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Hormones and Transcriptional Activity of Chromatin

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Invertebrate Endocrinology and Hormonal Heterophylly

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Abstract

Ever since their discovery, hormones have been known to increase the rates of numerous metabolic processes in vivo. More recent research shows that the administration of hormones frequently induces or increases, in their target tissues, the activity of specific enzymes and initiates biosynthesis of new proteins as well as new RNA species. Many hormones, especially steroids, change the transcriptional activity of chromatin not only quantitatively, as demonstrated by its increased templating efficiency for RNA synthesis both in vivo and in vitro, but also modify the selectivity of genetic restriction as witnessed by compositional changes of the RNA biosynthesized under the influence of hormone. It can be assumed, therefore, that the interaction between certain hormones and their target tissues results in reprogramming of the DNA restriction in chromatin of the affected cells. The aim of this presentation is to discuss how such a genetic reprogramming can be effected at the molecular level.

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Authors
  1. L. S. Hnilica
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  2. Y. H. Tsai
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  3. T. C. Spelsberg
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Editors and Affiliations

  1. The University of Texas, Houston, Texas, 77025, USA

    Walter J. Burdette Ph.D., M.D. (Professor of Surgery) (Professor of Surgery)

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Hnilica, L.S., Tsai, Y.H., Spelsberg, T.C. (1974). Hormones and Transcriptional Activity of Chromatin. In: Burdette, W.J. (eds) Invertebrate Endocrinology and Hormonal Heterophylly. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65769-6_20

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  • DOI: https://doi.org/10.1007/978-3-642-65769-6_20

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