Measurement of “Interstitial Fluid” Pressure in the Brain in Dogs
The interstitial fluid pressure is the hydrostatic pressure of the fluid between the solid tissue elements such as cells, fibers and vessels. Guyton measured negative pressures in chronically implanted perforated capsules, which he considered to be the true interstitial pressure in the subcutis , Others showed that a cotton wick inserted in a needle or catheter recorded a negative pressure in the subcutis within a few minutes just as the Guyton capsule did [2, 3].
KeywordsCatheter Polyethylene Heparin Pentobarbital
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- 1.Guyton, A. C.: A concept of negative interstitial pressure based on pressures in implanted perforated capsules. Circulat. Res. 12, 399–414 (1963).Google Scholar
- 3.Ladegaard-Pedersen, H. J.: Measurement of the interstitial pressure in subcutaneous tissue in dogs. Circulat. Res. 26, 765–770 (1970).Google Scholar