Workshop: Management of Hyperlipoproteinemias with Non-Absorbable Drugs
The workshop in the management of atherosclerosis was concerned with non-absorb-able drugs. These agents act within the intestinal lumen interfering with cholesterol and bile acid absorption. The resulting enhanced elimination of cholesterol leads to reduction of plasma cholesterol, a phenomenon generally believed to inhibit or at least retard progression of atherosclerotic lesions in coronary and other arteries of patients with hypercholesterolemia. The major ultimate aim of the therapy with non-absorbable hypocholesterolaemic drugs is to prevent clinical manifestations of atheromatosis such as sudden death and myocardial infarctions. No prospective controlled studies have been performed so far demonstrating that this goal can be achieved with hypocholesterolaemic drug therapy.
KeywordsBile Acid Plasma Cholesterol Plant Sterol Bile Acid Sequestrant Bile Acid Excretion
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