Summary
Effects of corticosteroids in different doses on the blood-brain barrier in oil emboli-induced cerebral edema were studied by means of RISA. Initial doses of hydrocortisone and prednisolone should be about 10 mg/kg and 2 mg/kg respectively to protect or repair the blood-brain barrier which is impaired in case of cerebral edema, and smaller doses may not exhibit significant effect. Effects of prednisolone on the cellular membrane were examined by employing cultured astrocytoma cells. Swelling and vacuole-formation of astrocytoma cells in media of low osmolarity were prevented by addition of prednisolone to that medium. It is suggested that steroids are concerned with permeability of the cellular membrane, thus exerting protective effects upon the blood-brain barrier.
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References
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© 1972 Springer-Verlag Berlin · Heidelberg
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Sano, K., Hatanaka, H., Kamano, S. (1972). Steroids and the Blood-Brain Barrier with Special Reference to Astrocytic Cells. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_20
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DOI: https://doi.org/10.1007/978-3-642-65448-0_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-05958-5
Online ISBN: 978-3-642-65448-0
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