Workshop: Types and Genetics of Hyperlipoproteinemias
The underlying concept of the National Heart and Lung Institute typing system as developed by Fredrickson, Levy and Lees (1967), and as previously emphasized by Gofman et al. (1954), is by now well known; namely, the need to translate hyper-lipidemia into hyperlipoproteinemia, since it is as lipoproteins rather than as individual lipids that the major plasma lipids circulate and since different patterns of hyperlipoproteinemia are associated with characteristic features. Of the utility of the phenotyping system, there can be no doubt. Most important, it introduced a standard nomenclature where one hardly existed previously. Subsequent to the system’s introduction there has been a considerable expansion of work and interest in the field of hyperlipidemia and hyperlipoproteinemia. Further, it has led to a more precise definition of several disorders in terms of their clinical, biochemical, pathological and genetic features, and therapeutic requirements.
KeywordsCholesterol Migraine Electrophoresis Anemia Stein
Unable to display preview. Download preview PDF.