The Pathogenesis of Tamiami Virus Meningoencephalitis in Newborn Mice

  • W. C. WinnJr.
  • F. A. Murphy
  • Mary R. Flemister


Tamiami virus produced a lethal meningoencephalitis when inoculated peripherally into 1- to 5-day-old mice, while older and younger animals were spared. Comparison of lethally and non-lethally infected animals suggested that host factors, especially the extent of inflammatory response, determined the outcome of infection. Intracellular localization of antigen-antibody complexes coincided with recovery from disease and elimination of virus and viral antigen, suggesting a beneficial, rather than deleterious role for antibody in this disease.


Viral Antigen Lymphocytic Choriomeningitis Virus Acute Inflammatory Cell Normal Mouse Brain Glial Nodule 
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Copyright information

© Springer-Verlag · Heidelberg 1973

Authors and Affiliations

  • W. C. WinnJr.
    • 1
  • F. A. Murphy
    • 1
  • Mary R. Flemister
    • 1
  1. 1.Center for Disease Control, Health Services and Mental Health Administration, Public Health ServiceU.S. Department of Health, Education, and WelfareAtlantaUSA

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