Effects of Diphenylhydantoin on Local Cerebral Blood Flow
The action of diphenylhydantoin (DPH) on neural tissues has been extensively studied, but little is known of its effect on the cerebral circulation. Some years ago a limited number of observations in man suggested the possibility that anticonvulsant doses administered orally resulted in mild increments in overall cerebral blood flow (6). Since that time some experimental evidence has accrued to indicate that DPH might lower cerebral metabolic activity (1, 5, 11). Such an action in vivo could be expected to cause a reduction in cerebral blood flow assuming the integrity of the regulatory mechanism by which blood flow is adjusted to metabolic demand. The following study was undertaken in an effort to resolve these conflicting considerations.
KeywordsCerebral Blood Flow Medial Geniculate Body Local Cerebral Blood Flow Arterial Blood Pressure Measure Anticonvulsant Dose
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- 1.Broddle, W., and Nelson, S. R.: “The effect of diphenylhydantoin on energy reserve levels in brain.” Federation Proc. 27:751 (1968).Google Scholar
- 3.Freygang, W. H., and Sokoloff, L.: “Quantitative measurement of regional circulation in the central nervous system by use of radioactive inert gas.” Adv. Biolog. Med. Phys. 6:263–279 (1959).Google Scholar
- 5.Hutchins, D. A., and Rogers, K. J.: “Physiological and drug-induced changes in the glycogen content of mouse brain.” Brit. J. Pharm. 39:9–25 (1970).Google Scholar
- 6.Kennedy, C., Anderson, W., and Sokoloff, L.: “Cerebral blood flow in epileptic children during the interseizure period.” Neurology, 8 Supplement 1:100–105 (1958).Google Scholar
- 9.Vanasin, B., Bass, D. D., Mendeloff, A. I., and Schuster, M. M.: “Effect and site of action of diphenylhydantoin (DPH) on gastrointestinal smooth muscle.” Clin. Res. 18:391 (1970).Google Scholar
- 11.Vernadakis, A., and Woodbury, D. M.: “Effects of diphenylhydantoin and adrenocortical steroids on free glutamic acid, glutamine and gamma-aminobutyric acid concentrations of rat cerebral cortex.” International Conference on Inhibition of the Nervous System and Gamma-Aminobutyric Acid, California. Oxford: Pergamon Press (1959), pp. 242–248.Google Scholar