Effects of Diphenylhydantoin on Local Cerebral Blood Flow

  • M. DesRosiers
  • G. D. Grave
  • H. J. Kupferberg
  • C. Kennedy


The action of diphenylhydantoin (DPH) on neural tissues has been extensively studied, but little is known of its effect on the cerebral circulation. Some years ago a limited number of observations in man suggested the possibility that anticonvulsant doses administered orally resulted in mild increments in overall cerebral blood flow (6). Since that time some experimental evidence has accrued to indicate that DPH might lower cerebral metabolic activity (1, 5, 11). Such an action in vivo could be expected to cause a reduction in cerebral blood flow assuming the integrity of the regulatory mechanism by which blood flow is adjusted to metabolic demand. The following study was undertaken in an effort to resolve these conflicting considerations.


Cerebral Blood Flow Medial Geniculate Body Local Cerebral Blood Flow Arterial Blood Pressure Measure Anticonvulsant Dose 
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Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • M. DesRosiers
  • G. D. Grave
  • H. J. Kupferberg
  • C. Kennedy

There are no affiliations available

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