Abstract
Experimental studies have shown that cerebral perfusion pressure, i. e. the difference between mean arterial and intracranial pressure, can be lowered to about 40–60 mm Hg without marked cerebral hemodynamic or metabolic disorders (1, 2, 3). Below this limit significant decrease of cerebral blood flow and increase of cerebral tissue and jugular vein lactate concentration was noticed (4, 5, 6, 7, 8). In the above experiments low cerebral perfusion pressures were produced either by decreasing the arterial or by increasing the intracranial pressure.
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Gobiet, W., Bock, W.J., Liesegang, J., Grote, W. (1973). Intracranial Pressure, Hemodynamics and Metabolic Disorders in Patients with Severe Head Injury. In: Schürmann, K., Brock, M., Reulen, HJ., Voth, D. (eds) Brain Edema / Cerebello Pontine Angle Tumors. Advances in Neurosurgery, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65734-4_11
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DOI: https://doi.org/10.1007/978-3-642-65734-4_11
Publisher Name: Springer, Berlin, Heidelberg
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