Vagotomy pp 72-74 | Cite as

Effect of Pyloroplasty on Gastric Secretion after SPV and SV in Dogs

  • F. Holle
  • F. Okukubo


The safest way to eliminate the cephalic phase alone is to carry out complete SPV (cf. p. 69). This procedure also allows examination of the gastric phase alone. The controlling impulse of the gastric phase is gastrin. Feeding is its most physiological stimulus. Feeding of a selectively proximally denervated stomach is a method for determining gastrin release and obtaining information on the gastric phase. The amount of gastrin released is the only measure of the response of the gastrin cells to the gastrin-regulating factors that still influence the antrum after SPV. These are:
  1. 1.

    distention of the antrum

  2. 2.

    pH milieu on the antral mucosa

  3. 3.

    vagal-antral gastrin release

  4. 4.

    number and expansion of gastrin-cells.



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  1. Holle, F.: Discussion at the topic of combination of an SpV with pyloroplasty. 4th World Congress of Gastroenterology, Copenhagen, 17.7.1970Google Scholar
  2. Klempa, J., Holle, F., Wolff, A. v., Händle, H., Bruckner, W., Welsch, K. H.: Tierexperimentelle Untersuchungen zur Brauchbarkeit einer selektiven proximalen Vagotomie. I. Mitteilung: Die Bedeutung der Pyloroplastik in Kombination mit einer SpV. Langb. Arch. Chir., Kongreβbericht(1970)Google Scholar
  3. Klempa, J., Holle, F., Bruckner, W., Welsch, K. H., Handle, H., v. Wolff, A.: The effect of selective proximal Vagotomy and Pyloroplasty on Gastric Secretion and motility in the dog. Arch. Surg. 103, (1971)Google Scholar
  4. Okukubo, F., Holle, F.,: The meaning of pyloroplasty after selective proximal Vagotomy controlled by S-Gastrin estimation. Bull. Soc. Internat. Chir., Tome XXXII. n. 4, 5, 6. July-Dee.1973.Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • F. Holle
  • F. Okukubo

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