The Pathogenesis of Tamiami Virus Meningoencephalitis in Newborn Mice
Tamiami virus produced a lethal meningoencephalitis when inoculated peripherally into 1- to 5-day-old mice, while older and younger animals were spared. Comparison of lethally and non-lethally infected animals suggested that host factors, especially the extent of inflammatory response, determined the outcome of infection. Intracellular localization of antigen-antibody complexes coincided with recovery from disease and elimination of virus and viral antigen, suggesting a beneficial, rather than deleterious role for antibody in this disease.
KeywordsFormalin Migration Hepatitis Albumin Citrate
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- 1.Borden, E.C., F.A. Murphy, N. Nathanson, and T.P.C. Monath: Effect of antilymphocyte serum on Tacaribe virus infection in infant mice. Infect. Immunity 3: 466–471 (1971).Google Scholar
- 4.Calisher, C.H., T. Tzianabos, R.D. Lord, and P.H. Coleman: Tamiami virus, a new member of the Tacaribe group. Amer. J. trop. Med. Hyg. 19: 520–526 (1970).Google Scholar
- 5.Casey, H.: Standardized diagnostic complement fixation method and adaptation to microtest. Public Health Service Monograph No. 74, publication No. 1228. Washington: U.S. Government Printing Office 1965.Google Scholar
- 7.Hotchin, J.: Persistent and Slow Virus Infections. Monographs in Virology 3. Basel, New York: S. Karger 1971.Google Scholar
- 9.Jennings, W.L., A.L. Lewis, G.E. Sather, L.V. Pierce, and J.O. Bond: Tamiami virus in the Tampa Bay area. Amer. J. trop. Med. Hyg. 19.: 527–536 (1970).Google Scholar
- 11.Lehmann-Grube, F.: Lymphocytic Choriomeningitis Virus. Virology Monographs 10. Wien, New York: springer-Verlag 1971.Google Scholar
- 15.Oldstone, M.B.A., and F.J. Dixon: Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. II. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease. J. exp. Med. 131: 1–19 (1970).PubMedCrossRefGoogle Scholar