Measurement of “Interstitial Fluid” Pressure in the Brain in Dogs

  • P. Brodersen
  • K. Højgaard
  • N. A. Lassen


The interstitial fluid pressure is the hydrostatic pressure of the fluid between the solid tissue elements such as cells, fibers and vessels. Guyton measured negative pressures in chronically implanted perforated capsules, which he considered to be the true interstitial pressure in the subcutis [1], Others showed that a cotton wick inserted in a needle or catheter recorded a negative pressure in the subcutis within a few minutes just as the Guyton capsule did [2, 3].


Negative Pressure Fluid Pressure Brain Edema Interstitial Fluid Interstitial Fluid Pressure 
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  1. 1.
    Guyton, A. C.: A concept of negative interstitial pressure based on pressures in implanted perforated capsules. Circulat. Res. 12, 399–414 (1963).Google Scholar
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    Scholander, P. F., Hargens, A. R., Miller, S. L.: Negative pressures in the interstitial fluid of animals. Science 161, 321–328 (1968).PubMedCrossRefGoogle Scholar
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    Ladegaard-Pedersen, H. J.: Measurement of the interstitial pressure in subcutaneous tissue in dogs. Circulat. Res. 26, 765–770 (1970).Google Scholar
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Copyright information

© Springer-Verlag Berlin 1972

Authors and Affiliations

  • P. Brodersen
  • K. Højgaard
  • N. A. Lassen

There are no affiliations available

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