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Mechanism of Action of Glucocorticoids

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Antineoplastic and Immunosuppressive Agents

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Abstract

Although recent advances in our knowledge of hormone action have been impressive, there is at present no clear understanding of how any hormone acts at the molecular level. This is one of the major unsolved problems in biology today. It seems evident that one or more hormones are involved in the growth and metabolism of most normal tissues. The fact that certain tumors are hormone dependent or responsive also indicates that hormones may play an important role in the etiology and treatment of cancer. There is little doubt that knowledge concerning hormone action is likely to yield new insight and provide different approaches to the treatment of various diseases, including cancer.

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Authors
  1. Fred Rosen
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  2. Richard J. Milholland
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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Rosen, F., Milholland, R.J. (1975). Mechanism of Action of Glucocorticoids. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_7

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