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Aldosterone Regulation in Sodium Deficiency: Role of Ionic Factors and Angiotensin II

  • Chapter
Angiotensin

Abstract

This section describes the biosynthetic control of aldosterone secretion by reference to studies of humoral factors which affect aldosterone production in vivo and in vitro. The model thus built up is concerned with the processes most likely to be involved during sodium depletion. For example, Ang. II and ionic factors are considered in detail whilst the action of ACTH is treated only briefly and serotonin is only mentioned. The biosynthetic summary is then used to examine the control of aldosterone during sodium deficiency with particular attention to the role of ionic factors and the question of whether the renin-angiotensin system is the major regulator of aldosterone secretion in sodium deficiency.

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  1. J. R. Blair-West
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  2. J. P. Coghlan
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  3. D. A. Denton
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  4. B. A. Scoggins
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  1. The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    Irvine H. Page M.D. (Emeritus Director of Research) (Emeritus Director of Research)

  2. Division of Research, The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    F. Merlin Bumpus Ph.D. (Chairman) (Chairman)

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Blair-West, J.R., Coghlan, J.P., Denton, D.A., Scoggins, B.A. (1974). Aldosterone Regulation in Sodium Deficiency: Role of Ionic Factors and Angiotensin II. In: Page, I.H., Bumpus, F.M. (eds) Angiotensin. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65600-2_18

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