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Vinca Alkaloids and Colchicine

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Antineoplastic and Immunosuppressive Agents

Abstract

The vinca alkaloids and the colchicine derivatives, although of widely disparate chemical structure, may be considered to constitute a single class of agents in view of the many similarities in their biochemical and biological actions, most notably in their ability to produce metaphase arrest. This resemblance extends to certain other unrelated compounds, including griseofulvin and podophyllotoxin.

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  1. William A. Creasey
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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Creasey, W.A. (1975). Vinca Alkaloids and Colchicine. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_38

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