The Pathogenesis of Tamiami Virus Meningoencephalitis in Newborn Mice
Tamiami virus produced a lethal meningoencephalitis when inoculated peripherally into 1- to 5-day-old mice, while older and younger animals were spared. Comparison of lethally and non-lethally infected animals suggested that host factors, especially the extent of inflammatory response, determined the outcome of infection. Intracellular localization of antigen-antibody complexes coincided with recovery from disease and elimination of virus and viral antigen, suggesting a beneficial, rather than deleterious role for antibody in this disease.
KeywordsViral Antigen Lymphocytic Choriomeningitis Virus Acute Inflammatory Cell Normal Mouse Brain Glial Nodule
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