Interrelationship of Plasma Free Fatty Acids and Blood Beta-Hydroxybutyrate Concentration in Coronary Artery Disease
The incidence of coronary artery disease (CAD) has increased during the latter half of this century and accounts for 33 per cent of male deaths between the ages of 45–54 years and 25 per cent of male deaths between the ages of 35–44 years (Oliver, 1969). The aetiology is multifactorial and hyperlipidaemia has been found to be an important factor. This includes elevations of both cholesterol and triglyceride concentrations in the blood. In addition, increased concentrations of insulin have been found in CAD (Peters and Hales, 1965; Nikkila et al., 1965). It is possible that insulin plays a role in atherogenesis by increasing the production of triglyceride. The purpose of this study was to find out whether insulin might regulate the metabolism of free fatty acids (FFA) to triglycerides in liver. The pathway of metabolism of FFA is shown in Fig. 1. If insulin modifies the metabolism of FFA by liver, it may affect the proportion of FFA converted to triglycerides as opposed to ketone bodies.
KeywordsCholesterol Ketone Triglyceride Glyceride Acetoacetate
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