Abstract
Since the discovery of GABA as a distinctive constituent of vertebrate brains, extensive studies concerning its role in the central nervous system have been undertaken. Of relevance to cerebral blood flow and strokes is the report of Lovell and his colleagues (4) that rises in brain GABA were sensitive to hypoxic conditions. Wood and Watson (9) showed similar increases of GABA content in rat and guinea pig brains when these animals were exposed to 5% oxygen and 95% nitrogen. In addition, under such hypoxic conditions, as well as ischemia, it is known that cerebral high energy phosphate levels are quickly reduced. For example, Lowry and his associates (5) reported that with complete ischemia created by decapitation, creatine, phosphate, and ATP decrease rapidly in brain tissue.
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References
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© 1975 Springer-Verlag New York Inc.
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Lee, L.W., Yatsu, F.M. (1975). The Effect of γ-Aminobutyric Acid (GABA) on Brain ATP Synthesis during Ischemia. In: Langfitt, T.W., McHenry, L.C., Reivich, M., Wollman, H. (eds) Cerebral Circulation and Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65814-3_130
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DOI: https://doi.org/10.1007/978-3-642-65814-3_130
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