Zusammenfassung
An der isolierten perfundierten Rattenleber wurden die Folgen einer Hemmung der mitochondrialen Atmungskette durch Ēthrane und Halothan gezeigt: der Sauerstoffverbrauch war vermindert; die Redoxindikatoren Lactat/Pyruvat und ʲ-Hydroxybutyrat/A cetoacetat zeigten einen Anstau von reduzierten Äquivalenten; die eingeschränkte Bereitstellung von energiereichem Phosphat führte zu einer Hemmung der Gluconeogenese aus Alanin, Lactat und Dihydroxyaceton. Bei gleicher Konzentration der in der wässrigen Phase gelösten Narkosegase waren die Wirkungen von Ēthrane und Halothan qualitativ und quantitativ gleich.
Summary
The results of inhibition of the mitochondrial respiratory chain by Ēthrane and Halothane were studied in isolated perfused rat liver. Oxygen uptake was diminished; the substrate pairs lactate/pyruvate and ß-hydroxybutyrate/acetoacetate indicated a more reduced state of the cellular NADH-systems, due to a diminished supply of energy-rich phosphates; and gluconeogenesis from lactate, alanine and dihydroxyacetone was inhibited. The effects of Ēthrane and Halothane on the basis of concentrations in the aqueous phase were identical.
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Götz, E., Scholz, R. (1974). Stoffwechselwirkungen von Ēthrane und Halothan in der isolierten perfundierten Rattenleber. In: Lawin, P., Beer, R., Wiethoff, E. (eds) Ēthrane. Anaesthesiology and Resuscitation / Anaesthesiologie und Wiederbelebung / Anesthésiologie et Réanimation, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65931-7_5
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DOI: https://doi.org/10.1007/978-3-642-65931-7_5
Publisher Name: Springer, Berlin, Heidelberg
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