The Influence of Ventilatory Changes on CSF Lactate and CSF L/P-Ratio in Brain Injury
Diagnostic and prognostic evaluation of patients with severe head injury by means of measurable values in an urgent and not yet satisfactorily fulfilled clinical need. In recent years changes in CSF lactate and pyruvate concentrations in patients with head injury have been pointed out by various authors with the suggestion to apply them to clinical diagnosis and prognosis. Lactacidosis and increased lactate/pyruvate ratio in CSF have been demonstrated in the pressure of serious damage of brain tissue, e. g. in patients with severe head injuries. CROCKARD and TAILOR (1) observed a correlation between the amount of CSF lactacidosis and prognosis, indicating that patients whose CSF-pH decreased below a certain level did not recover.
KeywordsHead Injury Lactate Concentration Severe Head Injury Pyruvate Concentration Ventilatory Change
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- 1.CROCKARD, H. A. and A. R. TAYLOR: Arterial CSF lactate/pyruvate values as a guide to prognosis in head injury coma. In: Cerebral Blood Flow and Intracranial Pressure. S. Karger, Basel (1972)Google Scholar