Increased Collagen Synthesis in Early Rabbit Atherosclerosis and its Inhibition by CIS-Hydroxyproline
The examination of histological section prepared from human coronary arteries, taken post-mortem from patients who have died from coronary heart disease often reveals that the occlusive or stenosing aspect of atherosclerotic lesions is not lipid but dense fibrous connective tissue. This facet of the disease is not always recognized in experimental animal lesions but has been well described in human atherosclerosis (Constantinides, 1965; Friedman, 1964; Smith, 1965; Levene and Poole, 1962).
KeywordsCollagen Synthesis Fatty Streak Human Coronary Artery Rabbit Aorta Tendon Cell
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