Abstract
Bioelectricity and excitability, universal properties of all higher organisms, are already encountered in algae and lower animals. It is, however, most convenient to study bioelectrical phenomena in specialized neuronal tissue evolved for the absorption, processing and transmission of environmental information and for the coordination and regulation of higher organismic function. Such specialized nerve tissue, particulary suited for electrophysiological studies, are the giant axons of certain squids. The coupling of biochemical events and electrical parameters in excitable membranes are readily demonstrable at most neuromuscular junctions or with the isolated electroplax of the electric eel Electrophorus electricus.
Financial support of the Alfred P. Sloan Foundation and the Stiftung Volkswagenwerk is gratefully acknowledged.
Dedicated to the memory Aharon Katzir-Katcialsry (1913–1972).
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References
Agin, D.: Excitability phenomena in membranes. In: Rosen, R. (Ed.): Foundations of mathematical biology, pp. 253–277. New York: Academic Press 1972.
Nachmansohn, D.: Metabolism and function of the nerve cell. In: Harvey Lectures 1953/1954, pp. 57–99. New York: Academic Press 1955.
Nachmansohn, D.: Proteins in bioelectricity. Acetylcholineesterase and -receptor. In: Loewenstein, W. R. (Ed.): Handbook of sensory physiology, Vol. 1, pp. 18–102. Berlin-Heidelberg-New York: Springer 1971.
Neumann, E., Nachmansohn, D., Katchalsky, A.: An attempt at an integral interpretation of nerve excitability. Proc. nat. Acad. Sci. (Wash.) 70, 727–731 (1973).
Hodgkin, A. L.: The conduction of the nervous impulse, Springfield, Ill.: C. C. Thomas 1964.
Tasaki, I.: Nerve excitation. Springfield, Ill.: C. C. Thomas 1968.
Katchalsky, A.: Membrane thermodynamics. In: Quarton, G C, Melnechuk, T., Schmitt, F. O. (Eds.): The neurosciences, pp. 326–343. New York: The Rockefeller University Press 1967.
Prigogine, I.: Thermodynamics of irreversible processes, 3rd ed. Springfield, Ill.: Thomas Publ. 1968.
Tasaki, I., Singer, I.: Membrane macromolecules and nerve excitability: a physico-chemical interpretation of excitation in squid giant axons. Ann N. Y. Acad. Sci. 137, 793–806 (1966).
Cole, K. S.: In: Tobias, C. A. (Ed.): Membranes, ions, and impulses. Berkeley, Calif.: University of California Press 1968.
Hodgkin, A. L., Keynes, R. D.: The potassium permeability of a giant nerve fibre. J. Physiol. (Lond.) 128, 61–88 (1955).
Tasaki, I., Takenada, T.: Ion fluxes and excitability in squid giant axon. In: Hoffman, J.F. (Ed.): The cellular functions of membrane transport. Englewood Cliffs, N. J.: Prentice-Hall Inc. 1964.
Agin, D.: Electroneutrality and electrondiffusion in the squid axon. Proc. nat. Acad. Sci. (Wash.) 57, 1232–1238 (1967).
Segal, J. R.: Surface charge of giant axons of squid and lobster. Biophys. J. 8. 470–489 (1968).
Zelman, A., Sffia, H. H.: The constant field approximation: numerical evaluation for monovalent ions migrating across a homogeneous membrane. J. theor. Biol. 37, 373–383 (1972).
Traurle, H., Eirl, H.: Electrostatic effects on lipid phase transitions: membrane structure and ionic environment. Proc. nat. Acad. Sci. (Wash.) 71, 214–219 (1974).
Tasaki, I., Singer, I., Takenaka, T.: Effects of internal and external ionic environment on excitability of squid giant axon. J. gen. Physiol. 48, 1095–1123 (1965).
Julian, F. J., Goldman, D.E.: The effects of mechanical stimulation on some electrical properties of axons. J. gen. Physiol. 46, 197–313 (1962).
Carnay, L. D., Tasaki, I.: Ion exchange properties and excitability of the squid giant axon. In: Adelman, W.J.,Jr. (Ed.): Biophysics and physiology of excitable membranes, pp. 379–422. New York: Van Nostrand Reinhold Co. 1971.
Katz, B.: Nerve, muscle, and synapse. New York: McGraw-Hill 1966.
Landowne, D.: Movement of sodium ions associated with the nerve impulse. Nature (Lond.) New Biol. 242, 457–459 (1973).
Oster, G. F., Perelson, A. S., Katchalsky, A.: Network thermodynamics: dynamic modelling of biophysical systems. Quart. Rev. Biophys. 6, 1–134 (1973).
Plonsey, R.: Bioelectric phenomena. New York: McGraw-Hill 1969.
Huneeus-Cox, F., Fernandez, H. L., Smith, B. H.: Effects of redox and sulfhydryl reagents on the bioelectric properties of the giant axon of the squid. Biophys. J. 6, 675–689 (1966).
Robertson, J. D.: The ultrastructure of synapses. In: Schmitt, F.O. (Ed.): The neurosciences, Vol. 2, pp. 715–728. New York: The Rockefeller University Press 1970.
Muralt, A.V., Stämpfli, R.: Die photochemische Wirkung von Ultraviolettlicht auf den erregten Ranvierschen Knoten der einzelnen Nervenfaser. Rely. physiol. Acta 11, 182–193 (1953).
Fox, J. M.: Veränderungen der spezifischen Ionenleitfähigkeiten der Nervenmembran durch ultraviolette Strahlung. Dissertation. Homburg-Saarbrücken: 1972.
Evans, M.H.: Tetrodotoxin and saxitoxin in neurobiology. Int. Rev. Neurobiol. 15, 83–166 (1972).
Cole, K. S.: Dielectric properties of living membranes. In: Snell, F. et al. (Eds.): Physical principles of biological membranes, pp. 1–15. New York: Gordon and Breach 1970.
Abbot, B.C., Hill, A. V., Howarth, J. V.: The positive and negative heat production associated with a single impulse. Proc. Roy. Soc. B 148, 149–187 (1958).
Howarth, J. V., Keynes, R.D., Ritchie, J. M.: The origin of the initial heat associated with a single impulse in mammalian non-myelinated nerve fibres. J. Physiol. (Lond.) 194, 745–793 (1968).
Neumann, E.: Molecular hysteresis and its cybernetic significance. Angew. Chem. (int. Edit.) 12, 356–369 (1973).
Guggenheim, E. A.: Thermodynamics. New York: Interscience 1949.
Brzin, M., Dettbarn, W.-D., Rosenberg, PH., Nachmansohn, D.: Cholinesterase activity per unit surface area of conducting membranes. J. Cell Biol. 26, 353–364 (1965).
Gruber, H., Zenker, W.: Acetylcholinesterase: histochemical differentiation between motor and sensory nerve fibres. Brain Res. 51, 207–214 (1973).
Calabro, W.: Sulla regolazione neuro-umorale cardiaca. Riv. biol. 15, 299–320 (1933).
Lisskk, K.: Liberation of acetylcholine and adrenaline by stimulating isolated nerves. Amer. J. Physiol. 127, 263–271 (1939).
Dettbarn, W.-D., Rosenberg, PH.: Effects of ions on the efflux of acetylcholine from peripheral nerve. J. gen. Physiol. 50, 447–460 (1966).
Porter, C. W., Chic, T. H., Wieckowski, J., Barnard, E. A.: Types and locations of cholinergic receptor-like molecules in muscle fibres. Nature (Lond.) New Biol. 241, 3–7 (1973).
Denburg, J. L., Eldefrawi, M. E., O’brien, R. D.: Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics. Proc. nat. Acad. Sci. (Wash.) 69, 177–181 (1972).
Koelle, G. B.: Current concepts of synaptic structure and function. Ann. N. Y. Acad. Sci. 183, 5–20 (1971).
Lewis, P.R., Shute, C. C. D.: The distribution of cholinesterase in cholinergie neurons demonstrated with the electron microscope. J. Cell Sci. 1, 381–390 (1966).
Masland, R. L., Wigton, R. S.: Nerve activity accompanying fasciculation produced by Prostigmine. J. Neurophysiol. 3, 269–275 (1940).
Riker, W.F., Jr., Werner, G., Roberts, J., Kuperman, A.: The pre-synaptic element in neuromuscular transmission. Ann. N.Y. Acad. Sci. 81, 328–344 (1959).
Dettbarn, W.-D.: The acetylcholine system in peripheral nerve. Ann. N.Y. Acad. Sci. 144, 483–503 (1967).
Hoskin, F. C. G., Rosenberg, PH., Brzin, M.: Re-examination of the effect of DFP on electrical and cholinesterase activity of squid giant axon. Proc. nat. Acad. Sci. (Wash.) 55, 1231–1235 (1966).
Nachmansohn, D.: Proteins of excitable membranes. J. gen. Physiol. 54, 187–224 (1969).
Hoskin, F. C. G., Kremzner, L. T., Rosenberg, PH.: Effects of some cholinesterase inhibitors on the squid giant axon. Biochem. Pharmacol. 18, 1727–1737 (1969).
Rosenberg, P., Hoskin, F. C. G.: Demonstration of increased permeability as a factor in the effect of acetylcholine on the electrical activity of venomtreated axons. J. gen. Physiol. 46, 1065–1073 (1963).
Nachmansohn, D.: Actions on axons and the evidence for the role of acetylcholine in axonal conduction. In: Koelle, G.B. (Ed.): Cholinesterases and anticholinesterase agents. Handb. d. exp. Pharmakologie, Erg. XV, pp. 701–740. Berlin-Heidelberg-New York: Springer 1963.
Dettbarn, W.-D.: The effect of curare on conduction in myelinated, isolated nerve fibres of the frog. Nature (Lond.) 186, 891–892 (1960).
Dettbarn, W.-D.: New evidence for the role of acetylcholine in conduction. Biochim biophys. Acta (Amst.) 41, 377–386 (1960).
Bartels, E.: Relationship between acetylcholine and local anesthetics. Biochim. biophys. Acta (Amst) 109, 194–203 (1965).
Seeman, P.: The membrane actions of anesthetics and tranquilizers. Pharmacol. Rev. 24, 583–655 (1972).
Harris, A. J., Dennis, M. J.: Acetylcholine sensitivity and distribution on mouse neuroblastoma cells. Science 167, 1253–1255 (1970).
Nelson, P. G., Peacock, J. H., Amano, T.: Responses of neuroblastoma cells to iontophoretically applied acetylcholine. J. Cell Physiol. 77, 353–362 (1971).
Hamprecht, B.: Cell cultures as model systems for studying the biochemistry of differentiated functions of nerve cells. Hoppe-Seylers Z. physiol. Chem. 355, 109–110 (1974).
Armett, C. J., Ritchie, J.M.: The action of acetylcholine on conduction in mammalian non-myelinated fibres and its prevention by anti-cholinesterase. J. Physiol. (Lond.) 152, 141–158 (1960).
Rrrcxie, J.M.: The action of acetylcholine and related drugs on mammalian non-myelinated nerve fibres. Biochem. Pharmacol. 12 (S), 3 (1963).
Takeuchi, A., Takeuchi, N. Actions of transmitter substances on the neuromuscular junctions of vertebrates and invertebrates. In: Kotani, M. (Ed.): Advan. in Biophys. 3, 45–95. Baltimore: University Park Press 1972.
Nachmansohn, D.: Chemical and molecular basis of nerve activity. New York: Academic Press 1959.
Whittaker, V. P.: The biochemistry of synaptic transmission. Naturwissenschaften 60, 281–289 (1973).
Neher, E., Lux, H. D.: Rapid changes of potassium concentration at the outer surface of exposed single neurons during membrane current flow. J. gen. Physiol. 61, 385–399 (1973).
Spector, I., Kimm, Y, Nelson, P.G.: Tetrodotoxin and cobalt blockage of Neuroblastoma action potentials. Nature (Lond.) New Biol. 246, 124–126 (1973).
Adam, G.: Theory of nerve excitation as a cooperative cation exchange in a two-dimensional lattice. In: Snell, F., et al. (Eds.): Physical principles of biological membranes, pp. 35–64. New York: Gordon and Breach 1970.
Katchalsky, A., Spangler, R.: Dynamics of membrane processes. Quart. Rev. Biophys. 1, 127–175 (1968).
Blumenthal, R., Changeux, J.-P., Lefèvre, R.: Membrane excitability and dissipative instabilities. J. Membrane Biol. 2, 351–374 (1970).
Rawlings, P. K., Neumann, E.: In preparation.
Eigen, M.: Dynamic aspects of information transfer and reaction control in biomolecular systems. In: Quarton, G. C., Melnecruk, T., Schmitt, F. O. (Eds.): The neurosciences, pp. 130–142. New York: The Rockefeller University Press 1967.
Neumann, E., Katchalsky, A.: Long-lived conformation changes induced by electric impulses in biopolymers. Proc. nat. Acad. Sci. (Wash.) 69, 993–997 (1972).
Revzin, A., Neumann, E.: Conformational changes in rRNA induced by electric impulses. Biophys. Chem. 2, 144–150 (1974).
Neumann, E., Rosenheck, K.: Permeability changes induced by electric impulses in vesicular membranes. J. Membrane Biol. 10, 279–290 (1972).
Eigen, M., Demaeyer, L.: Relaxation methods. In: Friess, S. L., Lewis, E. S., Weissberger, A. (Eds.): Technique of organic chemistry, Vol. 8, p. 895. New York: Interscience Publ. Inc. 1963.
Neumann, E., Nachmansohn, D.: In Manson, L. (Ed.): Biomembranes, Vol. 7. London. New York: Academic Press 1974.
Chang, Rai Won: Purification and characterization of acetylcholine receptor-I from electrophorus electricus. Proc. nat. Acad. Sci. (Wash.) 71, 2113–2117 (1974).
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Neumann, E. (1974). Towards a Molecular Model of Nerve Excitability. In: Jaenicke, L. (eds) Biochemistry of Sensory Functions. Colloquium der Gesellschaft für Biologische Chemie 25.–27. April 1974 in Mosbach/Baden, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66012-2_29
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