The vinca alkaloids and the colchicine derivatives, although of widely disparate chemical structure, may be considered to constitute a single class of agents in view of the many similarities in their biochemical and biological actions, most notably in their ability to produce metaphase arrest. This resemblance extends to certain other unrelated compounds, including griseofulvin and podophyllotoxin.


Vinca Alkaloid Ehrlich Ascites Carcinoma Cell Inappropriate Antidiuretic Hormone Secretion Antimitotic Agent Microtubule Protein 
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© springer-Verlag Berlin-Heidelberg 1975

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  • William A. Creasey

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