Behavior of Fibrinogen and Fibrinolysis in Type II and Type IV Hyperlipemic Subjects and in Patients with Coronary Heart Disease
Since the hypothesis of Duguid (1946) that atheroma may be derived from “mural fibrin thrombi”, the attention of many investigators has been focused on the possible significance of changes in fibrinolytic activity and plasma fibrinogen in the pathogenesis of CHD (coronary heart disease). The interest in the possible relationship between elevated serum lipid levels, increase of fibrinogen and/or defective fibrinolysis, and CHD, encouraged us to investigate the behavior of fibrinogen and fibrinolytic activity in hyperlipemic (type II A-B and type IV) subjects without CHD and in hyperlipemic and normolipemic patients with CHD, compared with subjects free from CHD and lipid abnormalities (controls).
KeywordsCoronary Heart Disease Ischemic Heart Disease Fibrinolytic Activity Lipid Abnormality Plasma Fibrinogen
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