharmacol. exp. Ther. 67, 187–190 (1939 b).

    CAS  Google Scholar 

  • Krantz, J.C., Jr., Lu, G.G., Bell, F. K., Cascorbi, H.F.: Nitrites. XIX. Studies of the mechanism of action of glyceryl trinitrate. Biochem. Pharmacol. 11, 1095–1099 (1962).

    Article  PubMed  Google Scholar 

  • Langendorff, O.: Pflügers Arch. ges. Physiol. 61, 291 (1895). Cited by Charlier, 1971.

    Article  Google Scholar 

  • Leighninger, D.S., Rueger, R., Beck, C.S.: Effect of glyceryl trinitrate (nitroglycerin) on arterial blood supply to ischemic myocardium. Amer. J. Cardiol. 3, 638–646 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Levy, J. V.: Effect of organic nitrates on myocardial oxygen consumption in vitro. Brit. J. Pharmacol. 38, 743–748 (1970).

    CAS  Google Scholar 

  • Mason, D.T., Zelis, R., Amsterdam, E.A.: Actions of the nitrites on the peripheral circulation and myocardial oxygen consumption: significance in the relief of angina pectoris. Dis. Chest 59, 296–305(1971).

    Article  CAS  Google Scholar 

  • Melville, K.I., Gillis, R.A., Sekelj, P.: Coronary flow, blood pressure and heart dose-response changes after nitroglycerin administration. Canad. J. Physiol. Pharmacol. 43, 9–18 (1965).

    Article  CAS  Google Scholar 

  • Morawitz, P., Zahn, K.: Dtsch. Arch. klin. Med. 116, 364–370 (1914). Cited by Krantz et al. (1939 a).

    Google Scholar 

  • Muller, O., Rorvik, K.: Hemodynamic consequences of coronary heart disease. Brit. Heart J. 20, 302–310(1958).

    Article  PubMed  CAS  Google Scholar 

  • Murrell, W.: Nitro-glycerine as a remedy for angina pectoris. Lancet 1879I, 80–81, 113–115, 151–152,225–227.

    Article  Google Scholar 

  • Needleman, P., Hunter, F. E., Jr.: The transformation of glyceryl trinitrate and other nitrates by glutathione-organic nitrate reductase. Mol. Pharmacol. 1, 77–86 (1965).

    PubMed  CAS  Google Scholar 

  • Parker, J.O., Ledwick, J.R., West, R.O., Case, R.B.: Reversible cardiac failure during angina pectoris. Circulation 39, 745–757 (1969).

    PubMed  CAS  Google Scholar 

  • Parker, J.O., West, F.R.O., Giorgi, S.: The effect of nitroglycerin on coronary blood flow and the hemodynamic response to exercise in coronary artery disease. Amer. J. Cardiol. 27, 59–65(1971).

    Article  PubMed  CAS  Google Scholar 

  • Popovich, N.R., Roberts, F.F., Crislip, R.L., Menges, H., Jr.: Ineffectiveness of nitroglycerine as an antiadrenergic agent on the cat heart. Circulation Res. 4, 727–730 (1956).

    PubMed  CAS  Google Scholar 

  • Rath, M., Krantz, J.C., Jr.: Nitrites. VIII. Blood-nitrite content of man and other species. J. Pharmacol. exp. Ther. 76, 27–32 (1942a).

    CAS  Google Scholar 

  • Rath, M., Krantz, J.C., Jr.: Nitrites. IX. A further study of the action of organic nitrates. J. Pharmacol. exp. Ther. 76, 33–38 (1942b).

    CAS  Google Scholar 

  • Ritschel, W.A., Clotten, R.: Entwicklung einer peroralen nitroglycerinprophyllin-retard-form. Arzneimittel-Forsch. 20, 1180–1187 (1970).

    CAS  Google Scholar 

  • Robinson, B.F.: Mode of action of nitroglycerin in angina pectoris. Brit. Heart J. 30, 295–302 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Ross, R.S., Ueda, K., Lichtlen, P.R., Rees, J.R.: Measurement of myocardial blood flow in animals and man by selective injection of radioactive gas into the coronary arteries. Circulation Res. 15, 28–41 (1964).

    PubMed  CAS  Google Scholar 

  • Rosseel, M.T., Bogaert, M.G.: Gas chromatography of the nitrate esters of glycerol, isosorbide and isomannide. J. Chromatog. 65, 364–367 (1972).

    Article  Google Scholar 

  • Roughgarden, J.W., Newman, E.V.: Circulatory changes during the pain of angina pectoris. Amer. J. Med. 41, 935–945 (1966).

    Article  CAS  Google Scholar 

  • Rowe, G.G.: The nitrous oxide method for determining coronary flow in man. Amer. Heart J. 58, 268–281(1959).

    Article  PubMed  CAS  Google Scholar 

  • Rowe, G.G.: Effects of drugs on the coronary circulation of man. Clin. Pharmacol. Ther. 7, 547–557 (1966).

    PubMed  CAS  Google Scholar 

  • Rowe, G.G., Castillo, C.A., Afonso, S., Crumpton, C.W.: Coronary flow measured by the nitrous oxide method. Amer. Heart J. 67, 457–468 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Rowe, G.G., Chelius, C. J., Alfonso, S., Gurtner, H.P., Crumpton, C.W.: Systemic and coronary hemodynamic effects of erythrol tetranitrate. J. clin. Invest. 40, 1217–1222 (1961).

    Article  PubMed  CAS  Google Scholar 

  • Scheline, R.R.: Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol. Rev. 25, 451–523 (1973).

    PubMed  CAS  Google Scholar 

  • Sevelius, G., Johnson, P.C.: Myocardial blood flow determined by surface counting and ratio formula. J. Lab. clin. Med. 54, 669–679 (1959).

    PubMed  CAS  Google Scholar 

  • Stieglitz, E.J., Palmer, A.E.: A colormetric method for the determination of nitrite in blood. J. Pharmacol. exp. Ther. 51, 398–410 (1934).

    CAS  Google Scholar 

  • Stieglitz, E.J., Palmer, A.E.: Nitrite in normal human blood. Arch. intern. Med. 59, 620–624 (1937).

    CAS  Google Scholar 

  • Tawab, S.A., Carr, C.J., Krantz, C.J.: The pharmacology of thiocyanobenzoic acids. J. Pharmacol. exp. Ther. 96, 416–421 (1949).

    PubMed  CAS  Google Scholar 

  • Taylor, S.H.: Reversible left-ventricular failure in angina pectoris. Lancet 31, 902–907 (1970).

    Google Scholar 

  • Truitt, E.B., Jr.: A note on the modification of the Anderson-Craver perfusion apparatus for interchanging perfusion fluids. J. Amer. Pharm. Ass. 44, 382 (1955).

    Article  Google Scholar 

  • Voegtlin, C., Macht, D.I.: The action of nitrites and drugs on the digitalis group on the isolated coronary artery. J. Pharmacol. exp. Ther. 5, 77–86 (1913).

    Google Scholar 

  • Vyden, J.K., Carvalho, M., Boszormenyi, E.: Effect of glyceryl trinitrate (nitroglycerin) on the systemic and coronary circulation of the dog. Amer. J. Cardiol. 25, 53–58 (1970).

    Article  PubMed  CAS  Google Scholar 

  • West, J. W., Guzman, S.V.: Coronary dilation and constriction visualized by selective arteriography. Circulation Res. 7, 527–536 (1959).

    PubMed  CAS  Google Scholar 

  • Whitworth, C.G., Grant, M.M.: Use of nitrate and nitrite vasodilators by glaucomatous patients. Arch. Ophthal. 71, 492–496 (1964).

    PubMed  CAS  Google Scholar 

  • Williams, J.F., Glick, G., Brunwald, W.: Studies on cardiac dimensions in intact anesthesized man. Circulation 32, 767–771 (1965).

    PubMed  CAS  Google Scholar 

  • Winbury, M. M.: Experimental approaches to the development of antianginal drugs. Advanc. Pharmacol. 3, 1–82 (1964).

    Article  CAS  Google Scholar 

  • Winbury, M.M.: Problems in laboratory evaluation of antianginal agents, p.26. Amsterdam: North Holland Pub. Co. 1967.

    Google Scholar 

  • Winbury, M. M.: Redistribution of left ventricular blood flow produced by nitroglycerin. Circulation Res. Suppl. No. 1.1, 140–147 (1971).

    Google Scholar 

  • Winbury, M.M., Gobel, L.P.: Effect of nitrites on nutritional circulation of heart and hindlimb. Amer. J. Physiol. 212, 1062–1066 (1967).

    PubMed  CAS  Google Scholar 

  • Winbury, M.M., Hawe, B.B., Weiss, H.R.: Effect of nitroglycerine and dipyridamole on epicardial and endocardial oxygen tension — further evidence for redistributc of myocardial blood flow. J. Pharmacol. exp. Ther. 176, 184–199 (1971).

    PubMed  CAS  Google Scholar 

  • Zobell, C.E.: Factors influencing the reduction of nitrates and nitrites by bacteria in semisolid media. J. Bacteriol. 24, 273–281 (1932).

    PubMed  CAS  Google Scholar 

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Carr, C.J. (1975). Pharmacological Properties. In: Needleman, P. (eds) Organic Nitrates. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66024-5_4

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