Endothelial Permeability: Focal and Regional Patterns of 131I-Albumin and 131I-Fibrinogen Uptake and Transmural Distribution in the Pig Aorta
The focal nature of atherosclerotic lesions has been a consistent observation in both naturally-occurring and experimental atherosclerosis although the focal determinants of focal lesion development remain uncertain. One point of view considers that areas of arterial lesion development represent areas of increased enothelial permeability (or decreased clearance) to plasma constituents. Indeed, numerous workers (Gerö et al., 1961; Watts, 1963; Haust et al., 1964; Kao and Wissler, 1965; Smith et al., 1973) have by various means identified a wide range of plasma constituents associated with atherosclerotic lesions.
KeywordsAortic Arch Arterial Wall Evans Blue Atherogenic Diet Plasma Constituent
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