Immunogenetic Studies on Cell Surface Components of the Mammalian Nervous System

  • Melitta Schachner
Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 25.–27. April 1974 in Mosbach/Baden book series (MOSBACH, volume 25)

Abstract

Interest in the composition of the outer membrane surface of nerve cells stems from its possible significance for morphogenesis and differentiation. The ontogenetic specification of tissue organization has been elaborated to a very elegant extreme in the nervous system, since most of its functional properties derive from the particular ways in which nerve cell contacts are organized. In terms of cytoarchitecture, the outstanding feature of the nervous system is that each neuron receives information from many other neurons and in turn transmits to many target cells, the extent of this convergence and divergence varying among regions and among classes of cells. Evidence from morphological and biochemical studies suggests that this functional specialization involves the development of topographically distinct sites on the surface membrane of a given nerve cell [1–3]. It is commonly assumed that these mosaic surface properties, which seem to mediate the specificity of surface contacts, become established in the mammal during embryonic and early postnatal development [3]. Direct molecular data on these organizational features at any stage of development, under any normal or pathological conditions are, however, very scarce.

Keywords

Leukemia Sedimentation Neuroblastoma Blastoma Methylcholanthrene 

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References

  1. 1.
    Jacobson, M.: Developmental neurobiology, p. 465. New York: Holt, Rinehart, and Winston (1970).Google Scholar
  2. 2.
    Gaze, R. M.: The formation of nerve connections, p. 299. New York: Academic Press (1970).Google Scholar
  3. 3.
    Sidman, R. L.: Contact interaction among developing mammalian brain cells. In: Moscona, A. (Ed.): Symposium on cell surface development. Proceedings of the Seventh International Congress of Developmental Biology. New York: John Wiley and Sons, Inc., 1974 (in press).Google Scholar
  4. 4.
    Boyse, E. A., Old, L. J.: Some aspects of normal and abnormal cell surface genetics. Ann. Rev. Gent. 3, 269–290 (1969).CrossRefGoogle Scholar
  5. 5.
    Hamberoer, A., Hyden, H.: Inverse enzymatic changes in neurons and glia during increased function and hypoxia. J. Cell Biol. 16, 521–525 (1963).CrossRefGoogle Scholar
  6. 6.
    Rose, S. P.R.: Preparation of enriched fractions from cerebral cortex containing isolated metabolically active neuronal and glial cells. Biochem. J. 102, 33–43 (1967).PubMedGoogle Scholar
  7. 7.
    Norton, W. T., Poduslo, S. E.: Neuronal soma and whole neuroglia of rat brain: A new isolation technique. Science 167, 1144–1146 (1970).PubMedCrossRefGoogle Scholar
  8. 8.
    Barkley, D. S., Rakic, L. L., Chaffee, J. K., Wong, D. L.: Cell separation by velocity sedimentation of postnatal mouse cerebellum. J. Cell Physiol. 28, 271–280 (1973).CrossRefGoogle Scholar
  9. 9.
    Schachner, M., Hämmerling, U.: The postnatal development of antigens on mouse brain cell surfaces. Brain Res. 73, 362–371 (1974).PubMedCrossRefGoogle Scholar
  10. 10.
    Schachner, M.: NS-1 (nervous system antigen-1), a glial-cell specific antigenic component of the surface membrane. Proc. nat. Acad. Sci., USA. 71, 1795–1799 (1974).CrossRefGoogle Scholar
  11. 11.
    Sidman, R. L., Green, M. C., Appel, S. H.: Catalog of the neurological mutants of the Mouse, pp. 1–82. Cambridge, Mass.: Harvard Univ. (1965).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • Melitta Schachner
    • 1
  1. 1.Department of Neuropathology, Harvard Medical School and Department of NeuroscienceChildren’s Hospital Medical CenterBostonUSA

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