Quantitative Interrelationships between Plasma Constituents and Normal and Atherosclerotic Human Intimal Tissue
Most of the cholesterol which accumulates in arterial intima appears to be derived from plasma (reviewed by Dayton and Hashimoto, 1970; Portman, 1970). The cholesterol esters which accumulate in extracellular locations also appear to be derived directly from plasma, but those which accumulate inside fat-filled cells are probably formed by esterification in situ (Smith et al., 1967; Smith and Slater, 1972a). Using the technique of immunofluorescent microscopy numerous investigators have demonstrated LD-lipoprotein in normal intima (with the exception of the youngest age groups, Kao and Wissler, 1965) and in lesions of all types (reviewed by Smith and Slater, 1970). There is less agreement on the presence of other plasma constituents, but albumin, HDL and fibrinogen or fibrin have also been demonstrated (Haust et al., 1965; Wyllie et al., 1964; Haust, 1968). It seems probable that all plasma proteins are present in the intima with the possible exception of intact VLDL.
KeywordsSerum Cholesterol Level Early Lesion Fatty Streak Patient Plasma Fibrous Plaque
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