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Clinical and Laboratory Investigation of Combination Radiation and Chemical Therapy

  • Chapter
Antineoplastic and Immunosuppressive Agents Part I

Abstract

Therapeutic radiologists have sought means of improving radiation effects on tumors relative to normal tissues for over 50 years. Regaud (1922) demonstrated that the same biological end result could be achieved with a single large, or multiple small increments of radiation, and that the multiple smaller doses caused far less injury to normal tissues. Coutard (1926) described favorable results of the clinical application of Regaud’s work leading to the fractionated-dose radiotherapy techniques in use today. This discovery, along with dramatic advances in the physics and technology of radiation therapy and accumulated knowledge and experience in the application of this technology, have led to marked improvement in survival rates of patients with most forms of cancer. Although radiobiologists and radiation therapists have not made breakthroughs as significant as that of Regaud and Coutard, clinical investigation of methods to increase radiation response is proceeding in three major areas: (1) physiologic (i.e. increasing oxygen concentration in tumors), (2) physical (i.e. using heavy particle, high linear energy transfer radiations), and (3) chemical. The purpose of this section is to discuss the third method.

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Authors
  1. R. L. Scotte Doggett
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  2. Malcolm A. Bagshaw
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Istitutes of Health, Bethesda, Maryland, 20014, USA

    David G. Johns M. D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Doggett, R.L.S., Bagshaw, M.A. (1974). Clinical and Laboratory Investigation of Combination Radiation and Chemical Therapy. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents Part I. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65678-1_25

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  • DOI: https://doi.org/10.1007/978-3-642-65678-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65680-4

  • Online ISBN: 978-3-642-65678-1

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