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Effects of Steroids on Edema Associated with Injury of the Spinal Cord

  • Marcial G. Lewin
  • Hanna M. Pappius
  • Robert R. Hansebout

Summary

Standardized spinal cord injury was produced in cats by impact. Some were untreated and others treated with dexamethasone before and up to 24 h after injury.

The neurological condition of the cats was rated throughout the experimental period. Water and electrolyte content determinations and histological observations were made of injured spinal cord tissue.

Edema as demonstrated by increasing water content of the injured tissues begins a day after injury and thence increases significantly to a maximum three to six days after the trauma when segments adjacent to the lesion are involved. Edema has begun to recede on the ninth day.

Cats treated with dexamethasone before or up to 24 h after cord injury have significandy better recovery and less histological abnormality in the spinal cord than untreated cats, but the course of post-traumatic edema is similar. The beneficial effects of dexamethasone on functional recovery of animals with potentially reversible cord lesions does not seem to be mediated by its effects on edema alone.

Keywords

Spinal Cord White Matter Spinal Cord Injury Potassium Concentration Injured Spinal Cord 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Marcial G. Lewin
    • 1
  • Hanna M. Pappius
    • 1
  • Robert R. Hansebout
    • 1
  1. 1.Department of Neurology and Neurosurgery and the Donner Laboratory for Experimental Neurochemistry, The Montreal Neurological InstituteMcGill UniversityMontrealCanada

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