Abstract
The present study describes a relatively simple technique for the resolution of regional flow in the cat using 15 ± 5 μ microspheres and the reference sample method of flow quantification. If one does not wish to measure cardiac output (5, 9, 10, 11) nor be concerned with residual isotope in syringe and tubing, it is possible to determine flow by employing an independent flow method to a reference organ (FK) and the radioactivity (CK) in that organ. Since the microsphere method implies that the ratio of flow and radioactivity will be the same in all organs, one can determine brain organ flow (FB) by measuring the activity of the entire brain (CB) and solving the equation
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alm, A., and Bill, A.: “The oxygen supply to the retina. II. Effects of high intraocular pressure and increased arterial carbon dioxide tension on uveal and retinal blood flow in cats.” Acta Physiol. Scand. 84:306–319 (1972).
Buckberg, G. D., Luck, J. C., Payne, D. B., Hoffman, J. I. E., Archie, J. P., and Fixier, D. E.: “Some sources of error in measuring regional blood flow with radioactive microspheres.” J. Appl. Physiol. 31:598–604 (1971).
Granholm, L., Kaasik, A. E., Millson, L., and Siesjö, B. K.: “The lactate/pyruvate ratio of cerebrospinal fluid of rats and cats related to the lactate/ pyruvate, ATP/ADP, and the phosphocreatine/creatine ratios of brain tissue.” Acta Physiol. Scand. 74:398–409 (1968).
Hohorst, H.-J.: “Methods of enzymatic analysis.” In: Verlag Chemie, H. Bergmer, ed. New York: Academic Press (1963).
Kaihara, S., Van Heerden, P. D., Migita, T., and Wagner, H. N., Jr.: “Measurement of the distribution of cardiac output.” J. Appl. Physiol. 25:696–700 (1968).
Kennady, J. C., and Taplin, G. V.: “Safety of measuring regional cerebrocortical blood flow with radioalbumin monoaggregates.” J. Nucl. Med. 7:345 (1966).
Landau, W. M., Freygang, W. H., Jr., Roland, L. P., and Kety, S. S.: “The local circulation of the living brain; values in the unanesthetized and anesthetized cat.” Trans. Amer. Neurol. Assoc. 81:125–129 (1955).
Prosenz, P.: “Investigations on the filter capacity of the dog’s brain.” Arch. Neurol. 26:479–488 (1972).
Roth, J. A., Greenfield, A. J., Kaihara, S., and Wagner, H. N., Jr.: “Total and regional cerebral blood flow in unanesthetized dogs.” Am. J. Physiol. 219:96–101 (1970).
Rudolph, A. M., and Heymann, M. A.: “The circulation of the fetus in utero: methods for studying distribution of blood flow, cardiac output and organ blood flow.” Circ. Res. 21:163–184 (1967).
Saperstein, L. A.: “Regional blood flow by fractional distribution of indicators.” Am. J. Physiol. 193:161–168 (1958).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Shulman, K., Furman, M., Rosende, R. (1975). Regional Cerebral Blood Flow. Evaluation of the Microsphere Technique. In: Langfitt, T.W., McHenry, L.C., Reivich, M., Wollman, H. (eds) Cerebral Circulation and Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65814-3_40
Download citation
DOI: https://doi.org/10.1007/978-3-642-65814-3_40
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-65816-7
Online ISBN: 978-3-642-65814-3
eBook Packages: Springer Book Archive