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The Role of Necrosis and Inflammation in the Response of Cerebral Edema to Steroids

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Steroids and Brain Edema

Summary

The effect of steroids on the edema associated with lesions induced by focal cerebral freezing in monkeys was assessed. The animals were sacrificed 48 h after injury. In one group treatment was begun 48 h prior to injury and in a second group treatment was begun after injury but the lesion size was reduced. The degree of edema was assessed through measurements of changes in the concentrations of tissue water, sodium, chloride, potassium, and iron and by the increase in weight of the damaged hemisphere. In addition to this the uptake of serum albumin and Evans blue was also measured. No indication of any effect on edema in either group was found.

The degree of edema in the brains of patients with unilateral metastatic tumors was assessed through measurements of hemispheric weights. It was found that those patients having a favorable neurological clinical response to steroids at the time of death had less edema than those who did not. Histologic changes in the brains of such patients were analyzed. It was found that lesions from those patients who were not responding to steroids at the time of death showed significandy more inflammation than those who were responding.

An attempt is made to define the relative roles of necrosis and inflammation in the response of cerebral edema to steroid management. It is concluded that the presence or absence of cellular inflammation is the determining factor in this response.

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Authors and Affiliations

  1. Presbyterian St. Luke’s Hospital, University of Illinois, College of Medicine, Chicago, IL, 60612, USA

    Raymond A. Clasen, Walid A. Hindo, Sylvia Pandolfi & Iris Laing

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  1. Raymond A. Clasen
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  2. Walid A. Hindo
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  3. Sylvia Pandolfi
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  4. Iris Laing
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Editors and Affiliations

  1. Neurochirurgische Universitätsklinik Mainz, 6500, Mainz, Langenbeckstr. 1, W. Germany

    H. J. Reulen  & K. Schürmann  & 

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Clasen, R.A., Hindo, W.A., Pandolfi, S., Laing, I. (1972). The Role of Necrosis and Inflammation in the Response of Cerebral Edema to Steroids. In: Reulen, H.J., Schürmann, K. (eds) Steroids and Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65448-0_18

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  • DOI: https://doi.org/10.1007/978-3-642-65448-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-05958-5

  • Online ISBN: 978-3-642-65448-0

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