Regional Differences in β-Adrenergic Effects on Local Cerebral Blood Flow and Adrenergic Innervation

  • J. Seylaz
  • P. Aubineau
  • L. Edvinsson
  • H. Mamo
  • K. C. Nielsen
  • C. Owman
  • R. Sercombe


Although it is now well documented (6, 8) that pial as well as intracerebral vessels are amply supplied with sympathetic adrenergic nerves which, as shown for pial arteries, fulfill ultra-structural (5) as well as pharmacologic (7) criteria for a true vasomotor innervation, the role of these fibers in the regulation of cerebral blood flow (CBF) remains a subject of considerable controversy. One reason is the inability of some investigators to obtain measurable changes in CBF after administration of sympathomimetic compounds; when an alteration is observed, the compound is assumed to have acted indirectly through modifications of brain metabolism.


Cerebral Blood Flow Local Blood Flow Adrenergic Nerve Local Cerebral Blood Flow Adrenergic Innervation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Aubineau, P. F., Seylaz, J., Sercombe, R., and Mamo, H.: “Chronic implantation of a wide bore catheter in the rabbit.” Manuscript in preparation.Google Scholar
  2. 2.
    Björklund, A., Falck, B., and Owman, Ch.: “Fluorescence microscopic and microspectrofluoro-metric techniques for the cellular localization and characterization of biogenic amines.” In Methods of Investigative and Diagnostic Endocrinology, Vol. 1, The Thyroid and Biogenic Amines, S. A. Berson, J. E. Rall, and I. J. Kopin, eds. Amsterdam: North-Holland (1972), pp. 318–368.Google Scholar
  3. 3.
    Hökfelt, T., and Ljungdahl, A.: “Modification of the Falck-Hillarp formaldehyde fluorescence method using the Vibratome®. Simple, rapid, and sensitive localization of catecholamines in sections of unfixed or formalin fixed brain tissue.” Histochemie 29:325 (1972).PubMedGoogle Scholar
  4. 4.
    Macdonnell, L., Xanalatos, C., Hall, S., and James, I. M.: “Factors affecting the response of cerebral metabolism and blood flow to a noradrenaline infusion in the dog.” Europ. Neurol. 6:208 (1971–1972).Google Scholar
  5. 5.
    Nelson, E., and Renneis, M.: “Innervation of intracranial arteries.” Brain 93:475 (1970).PubMedCrossRefGoogle Scholar
  6. 6.
    Nielsen, K. C., and Owman, Ch.: “Adrenergic innervation of pial arteries related to the circle of Willis in the cat.” Brain Res. 6:33 (1971).CrossRefGoogle Scholar
  7. 7.
    Nielsen, K. C., Owman, Ch., and Sporrong, B.: “Sympathetic nervous control of pial arteries. Tyramine-induced contraction of the isolated middle cerebral artery of the cat.” In Brain and Blood Flow, R. W. Ross Russell, ed. London: Pitman Medical and Scientific (1971), pp. 244–247.Google Scholar
  8. 8.
    Purves, M. J.: “The Physiology of the Cerebral Circulation”. Cambridge: Cambridge Univ. Press (1972), pp. 1–420.Google Scholar
  9. 9.
    Schroeder, J. S., Robison, S. C., Miller, H. A., and Harrison, D. C.: “Effects of respiratory acidosis on circulatory response to isoproterenol.” Amer. J. Physiol 218:448 (1970).PubMedGoogle Scholar
  10. 10.
    Seylaz, J.: “Biophysique de la mesure rapide de l’irrigation sanguine locale.” Helv. Physiol. Pharmacol. Acta 26:1 (1968).PubMedGoogle Scholar
  11. 11.
    Seylaz, J., Aubineau, P. F., Correze, J. L., and Mamo, H.: “Continuous measurement of local cerebral blood flow, PaO2, PaCO2, and blood pressure in the nonanesthetized animal.” Pflügers’ Arch., 340:175–180 (1973).CrossRefGoogle Scholar
  12. 12.
    Seylaz, J., Correze, J. L., Pinard, E., and Mamo, H.: “Technological advances in continuous measurement of blood gas partial pressures by means of mass-spectrography.” manuscript in preparation.Google Scholar
  13. 13.
    Weil-Malherbe, H., Whitby, L. G., and Axelrod, J.: “The blood brain barrier for catecholamines in different regions of the brain.” In Regional Neurochemistry, S. S. Kety and J. Elkes, eds. Oxford: Pergamon Press (1961), pp. 284–292.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • J. Seylaz
  • P. Aubineau
  • L. Edvinsson
  • H. Mamo
  • K. C. Nielsen
  • C. Owman
  • R. Sercombe

There are no affiliations available

Personalised recommendations