Differences between Human and Animal Atherosclerosis
Atherosclerosis, perhaps more than any other widespread and life-threatening pathological process of modern times, needs to be studied using experimental models. It is very difficult to study the pathogenesis of this disease process adequately in man because it has a complex, multi-faceted set of initiating and augmenting factors; it comes on slowly over a long life span; and it produces essentially no clinical effects until it is far advanced. Furthermore, it is very difficult, short of relatively risky invasive techniques, to document the severity of atherosclerosis in any part of the arterial tree until it produces clinical effects (McGill et al., 1963).
KeywordsThoracic Aorta Small Artery Fatty Streak Atherogenic Diet Serum Sickness
Unable to display preview. Download preview PDF.