Abstract
Our knowledge of the biochemistry of adrenergic transmission has been greatly aided by the study of the mammalian adrenal medulla. The cells of this tissue are embryologically derived from nervous tissue and contain numerous granules, 0.2–0.5 µm diameter, which may be regarded as hypertrophied noradrenergic synaptic vesicles. These granules are readily isolated by subcellular fractionation and their composition has been studied in some detail [1]. They are known to contain large amounts of adrenaline and some noradrenaline, sequestered within a lipoprotein membrane along with a number of soluble acidic proteins (the main component of which is known as chromogranin A) and appreciable amounts of ATP. The stoichiometry has been worked out in some detail: the molar ratios chromogranin: catecholamine: ATP are about 1:200:50. A detailed description of the structure of the granule core and a knowledge of the physical forces involved is, however, still lacking. Synaptic vesicles isolated from noradrenergic nerves have a generally similar composition and their main core protein is immunochemically identical with chromogranin.
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Whittaker, V.P. (1974). Aspects of the Biochemistry of Cholinergic Transmission in Torpedo and Loligo . In: Jaenicke, L. (eds) Biochemistry of Sensory Functions. Colloquium der Gesellschaft für Biologische Chemie 25.–27. April 1974 in Mosbach/Baden, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66012-2_30
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