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Acute Arterial Hypertension and the Blood-Brain Barrier: An Experimental Study in Dogs

  • B. Ekström-Jodal
  • E. Häggendal
  • B. Johansson
  • L.-E. Linder
  • N. J. Nilsson

Abstract

A sudden large arterial blood pressure increase induced by Aramine has been found to cause blood-brain barrier (BBB) damage, while a stepwise rise in pressure to the same total increment leaves the BBB intact. The interpretation was that during the slow rise the autoregulatory mechanism was given time enough to prevent the pressure increase from being transmitted to the small vessels to the same extent as’with the sudden blood pressure rise (3). The pressure-flow relation in nonpharmacologically induced arterial hypertension shows autoregulation up to a certain limit, which at low or ordinary flow levels is usually found at a mean arterial blood pressure around 200 mm Hg. The higher the normotensive flow level was, the lower was the upper limit for autoregulation. Above the autoregulatory pressure limit a flow increase occurred (1).

Keywords

Arterial Blood Pressure Flow Level Elimination Curve Autoregulatory Pressure Autoregulatory Range 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ekström-Jodal, B., Häggendal, E., Linder, L.-E., and Nilsson, N. J.: “Cerebral blood flow auto-regulation at high arterial pressures and different levels of carbon dioxide tension in dogs.” European Neurol. 6:6–10 (1971/72).CrossRefGoogle Scholar
  2. 2.
    Ekström-Jodal, B., Häggendal, E., and Nilsson, N. J.: “The cerebral venous oxygen saturation during rapid changes in the arterial blood pressure. An oximetric study in dogs.” Acta Physiol. Scand. Suppl. 350:43–50 (1970).Google Scholar
  3. 3.
    Häggendal, E., and Johansson, B.: “Pathophysiological aspects of the blood brain barrier change in acute arterial hypertension.” European Neurol. 6:24–28 (1971/72).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • B. Ekström-Jodal
  • E. Häggendal
  • B. Johansson
  • L.-E. Linder
  • N. J. Nilsson

There are no affiliations available

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