Summary
The inhibitory action of the M-P strain of LCM virus against mouse tumors and oncogenic viruses appears to be mediated via induced serum interferon during 2 to 5 days, followed by an immune action.
These mechanisms are more clearly elucidated in the inhibition of pseudorabies virus disease in mice by LCM(M-P) virus. Here host resistance is caused by interferon, followed by virus host-specific immunity directed against host antigens incorporated on both the LCM(M-P) virus and the pseudorabies virus, acquired during replication in mice.
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Padnos, M., Molomut, N. (1973). Inhibition of Mouse Tumors and Viruses by the M-P Strain of LCM Virus. In: Lehmann-Grube, F. (eds) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65681-1_14
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DOI: https://doi.org/10.1007/978-3-642-65681-1_14
Publisher Name: Springer, Berlin, Heidelberg
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