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Antineoplastic and Immunosuppressive Agents pp 554–570Cite as

Cytotoxic Inhibitors of Protein Synthesis

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Abstract

Many antineoplastic agents exert profound inhibitory effects on protein synthesis. With few exceptions, such drugs are too toxic to be used for therapeutic purposes, but many have been employed as experimental tools in cell biology. Several reviews and symposia have been devoted to this topic (Goldberg, 1965; Gottlieb and Shaw, 1967; Bucher and Sies, 1969; Pestka, 1971; Munoz et al., 1972; Grollman and Huang, 1973), and this chapter will attempt to summarize current knowledge of the biochemical pharmacology of these drugs.

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Authors
  1. Arthur P. Grollman
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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Grollman, A.P. (1975). Cytotoxic Inhibitors of Protein Synthesis. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_28

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