Current Aspects of Bacterial Enterotoxins

  • Daniel G. Sheahan
Conference paper
Part of the Current Topics in Pathology / Ergebnisse der Pathologie book series (CT PATHOLOGY, volume 56)


It is a curious fact of medical history that entero (exo) toxin production by a wide variety of enteric pathogens has been appreciated only within the past decade while the pathogens themselves have been recognized since the beginning of bacteriology. Recent investigations have implicated toxins produced by Staphylococcus aureus, Vibrio cholerae, certain strains of “non-pathogenic” Escherichia coli, as well as Shigella dysenteriae, C. perfringens and possibly Pseudomonas aeruginosa as being responsible for diarrheal disease.


Cholera Toxin Staphylococcal Enterotoxin Current Aspect Enterotoxin Production Cholera Patient 
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  1. Al-Awqati, Q., Cameron, J. L., Field, M., Greenough, W. B. III: Response of human ileal mucosa to choleragen and theophylline. J. clin. Invest. 49, 2a (1970a).Google Scholar
  2. Al-Awqati, Q., Field, M., Pierce, N. F., Greenough, W. B.: Effect of prostaglandin E1 (PGE1) on electrolyte transport in rabbit ileal mucosa. J. clin. Invest. 49, 2a (1970b).Google Scholar
  3. Al-Awqati, Q., Greenough, W. B., Carpenter, C. C. J.: Ethacrynic acid inhibits gut fluid loss in cholera. Clin. Res. 17, 422 (1969).Google Scholar
  4. Arm, H. G., Floyd, T. M., Faber, J. E., Haytes, J. R.: Use of ligated segments of rabbit small intestine in experimental shigellosis. J. Bact. 89, 803–809 (1965).PubMedGoogle Scholar
  5. Avena, R. M., Bergdoll, M. S.: Purification and some physicochemical properties of enterotoxin C, staphylococcus aureus strain 361. Biochemistry 6, 1474–1480 (1967).PubMedGoogle Scholar
  6. Baird-Parker, A. C, Joseph, R. L.: Fractionation of staphylococcal enterotoxin B. Nature (Lond.) 202, 570–571 (1964).Google Scholar
  7. Baker, A. L., Kaplan, M. M., Kimberg, D. V., Pierce, N. F.: Stimulation of rat liver enzyme activity by intravenous cholera toxin. Gastroenterology 60, 739 (1971).Google Scholar
  8. Banwell, J. G., Gorbach, S. L., Pierce, N. F., Mitra, R., Mondal, A.: Acute undifferentiated human diarrhea in the tropics. II. Alterations in intestinal fluid and electrolyte movements. J. clin. Invest. 50, 890–900 (1971).PubMedGoogle Scholar
  9. Banwell, J. G., Pierce, N. F., Mitra, R. C, Brigham, K. L., Caranasos, G. J., Keimowitz, R. I., Fedson, D. S., Thomas, J., Gorbach, S. L., Sack, R. B., Mondal, A.: Intestinal fluid and electrolyte transport in human cholera. J. clin. Invest. 49, 183–195 (1970).PubMedGoogle Scholar
  10. Basu, S., Pickett, M. J.: Chinchilla: A new host for choleragenic vibrios. Bact. Proc. p. 75 (1969).Google Scholar
  11. Basu, S., Robinson, R. L., Pickett, M. J.: Preliminary studies on the bioassay of anticholera vaccines in chinchillas. J. infect. Dis. 121, Suppl. S56–S57 (1970).PubMedGoogle Scholar
  12. Basu Mallick, K. C, Bannerjee, P. L., Mallick, D. C, Ghosh, E., Mondal, A.: Active principles in cholera stool. Indian J. med. Res. 57, 983–987 (1969).PubMedGoogle Scholar
  13. Basu Mallick, K. C, Ganguli, N. C.: Some observations on the pathogenesis of cholera. Indian J. med. Res. 52, 894–901 (1964).Google Scholar
  14. Bayless, T. M., Luebbers, E., Elliott, H. L.: Immature jejunal crypts: Absence of response to stimulus for fluid secretion. Gastroenterology 60, 762 (1971).Google Scholar
  15. Benenson, A. S., Mosley, W. H., Fahimuddin, M., Oseasohn, R. O.: Cholera vaccine field trials in East Pakistan. 2. Effectiveness in the field. Bull. Wld Hlth Org. 38, 359–372 (1968c).Google Scholar
  16. Benenson, A. S., Saad, A., Mosley, W. H.: Serological studies in cholera. 2. The vibriocidal antibody response of cholera patients determined by a microtechnique. Bull. Wld Hlth Org. 38, 277–285 (1968b).Google Scholar
  17. Benenson, A. S., Saad, A., Mosley, W. H.: Ahmed, A.: Serological studies in cholera. 3. Serum toxin neutralization — rise in titre in response to infection with vibrio cholerae and the level in the “normal” population of East Pakistan. Bull. Wld Hlth Org. 38, 287–295 (1968a).Google Scholar
  18. Bengtsson, S., Berg, R., Danielsson, D., Landmark, K. M., Norbring, F., Sandler, O.: En vattenburen epidemi med enteropatagena Escherichia coli. Lakartidningen 63, 4499–4506, 1966.PubMedGoogle Scholar
  19. Benyajati, C: Experimental cholera in humans. Brit. med. J. 1966I, 140–142.Google Scholar
  20. Bergdoll, M. S.: Immunization of rhesus monkeys with enterotoxoid B. J. infect. Dis. 116, 191–196 (1966).PubMedGoogle Scholar
  21. Bergdoll, M. S.: Enterotoxins, In: Microbial toxins: Bacterial protein toxins. Edit. Montie, T. C, Kadis, S., and Ajl, S. J. Vol. II, p. 265–326. New York: Academic Press 1970.Google Scholar
  22. Bergdoll, M. S.: Borja, C. R., Avena, R. M.: Identification of a new enterotoxin as enterotoxin C. J. Bact. 90, 1481–1485 (1965).PubMedGoogle Scholar
  23. Bergdoll, M. S., Sugiyama, H., Dack, G. M.: Staphylococcal enterotoxin purification. Arch. Biochem. 85, 62–69 (1959).PubMedGoogle Scholar
  24. Bergdoll, M. S., Weiss, K. F., Muster, M. J.: The production of staphylococcal enterotoxin by a coagulase negative microorganism. Bact. Proc. p. 12 (1967).Google Scholar
  25. Bhattacharya, P. K., Chowdhury, J. R., Datta, A. G.: Studies on the inhibitory effect of erythrose on the development of experimental cholera. Brit. med. J. 2, 1965II,1351.Google Scholar
  26. Bhoola, K. D., Calle, J. D., Schachter, M.: The effect of bradykinin, serum kallikrein and other endogenous substances on capillary permeability in the guinea pig. J. Physiol. (Lond.) 152, 75–86 (1960).Google Scholar
  27. Borja, C. R., Bergdoll, M. S.: Purification and partial characterization of enterotoxin C produced by staphylococcus aureus strain 137. Biochem. (Wash.) 6, 1467–1473 (1967).Google Scholar
  28. Borja, C. R., Bergdoll, M. S.: Staphylococcal enterotoxin C. II. Some physical, immunological, and toxic properties. Biochemistry 8, 75–79 (1969).PubMedGoogle Scholar
  29. Bowden, J. P.: A method of preparing small quantities of 14C-labelled staphylococcal enterotoxin B. Biochim. Biophys. Acta (Amst.) 168, 150–152 (1968).Google Scholar
  30. Branham, S. E., Dack, G. M., Riggs, D. B.: Studies with shigella dysenteriae (Shiga). IV. Immunological reactions in monkeys to the toxins in isolated intestinal pouches. J. Immunol. 70, 103–113 (1953).PubMedGoogle Scholar
  31. Braun, O. H., Henckel, H.: Säuglingsenteritis durch pathogene Colitypen, insbesondere E. Coli 55/B5. Z. Kinderheilk. 70, 273–285 (1952).Google Scholar
  32. Breckenridge, J. C, Bergdoll, M. S.: Foodborne gastroenteritis due to coagulase negative staphylococcus. New Engl. J. Med. 284, 541–543 (1971).Google Scholar
  33. Burrows, W.: Cholera toxins.: Ann. Rev. Microbiol. 22, 245–268 (1968).Google Scholar
  34. Burrows, W.: Toward an effective prophylactic immunity to cholera. J. infect. Dis. 12, Suppl. S58–S61 (1970).Google Scholar
  35. Burrows, W.: Musteikis, G. M., Oza, N. B., Dutta, N. K.: Cholera toxins: Quantitation of the frog skin reaction and its relation to experimental enteric toxicity. J. infect. Dis. 115, 1–8 (1965).PubMedGoogle Scholar
  36. Burrows, W.: Wagner, S. M., Mather, A. N.: The endotoxin of the cholera vibrio: Action on living semipermeable membranes. Proc. Soc. exp. Biol. (N.Y.) 57, 311-314 (1944).Google Scholar
  37. Butcher, R. W., Baird, C. E.: Effects of prostaglandins on adenosine 3’5’ monophosphate levels in fat and other tissues. J. biol. Chem. 243, 1713–1717 (1968).PubMedGoogle Scholar
  38. Butcher, R. W., Sutherland, E. W.: Adenosine 3’5’ phosphate in biological material. I. Purification and properties of cyclic 3’5’ nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3’5’ phosphate in human urine. J. biol. Chem. 237, 1244–1250 (1962).PubMedGoogle Scholar
  39. Carpenter, C. C. J.: Cholera enterotoxin — recent investigations yield insights into transport processes. Amer. J. Med. 50, 1–7 (1971).PubMedGoogle Scholar
  40. Carpenter, C. C. J.: Barua, D., Sack, R. B., Wallace, C. K., Mitra, P. P., Khanra, S. R., Werner, T. S., Duffy, T. E., Oleinick, A.: Clinical studies in Asiatic cholera. V. Shock producing acute diarrheal disease in Calcutta: A clinical and biochemical comparison of cholera with severe non-cholera diarrhea 1963–1964. Bull. Johns Hopk. Hosp. 118, 230–242 (1966).Google Scholar
  41. Carpenter, C. C. J.: Chaudhuri, R. N., Mondal, A.: A simple effective therapy of cholera. Indian J. med. Res. 52, 924–932 (1964).PubMedGoogle Scholar
  42. Carpenter, C. C. J.: Curlin, G. T., Greenough, W. B. III.: Response of canine thiry-vella jejunal loops to cholera exotoxin and its modification by ethacrynic acid. J. infect. Dis. 120, 332–338 (1969b).PubMedGoogle Scholar
  43. Carpenter, C. C. J.: Greenough, W. B. III.: Response of the canine duodenum to intraluminal challenge with cholera exotoxin. J. din. Invest. 47, 2600–2607 (1968).Google Scholar
  44. Carpenter, C. C. J.: Greenough, W. B. III.: Sack, R. B.: The relationship of superior mesenteric artery blood flow to gut electrolyte loss in experimental cholera. J. infect. Dis. 119, 182–193 (1969a).PubMedGoogle Scholar
  45. Carpenter, C. C. J., Sack, R. B., Feeley, J. C, Steenburg, R. W.: Site and characteristics of electrolyte loss and effect of intraluminal glucose in experimental canine cholera. J. clin. Invest. 47, 1210–1220 (1968).PubMedGoogle Scholar
  46. Gasman, E. P.: Further serological studies of staphylococcal enterotoxin. J. Bact. 79, 849–856 (1960).Google Scholar
  47. Gasman, E. P.: Staphylococcal enterotoxin. Ann. N.Y. Acad. Sci. 128, 124–131 (1965).Google Scholar
  48. Gasman, E. P.: Bennett, R. W.: Culture medium for the production of staphylococcal enterotoxin A. J. Bact. 86, 18–23 (1963).Google Scholar
  49. Gasman, E. P.: Bennett, R. W.: Detection of staphylococcal enterotoxin in food. Appl. Microbiol. 13, 181–189 (1965).Google Scholar
  50. Gasman, E. P.: Bennett, R. W.: Dorsey, A. E., Issa, J. A.: Identification of a fourth staphylococcal enterotoxin, enterotoxin D. J. Bact. 94, 1875–1882 (1967).Google Scholar
  51. Gasman, E. P.: Bergdoll, M. S., Robinson, J.: Designation of staphylococcal enterotoxins. J. Bact. 85, 715–716 (1963).Google Scholar
  52. Chen, L. C., Rohde, J. E., Sharp, G. W. G.: Intestinal adenylcyclase activity in human cholera. Lancet 1971I, 939–941.Google Scholar
  53. Chowdhury, R. J., Datta, A. G.: Studies on the growth inhibitory effect of erythrose on vibrio cholerae. Biochim. biophys. Acta (Amst.) 104, 296–298 (1965).Google Scholar
  54. Chu, F. S.: Hydrogen ion equilibria of staphylococcal enterotoxin B. J. biol. Chem. 243, 4342–4349 (1968).PubMedGoogle Scholar
  55. Chu, F. S: Crary, E., Bergdoll, M. S.: Chemical modification of amino groups in staphylococcal enterotoxin B. Biochemistry 8, 2890–2896 (1969).PubMedGoogle Scholar
  56. Chu, F. S.: Thadhani, K., Schantz, E. J., Bergdoll, M. S.: Purification and characterization of staphylococcal enterotoxin A. Biochemisty 5, 3281-3289 (1966).Google Scholar
  57. Clarke, W. G., Vanderhooft, G. F., Borison, H. L.: Emetic effect of purified staphylococcal enterotoxin in cats. Proc. Soc. exp. Biol. (N.Y.) 111, 205–207 (1962).Google Scholar
  58. Cohnheim, J. F.: Lectures on general pathology. A handbook for practitioners and students. Section III. The pathology of digestion (1882) (translated from the second German edition by A. B. McKee). New Syndenhan Soc. (Lond.) 133, 949–960 (1890).Google Scholar
  59. Coleman, W. H., Kaur, J., Iwert, M. E., Kasai, G. J., Burrows, W.: Cholera toxins: Purification and preliminary characterization of ileal loop reactive type 2 toxin. J. Bact. 96, 1137–1143 (1968).PubMedGoogle Scholar
  60. Conradi, H.: Über lösliche, durch aseptische Autolyse erhaltene Giftstoffe von Ruhrund Typhusbazillen. Dtsch. med. Wschr. 29, 26–28 (1903).Google Scholar
  61. Costin, I. D., Voiculescu, D., Gorcea, V.: An outbreak of food poisoning in adults associated with E. coli serotype O86:B7:H34. Path, et Microbiol. (Basel) 27, 68–78 (1964).Google Scholar
  62. Cotillo, L. G.: Tentativas de inhibicion de la sintesis de enterotoxina estafilococcia por penicilina y estreptomicina. Rev. Saude Publ. S. Paulo 1, 188–192 (1967).Google Scholar
  63. Cotran, R. S., Majno, G.: The delayed and prolonged vascular leakage in inflammation. I. Topography of the leaking vessels after thermal injury. Amer. J. Path. 45, 261–181 (1964).PubMedGoogle Scholar
  64. Crabbé, P. A., Nash, D. R., Bazin, H., Eyssen, H., Heremans, J. F.: Antibodies of the IgA type in intestinal plasma cells of germfree mice after oral or parenteral immunization with ferritin. J. exp. Med. 130, 723–744 (1969).PubMedGoogle Scholar
  65. Craig, J. P.: A permeability factor (toxin) found in cholera stools and culture filtrates and its neutralization by convalescent cholera sera. Nature (Lond.) 207, 614–616 (1965a).Google Scholar
  66. Craig, J. P.: The effect of cholera stool and culture filtrates on the skin of guinea pigs and rabbits. In: Proceedings of the Cholera Research Symposium USPHS Publication 1328, p. 153–158. Washington, D. C: U. S. Government Printing Office 1965 b.Google Scholar
  67. Craig, J. P.: Preparation of the vascular permeability factor of vibrio cholerae. J. Bact. 92, 793–795 (1966).PubMedGoogle Scholar
  68. Craig, J. P.: Some observations on the neutralization of cholera vascular permeability factor in vivo. J. infect. Dis. 121, S100-S110 (1970).Google Scholar
  69. Craig, J. P.: Cholera toxins. Microbial toxins: Bacterial Protein Toxins, vol. IIA, p. 189–254. New York: Academic Press 1971.Google Scholar
  70. Cramblett, H. G., Azimi, P., and Haynes, R. E: The etiology of infectious disease in infancy with special reference to enteropathogenic E. coli. Ann. N.Y. Acad. Sci. 176, 80–92 (1971).Google Scholar
  71. Crawley, G. J., Black, J. N., Gray, I., Blanchard, J. W.: Clinical chemistry of staphylococcal enterotoxin poisoning in monkeys. Appl. Microbiol. 14, 445–450 (1966a).PubMedGoogle Scholar
  72. Crawley, G. J., Gray, I., LeBlang, W. A., Blanchard, J. W.: Bloodbinding, distribution and excretion of staphylococcal enterotoxin in monkeys. J. infect. Dis. 116, 48–56 (1966b).PubMedGoogle Scholar
  73. Curlin, G. T., Carpenter, C. J.: Antitoxic immunity to cholera in isolated perfused canine ileal segmants. J. infect. Dis. 121, Suppl. S132–S136 (1970).Google Scholar
  74. Curlin, G. T., Chen, L. C.: Cholera toxin stimulation of rat lipocyte adenyl cyclase activity. Clin. Res. 19, 456 (1971).Google Scholar
  75. Curlin, G. T., Craig, J. P., Subong, A., Carpenter, C. C. J.: Antitoxic immunity in experimental canine cholera. J. infect. Dis. 121, 463–470 (1970).PubMedGoogle Scholar
  76. Curlin, G. T., Subong, A., Craig, J. P., Carpenter, C. C. J.: Antitoxic immunity in experimental canine cholera. Trans. Ass. Amer. Phycns 81, 314–322 (1968).Google Scholar
  77. Dack, G. M.: Food poisoning. Chicago: Chicago University of Press 1956.Google Scholar
  78. Dack, G. M.: Microbial Food Poisoning. Food Technol. 18, 1904–1906 (1964).Google Scholar
  79. Dack, G. M.: Jordan, E. O., Woolpert, O.: Attempts to immunize human volunteers with staphylococcus filtrates that are toxic to man when swallowed. J. Prevent. Med. (Baltimore) 5, 151–159 (1931).Google Scholar
  80. Dack, G. M.: Sugiyama, H., Owens, F. J., Kirsner, J. B.: Failure to Produce Illness in Human Volunteers Fed Bacillus Cereus and Clostridium Perfringens. J. infect. Dis. 94, 34–38 (1954).PubMedGoogle Scholar
  81. Dalidowicz, J. E., Silverman, S. J., Schantz, E. J., Stefanye, D., Spero, L.: Chemical and biological properties of reduced and alkylated staphylococcal enterotoxin B. Biochemistry 5, 2375–2381 (1966).PubMedGoogle Scholar
  82. Dalldorf, F. G., Keusch, G. T., Livingston, H. L.: Transcellular permeability of capillaries in experimental cholera. Amer. J. Path. 57, 153–170 (1969).PubMedGoogle Scholar
  83. Danielsson, D., Laurrell, G., Sjolin, S.: An outbreak of diarrhea due to enteropathogenic E. coli studied by means of fluorescent antibody identification and conventional bacteriological culture. Acta paediat. scand. 54, 432–438 (1965).PubMedGoogle Scholar
  84. De, S. N.: Enterotoxicity of bacteria-free culture filtrates of vibrio cholerae. Nature (Lond.) 183,1533–1534(1959).Google Scholar
  85. De, S. N.: Bhattacharya, K., Sarkar, J. K.: A study of the pathogenicity of strains of bacterium coli from acute and chronic enteritis. J. Path. Bact. 71, 201–209 (1956).PubMedGoogle Scholar
  86. De, S. N.: Chatterje, D. N.: An experimental study of the mechanism of action of vibrio cholerae on the intestinal mucous membrane. J. Path. Bact. 66, 559–562 (1953).PubMedGoogle Scholar
  87. De, S. N.: Ghose, M. L., Chandra, J.: Further observations on cholera enterotoxin. Trans. Roy. Soc. Trop. Med. Hyg. 56, 241–245 (1962).PubMedGoogle Scholar
  88. De, S. N.: Ghose, M. L., Sen, A.: Activities of bacteria-free preparations from vibrio cholerae. J. Path. Bact. 79, 373–380 (1960).PubMedGoogle Scholar
  89. Deycke, G.: Über histologische und bacilläre Verhältnisse im Choleradarm: Dtsch. med. Wschr. 18, 1048–1049 (1892).Google Scholar
  90. Dische, F. E, Elek, S. D.: Experimental Food Poisoning by Clostridium Welchii. Lancet 1957II, 71–74.Google Scholar
  91. Dolman, C. E.: Ingestion of staphylococcus exotoxin by human volunteers. J. infect. Dis. 55, 172–183 (1934).Google Scholar
  92. Dolman, C. E.: Bacterial food poisoning. Canad. J. publ. Hlth 34, 205 (1943).Google Scholar
  93. Dolman, C. E.: Antigenic properties of staphylococcus enterotoxin. Canad. J. publ. Hlth 35, 337–351 (1944).Google Scholar
  94. Dolman, C. E.: Wilson, R. J.: Experiments with staphylococcal enterotoxin. J. Immunol. 35, 13–30 (1938).Google Scholar
  95. Dolman, C. E.: Wilson, R. J.: Kitten test for staphylococcus enterotoxin. Canad. pub. Hlth J. 31,68–71 (1940).Google Scholar
  96. Dornbusch, K., Hallander, H. O., Lofquist, F.: Extrachromosomal control of methicillin resistance and toxin production in staphylococcus aureus. J. Bact. 98, 351–358 (1969).PubMedGoogle Scholar
  97. Drees, D. T., Waxler, G. L.: Enteric colibacillosis in gnotobiotic swine: An electron microscopic study. Amer. J. vet. Res. 31, 1160–1171 (1970).Google Scholar
  98. Drucker, M. M., Yeivin, R., Sacks, T. G.: Pathogenesis of Escherichia coli enteritis in the ligated rabbit gut. Israel J. med. Sci. 3, 445–452 (1967).PubMedGoogle Scholar
  99. Duhamel, R. C, Talbot, P., Grady, G. F.: Production, purification and assay of cholera enterotoxin. J. infect. Dis. 121, Suppl. S85–S91 (1970).Google Scholar
  100. Duncan, C. L., Strong, D. H.: Improved Medium for Sporulation of Clostridium Perfringens. Appl. Microbiol. 16, 82–89 (1968).PubMedGoogle Scholar
  101. Duncan, C. L., Strong, D. H.: Experimental Production of Diarrhea in Rabbits with Clostridium Perfringens. Canad. J. Microbiol. 15, 765–770 (1969a).Google Scholar
  102. Duncan, C. L., Strong, D. H.: Ileal Loop Fluid Accumulation and Production of Diarrhea in Rabbits by Cell-Free Products of Clostridium Perfringens. J. Bact. 100, 86–94 (1969b).PubMedGoogle Scholar
  103. Duncan, C. L., Sugiyama, H., Strong, D. H.: Rabbit Ileal Loop Response to Strains of Clostridium Perfringens. J. Bact. 95, 1560–1566 (1968).PubMedGoogle Scholar
  104. Dupont, H. L., Formal, S. B., Hornick, R. B., Snyder, M. J., Libonati, J. P., Sheahan, D. G., Labrec, E.H., Kalas, J. P.: Pathogenesis of Escherichia coli diarrhea. New Engl. J. Med. 285, 1–9 (1971).PubMedGoogle Scholar
  105. Dutt, A. R.: Enterotoxic activity in cholera stool. Indian J. med. Res. 53, 605–609 (1965).PubMedGoogle Scholar
  106. Dutt, A. R.: Study of ligated rabbit-gut segment and its content after introduction of v. cholerae and its culture filtrate. Indian J. med. Res. 54, 431–436 (1966).Google Scholar
  107. Dutt, A. R.: Serological studies in cholera. Indian J. med. Res. 55, 299–307 (1967).PubMedGoogle Scholar
  108. Dutt, A. R.: Mondal, A., De, S. N.: Some observations on the pathology of cholera intestine. Indian J. med. Res. 52, 902–907 (1964).PubMedGoogle Scholar
  109. Dutta, N. K., Habbu, M. K.: Experimental cholera in infant rabbits: A method for chemotherapeutic investigation. Brit. J. Pharmacol. 10, 153–159 (1955).PubMedGoogle Scholar
  110. Dutta, N. K., Oza, N. B.: The effect of gastointestinal enzymes on cholera toxin. Bull. Wld Hlth Org. 28, 307–310 (1963).Google Scholar
  111. Dutta, N. K., Panse, M. V., Kulkarni, D. R.: Role of cholera toxin in experimental cholera. J. Bact. 78, 594–595 (1959).PubMedGoogle Scholar
  112. Edwards, P. R., Ewing, W. H.: Identification of enterobacteriaceae. Second, ed. Minneapolis: Burgess Publishing Co. 1962.Google Scholar
  113. Elder, J. M., Miles, A. A.: The action of the lethal toxins of gas gangrene Clostridia on capillary permeability. J. Path. Bact. 74, 133–145 (1957).Google Scholar
  114. Elliott, H. L., Carpenter, C. C, Sack, R. B., Yardley, J. H.: Small bowel morphology in experimental canine cholera. A light and electron microscopic study. Lab. Invest. 22, 112–120 (1970.)PubMedGoogle Scholar
  115. Evans, J. B., Beuttner, L. G., Niven, C. F., Jr.: Evaluation of the coagulase test in the study of staphylococci associated with food poisoning. J. Bact. 60,481–484 (1950).PubMedGoogle Scholar
  116. Evans, D. J., Richardson, S. H.: Nutritional factors governing the production of an ion translocase inhibitor by vibrio cholerae. Bact. Proc. p. 88 (1967).Google Scholar
  117. Evans, D. J., Richardson, S. H.: In vitro production of choleragen and vascular permeability factory by vibrio cholerae. J. Bact. 96, 126–130 (1968).PubMedGoogle Scholar
  118. Ewing, W. H., Davis, B. R., Montague, T. J.: Studies on the occurrence of E. coli serotypes associated with diarrheal disease. National Communicable Disease Center, Atlanta, Georgia (1963).Google Scholar
  119. Favorite, G. O., Hammon, W. McD.: Production of staphylococcus enterotoxin and alpha hemolysin in simplified medium. J. Bact. 41, 305–316 (1941).PubMedGoogle Scholar
  120. Feeley, J. C, Roberts, C. O.: Immunological responses of laboratory animals to cholera vaccines, toxin and toxoid. Tex. Rep. Biol. Med. 27, 213–226 (1969).Google Scholar
  121. Felsenfeld, O., Burrows, W., Kasai, G. J., Greer, W. E., Jiricka, Z.: The cellular immune response of non-human primates to crude type 2 cholera toxin. J. infect. Dis. 118, 491–499 (1968).PubMedGoogle Scholar
  122. Felsenfeld, O., Nasuniya, N.: Staphylococcal antitoxin values in the sera of permanent residents and visitors in Thailand. J. trop. Med. Hyg. 67, 300-303 (1964).PubMedGoogle Scholar
  123. Ferguson, W. W., June, R. C.: Experiments on feeding adult volunteers with Escherichia coli III, B4, a coliform organism associated with infant diarrhea. Amer. J. Hyg. 55, 155–169 (1952).PubMedGoogle Scholar
  124. Field, M.: Intestinal secretion: Effect of cyclic AMP and its role in cholera. New Engl. J. Med. 284, 1137–1144 (1971).Google Scholar
  125. Field, M.: Fromm, D., Wallace, C. K., Greenough, W. B. III.: Stimulation of active chloride secretion in small intestine by cholera exotoxin. J. clin. Invest. 48, 24 a (1969).Google Scholar
  126. Field, M.: Plotkin, G. R., Silen, W.: Effects of vasopressin, theophylline and cyclic adenosine monophosphate on short circuit current across isolated rabbit ileal mucosa. Nature (Lond.) 217, 469–471 (1968).Google Scholar
  127. Finegold, M. J.: Interstitial pulmonary edema. An electron microscopic study of the pathology of staphylococcal enterotoxemia in Rhesus monkeys. Lab. Invest. 16, 912–924 (1967).PubMedGoogle Scholar
  128. Finkelstein, R. A.: Antitoxic immunity in experimental cholera: Observations with purified antigens and the ligated ileal loop model. Infect. Immun. 1, 464–467 (1970).PubMedGoogle Scholar
  129. Finkelstein, R. A.: Atthasampunna, P.: Immunity against experimental cholera. Proc. Soc. exp. Biol. (N.Y.) 125, 465–469 (1967).Google Scholar
  130. Finkelstein, R. A.: Atthasampunna, P.: Chulasamaya, M., Charunmethee, P.: Pathogenesis of experimental cholera: Biologic activities of purified procholeragen A. J. Immunol. 96, 440–449 (1966b).PubMedGoogle Scholar
  131. Finkelstein, R. A.: Hollingsworth, R. C.: Antitoxic immunity in experimental cholera: Observations with purified antigens and the rat foot edema model. Infec. Immun. 1, 468–473 (1970).Google Scholar
  132. Finkelstein, R. A.: Jehl, J. J., Goth, A.: Pathogenesis of experimental cholera: Choleragen induced rat foot edema; a method of screening anticholera drugs. Proc. Soc. exp. Biol, (N.Y.) 132, 835–840 (1969).Google Scholar
  133. Finkelstein, R. A.: LoSpalluto, J. J.: Pathogenesis of experimental cholera. Preparation and isolation of choleragen and choleragenoid. J. exp. Med. 130, 185–202 (1969).PubMedGoogle Scholar
  134. Finkelstein, R. A.: LoSpalluto, J. J.: Production of highly purified choleragen and choleragenoid. J. infect. Dis. 121, S64–S72 (1970).Google Scholar
  135. Finkelstein, R. A.: Mukerjee, S., Rudra, B. C.: Demonstration and quantitation of antigen in cholera stool filtrates. J. infect. Dis. 113, 99–104 (1963).PubMedGoogle Scholar
  136. Finkelstein, R. A.: Norris, H. T., Dutta, N. K.: Pathogenesis of experimental cholera in infant rabbits. I. Observations on the intraintestinal infection and experimental cholera produced with cell free products. J. infect. Dis. 114, 203–216 (1964).PubMedGoogle Scholar
  137. Finkelstein, R. A.: Nye, S.W., Atthasampunna, P., Charunmethee, P.: Pathogenesis of experimental cholera: Effect of choleragen on vascular permeability. Lab. Invest. 15, 1601–1609 (1966c).PubMedGoogle Scholar
  138. Finkelstein, R. A.: Sobocinski, P. Z., Atthasampunna, P., Charunmethee, P.: Pathogenesis of experimental cholera; identification of choleragen (Procholeragen A) by disc Immunoelectrophoresis and its differentiation from cholera mucinase. J. Immunol. 96, 440–449 (1966a).PubMedGoogle Scholar
  139. Flexner, S., Sweet, J. E.: The pathogenesis of experimental colitis and the relation of colitis in animal and man. J. exp. Med. 8, 514–535 (1906).PubMedGoogle Scholar
  140. Fordtran, J. S.: Speculations on the pathogenesis of diarrhea. Fed. Proc. 26, 1405–1414 (1967).PubMedGoogle Scholar
  141. Formal, S. B., Dammin, G., Sprinz, H., Kundel, D., Schneider, EL, Horowitz, R. E., Forbes, M.: Experimental shigella infections. V. Studies in germ-free guinea pigs. J. Bact. 82, 284–287 (1961).PubMedGoogle Scholar
  142. Formal, S. B., Dupont, H. L., Hornick, R., Snyder, M. J., Libonati, J., Labrec, E.H.: Experimental models in the investigation of the virulence of dysentery bacilli and Escherichia coli. Ann. N. Y. Acad. Sci. 176, 190–196 (1971).Google Scholar
  143. Formal, S. B., Dupont, H. L., Kent, T. H., Austin, S., Labrec, E. H.: Fluorescent—Antibody and histologic study of vaccinated and control monkeys challenged with shigella flexneri. J. Bact. 91, 2368–2376 (1966).PubMedGoogle Scholar
  144. Formal, S. B., Kundel, D., Schneider, H., Kunev, N., Sprinz, H.: Studies with vibrio cholerae in the ligated loop of the rabbit intestine. Brit. J. exp. Path. 42, 504–510 (1961).PubMedGoogle Scholar
  145. Formal, S. B., Labrec, E. H., Schneider, H.: Pathogenesis of bacillary dysentery in laboratory animals. Fed. Proc. 24, 29–34 (1965).PubMedGoogle Scholar
  146. Fraenkel, E.: Über Choleraleichenbefunde. Dtsch. med. Wschr. 19, 157–159 (1893).Google Scholar
  147. Frea, J. I., McCoy, E., Strong, F. M.: Purification of type B staphylococcal entero-toxin. J. Bact. 86, 1308–1313 (1963).PubMedGoogle Scholar
  148. Freeman, J. A.: Fine structure of the goblet cell mucosus secretory process. Anat. Rec. 144, 341–345 (1962).PubMedGoogle Scholar
  149. Fresh, J. W., Versage, P.M., Reyes, V.: Intestinal morphology in human and experimental cholera. United States Naval Medical Research Report. MR 005.09 to 1040.1.12, 1–10 (1963).Google Scholar
  150. Fresh, J. W., Versage, P.M., Reyes, V.: Intestinal morphology in human and experimental cholera. Arch. Path. 77, 529–537(1964).PubMedGoogle Scholar
  151. Freter, R.: Coproantibody and bacterial antagonism as protective factors in experimental enteric cholera. J. exp. Med. 104, 419–426 (1956).PubMedGoogle Scholar
  152. Freter, R.: Comparison of immune mechanisms in various experimental models of cholera. Bull. Wld Hlth Org. 31, 825–834 (1964).Google Scholar
  153. Freter, R.: Smith, H. L., Sweeney, F. J.: An evaluation of intestinal fluids in the pathogenesis of cholera. J. infect. Dis. 109, 35–42 (1961).PubMedGoogle Scholar
  154. Friedman, M. E.: Inhibition of staphylococcal enterotoxin B formation in broth cultures. J. Bact. 92, 277–278 (1966).PubMedGoogle Scholar
  155. Friedman, M. E.: Inhibition of staphylococcal enterotoxin B formation by cell wall blocking agents and other compounds. J. Bact. 95, 1051–1055 (1968).PubMedGoogle Scholar
  156. Friedman, M. E.: Howard, M. B.: Induction of mutants of staphylococcus aureus 100 with increased ability to produce enterotoxin A. J. Bact. 106, 289–291 (1971).PubMedGoogle Scholar
  157. Friedman, M. E.: White, J. D.: Immunofluorescent demonstration of cell-associated staphylococcal enterotoxin B. J. Bact. 89, 1155 (1965).PubMedGoogle Scholar
  158. Fuhrman, F. A., Fuhrman, G. J., Burrows, W.: Action and properties of an inhibitor of active transport of sodium produced by cholera vibrios. J. infect. Dis. 111, 225–232 (1962).PubMedGoogle Scholar
  159. Fuhrman, G. J., Fuhrman, F. A.: Inhibition of active sodium transport by cholera toxin. Nature (Lond.) 188, 71–72 (1960).Google Scholar
  160. Fukumi, H., Kosakai, N.: Disease producing effect of coliform organisms. Nikonlji-Shimpo, No 1506, 914 (1954), (cited by Sakazaki et al. 1967).Google Scholar
  161. Gangarosa, E. J., Beisel, W. R., Benyajati, C, Sprinz, H., Piyaratn, P.: The nature of the gastrointestinal lesion in Asiatic cholera and its relation to pathogenesis. A biopsy study. Amer. J. trop. Med. Hyg. 9, 125–135 (1960).Google Scholar
  162. Gangarosa, E. J., Dewitt, W. E., Feeley, J. C, Adams, M. R.: Significance of vibriocidal antibodies with regard to immunity to cholera. J.infect.Dis. 121, Suppl. S36–S43 (1970).Google Scholar
  163. Gangarosa, E. J., Donadio, J. A.: Surveillance of Foodborne Disease in the United States. A Comparison of Data — 1968–1969. J. infect. Dis. 122, 354–358 (1970).PubMedGoogle Scholar
  164. Gangarosa, E. J., Sanati, A., Saghari, H., Feeley, J. C: Multiple serotypes of vibrio cholerae isolated from a case of cholera. Evidence suggesting in vivo mutation. Lancet 1967I, 646–648.Google Scholar
  165. Genigeorgis, C, Sadler, W. W.: Effect of sodium chloride and pH on enterotoxin B production. J. Bact. 92, 1383–1387 (1966a).PubMedGoogle Scholar
  166. Genigeorgis, C, Sadler, W. W.: Characterization of strains of staphylococcus aureus isolated from livers of commercially slaughtered poultry. Poult. Sci. 45, 973–980 (1966b).PubMedGoogle Scholar
  167. Glew, R. H., Gorbach, S. L., Sack, R. B., Wallace, C. K.: Gut fluid loss produced by culture filtrates of E. coli isolated from the small bowel of patients with acute diarrhea. Clin. Res. 17, 368–369 (1969).Google Scholar
  168. Goldstein, P., Mandle, R. J., Wirts, C. W., Dammin, G. J.: Chronic “nonspecific” coliform diarrhea in Philadelphia. Gastroenterology 60, 669 (1971).Google Scholar
  169. Goldstein, P., Merril, T. G., Sprinz, H.: Experimental cholera: Morphological evidence of cytotoxicity. Arch. Path. 82, 54–59 (1966).PubMedGoogle Scholar
  170. Goodpasture, E. W.: Histopathology of intestine in cholera. Philipp. J. Sci. 22, 413–424 (1923).Google Scholar
  171. Gorbach, S. L.: Acute diarrhea—A “toxin” disease? New Engl. J. Med. 283, 44–45 (1970).PubMedGoogle Scholar
  172. Gorbach, S. L.: Intestinal microflora. Gastroenterology 60, 1110–1128, 1971.PubMedGoogle Scholar
  173. Gorbach, S. L.: Banwell, J. G., Chatterjee, B. D., Jacobs, B., Sack, R. B.: Acute undifferentiated diarrhea in the tropics. I. Alterations in intestinal microflora. J. clin. Invest. 50, 881–889 (1971).PubMedGoogle Scholar
  174. Gorbach, S. L.: Neale, G., Levitan, R., Hepner, G. W.: Alterations in human intestinal microflora during experimental diarrhea. Gut 11, 1–6 (1970).PubMedGoogle Scholar
  175. Gordon, R. S. Jr.: The failure of Asiatic cholera to give rise to “exudative enteropathy”. In: SEATO conference on cholera, Bangkok, p. 54 (1962).Google Scholar
  176. Gordon, R. S.: Intestinal secretory mechanisms in cholera. Symposium on cholera, Unzen, Nagasaki, National Institute of Health, Tokyo, p. 106 (1969).Google Scholar
  177. Grady, G. F., Chang, M. C.: Cholera enterotoxin free from permeability factor? J. infect. Dis. 121, Suppl. S92–S95 (1970).Google Scholar
  178. Graybill, J. R., Kaplan, M. M., Pierce, N. F.: Hormone-like effects of cholera exotoxin. Clin. Res. 18, 454 (1970).Google Scholar
  179. Grayer, D. T., Serebro, H.A., Iber, F. L., Hendrix, T. R.: Effect of cyclo-heximide on unidirectional sodium fluxes in the jejenum after cholera toxin exposure. Gastroenterology 58, 815–819 (1970).PubMedGoogle Scholar
  180. Greenough, W. B. III, Carpenter, C. C. J., Bayless, T. M., Hendrix, T. R.: The role of cholera exotoxin in the study of intestinal water and electrolyte transport. Progress in gastroenterology, vol. 2 (Jerzy Glass G. B., ed.), p. 236. New York: Grune & Stratton 1970b.Google Scholar
  181. Greenough, W. B. III, Pierce, N. F., Al-Awqati, Q., Carpenter, C. C. J.: Stimulation of gut electrolyte secretion by prostaglandins, theophylline and cholera exotoxin. J. clin. Invest. 48, 32a (1969).Google Scholar
  182. Greenough, W. B. III, Pierce, N. F., Vaughan, M.: Titration of cholera enterotoxin and antitoxin in isolated fat cells. J. infect. Dis. 121, S111-S113 (1970a).Google Scholar
  183. Gyles, C. L.: The response of ligated loops of pigs intestine to Escherichia coli. M. Sc. Thesis, University of Guelph, Canada (1966).Google Scholar
  184. Gyles, C. L.: Enterotoxicity of cell free Escherichia coli preparations in ligated segments of pig’s intestine. Ph. D. Thesis, University of Guelph, Canada (1968).Google Scholar
  185. Gyles, C. L.: Barnum, D. A.: A heat labile enterotoxin from Escherichia coli. Bact. Proc. p. 104 (1968).Google Scholar
  186. Gyles, C. L.: A heat labile enterotoxin from strains of Escherichia coli enteropathogenic for pigs. J. infect. Dis. 120, 419–426 (1969).PubMedGoogle Scholar
  187. Hakim, A. A., Lifson, N.: Effects of pressure on water and solute transport by dog intestinal mucosa in vitro. Amer. J. Physiol. 216, 276–284 (1969).PubMedGoogle Scholar
  188. Hall, H. E., Angelotti, R., Lewis, K. H.: Detection of the staphylococcal enterotoxins in food. Hlth Lab. Sci. 2, 179–191 (1965).Google Scholar
  189. Hallander, H. O.: Production of large quantities of enterotoxin B and other staphylococcal toxins on solid media. Acta. path, microbiol. scand. 63, 299–305 (1965).Google Scholar
  190. Hallander, H. O.: Bengtsson, S.: Studies on the cell toxicity and species specificity of purified staphylococcal toxins. Acta path, microbiol. scand. 70, 107–119 (1967).Google Scholar
  191. Hallander, H. O.: Körlof, B.: Enterotoxin producing staphylococci. Acta path, microbiol. scand. 71,359–375(1967).Google Scholar
  192. Harper, D. T., Grayer, D. I., Yardley, J. H., Hendrix, T. R.: Reversal of cholera exotoxin-induced jejunal secretion by cycloheximide. Johns Hopk. med. J. 126, 258–266 (1970).Google Scholar
  193. Hartman, P. E., Goodgal, S. H.: Bacterial Genetics (with particular reference to genetic transfer). Ann. Rev. Microbiol. 13, 465–504 (1959).Google Scholar
  194. Hauschild, A. H. W., Niilo, L., Dorward, W. J.: Experimental enteritis with food poisoning and classical strains of Clostridium Perfringens type A in lambs. J. Inf. Dis. 117, 379–386 (1967).Google Scholar
  195. Hauschild, A. H. W., Niilo, L., Dorward, W. J.: Clostridium Perfringens type A infection of ligated intestinal loops in lambs. Appl. Microbiol. 16, 1235–1239 (1968).PubMedGoogle Scholar
  196. Hauschild, A. H. W., Niilo, L., Dorward, W. J.: Enteropathogenic factors of food poisoning Clostridium Perfringens type A. Canad. J. Microbiol. 16, 331–338 (1970a).Google Scholar
  197. Hauschild, A. H. W., Niilo, L., Dorward, W. J.: Response of ligated intestinal loops in lambs to an enteropathogenic factor of Clostridium Perfringens type A. Canad. J. Microbiol. 16, 339–343 (1970b).Google Scholar
  198. Hauschild, A. H. W., Thatcher, F. S.: Experimental food poisoning with heat-susceptible Clostridium Perfringens type A. Canad. J. Microbiol. 14, 705–709 (1968).Google Scholar
  199. Hayama, T., Sugiyama, H.: Comparative resistance of vagotomized monkeys to IV Vs. Intragastric staphylococcal enterotoxin challenges. Proc. Soc. exp. Biol. (N.Y.) 115, 243–246 (1964).Google Scholar
  200. Heckly, R. J., Wolochow, H.: Characterization and purification of cholera toxin. J. infect. Dis. 121, Suppl. S80–S84 (1970).Google Scholar
  201. Hendrix, T. R., Banwell, J. G.: Pathogenesis of cholera. Gastroenterology 57, 751–755 (1969).PubMedGoogle Scholar
  202. Hendrix, T. R., Bayless, T. M.: Digestion: Intestinal secretion. Ann. Rev. Physiol. 32, 139–164 (1970).Google Scholar
  203. Hewlett, E. L., Greenough, W. B. III.: Purified cholera enterotoxin (CT) increases adenyl cyclase (ACY) and adenosine 3’5’ cyclic monophosphate (CYAMP) in fat cells. Clin. Res. 19, 459 (1971).Google Scholar
  204. Hirschhorn, N., Kinnie, J. L., Sachar, D. B., Northrup, R. S., Taylor, J. O., Ahmad, Z., Phillips, R. A.: Decrease in net stool output in cholera during intestinal perfusion with glucose containing solutions. New Engl. J. Med. 279, 176–181 (1968).PubMedGoogle Scholar
  205. Hobbs, B. C, Smith, M. E., Oakley, C. L., Warrack, G. H., Cruickshank, J. C: Clostridium Welchii Food Poisoning. J. Hyg. (Lond.) 51, 75–101 (1953).Google Scholar
  206. Huang, I. Y., Shih, T., Borja, C. R., Avena, R. M., Bergdoll, M.S.: Amino acid composition and terminal amino acids of staphylococcal enterotoxin C. Biochemistry (Wash.) 6, 1480–1484 (1967).Google Scholar
  207. Huber, G. S., Phillips, R. A.: Cholera and the sodium pump. SEATO Conference on Cholera, Dacca. E. Pakistan SEATO, Bangkok, Thailand, p. 37–40 (1962).Google Scholar
  208. Iber, F. L., McGonagle, T. J., Serebro, H. A., Luebbers, E. H., Bayless, T. M., Hendrix, T. R.: Unidirectional sodium flux in small intestine in experimental canine cholera. Amer. J. med. Sci. 258, 340–350 (1969).PubMedGoogle Scholar
  209. Jarvis, A. W., Lawrence, R. C.: Production of high titers of enterotoxins for the routine testing of staphylococci. Appl. Microbiol. 19, 698–699 (1970).PubMedGoogle Scholar
  210. June, R. C, Ferguson, W. W., Worfel, M. T.: Experiments in feeding adult volunteers with Escherichia coli 55, B5, a coliform organism associated with infant diarrhea. Amer. J. Hyg. 57, 222–236 (1953).PubMedGoogle Scholar
  211. Kao, V. C. Y., Sprinz, H.: Cholera toxin: Localization of immune response in ligated loops of rabbit ileum. Fed. Proc. 30, 572 (1971).Google Scholar
  212. Kao, V. C. Y., Sprinz, H.: Burrows, W.: Experimental cholera: Immunohistochemical observations on the localization of toxin in the intestinal mucosa. Gastroenterology 58, 965 (1970).Google Scholar
  213. Kasai, G. J., Burrows, W.: The titration of cholera toxin and antitoxin in the rabbit ileal loop. J. infect. Dis. 116, 606–614 (1966).PubMedGoogle Scholar
  214. Kasuma, H., Craig, J. P.: Production of biologically active substances by two strains of vibrio cholerae. Infec. Immun. 1, 80–87 (1970).Google Scholar
  215. Kato, E., Khan, M., Kujovich, L., Bergdoll, M. S.: Production of enterotoxin A. Appl. Microbiol. 14, 966–972 (1966).PubMedGoogle Scholar
  216. Kaur, J., Burrows, W., Cervavski, L.: Cholera toxins: Immunogenicity of the rabbit ileal loop toxin and related antigens. J. Bact. 100, 985–993 (1969).PubMedGoogle Scholar
  217. Kaur, J., Shrivastava, J. B.: Further studies on the KS preparation of vibrio polysaccharides. In: Proceedings of the Cholera Research Symposium. PHS Publication 1328, p. 248–253– Washington, D. C.: U.S. Government Printing Office 1965.Google Scholar
  218. Kent, T. H.: Staphylococcal enterotoxin gastroenteritis in rhesus monkeys. Amer. J. Path. 48, 387–407 (1966).PubMedGoogle Scholar
  219. Kent, T. H.: Jervis, H. R., Kuhns, J. G.: Enzyme histochemistry of acute staphylococcal enterotoxin gastroenteritis in rhesus monkeys. Amer. J. Path. 48, 667–681 (1966).PubMedGoogle Scholar
  220. Kenworthy, R.: Effect of Escherichia coli on germfree and gnotobiotic pigs. J. comp. Path. 80, 53–63 (1970).PubMedGoogle Scholar
  221. Keusch, G. T., Atthasampunna, P., Finkelstein, R. M.: A vascular permeability defect in experimental cholera. Proc. Soc. exp. Biol. (N.Y.) 124, 822–825 (1967).Google Scholar
  222. Keusch, G. T., Mata, L. J., Grady, G. F.: Shigella enterotoxin: Isolation and Characterizasion. Clin. Res. 18, 442 (1970).Google Scholar
  223. Kimberg, D. V., Field, M., Johnson, J., Henderson, A., Gershon, E.: Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. J. clin. Invest. 50, 1218–1230 (1971).PubMedGoogle Scholar
  224. Kirby, A. C, Hall, E. G., Coackley, W.: Neonatal diarrhea and vomiting outbreaks in the same maternity unit. Lancet 1950II, 201–207.Google Scholar
  225. Koch, R.: In: Die Konferenz zur Erörterung der Cholerafrage. Dtsch. med. Wschr. 10, 499 (1884).Google Scholar
  226. Koch, R.: Über den augenblicklichen Stand der bakteriologischen Choleradiagnose. Z. Hyg. Infect.-Kr. (Lpz.) 14, 319–338 (1893).Google Scholar
  227. Kohler, E. M.: Studies of Escherichia coli in gnotobiotic pigs. IV. Comparison of enteropathogenic and nonenteropathogenic strains. Canad. J. comp. Med. 31, 277–282 (1967).PubMedGoogle Scholar
  228. Kohler, E. M.: Enterotoxic activity of filtrates of Escherichia coli in young pigs. Amer. J. vet. Res. 29, 2263–2274 (1968).PubMedGoogle Scholar
  229. Kohler, E. M.: Observations on enterotoxins produced by enteropathogenic Escherichia coli. Ann. N.Y. Acad. Sci. 176, 212–219 (1971).Google Scholar
  230. Kohler, E. M.: Bohl, E.H.: Studies of Escherichia coli in gnotobiotic pigs. I. Experimental reproduction of colibacillosis. Canad. J. comp. Med. 30, 199–203 (1966a).PubMedGoogle Scholar
  231. Kohler, E. M.: Bohl, E.H.: Studies of Escherichia coli in gnotobiotic pigs. III. Evaluation of orally administered specific antisera. Canad. J. comp. Med. 30, 233–237 (1966b).PubMedGoogle Scholar
  232. Kohler, E. M.: Cross, R. F: Studies of Escherichia coli in gnotobiotic pigs. VI. Effects of feeding bacteria-free filtrates of broth cultures. Canad. J. comp. Med. 33, 173–177 (1969).Google Scholar
  233. Koya, G., Kosakai, N., Fukasawa, Y.: Supplementary studies on the multiplications of Escherichia coli 0–111 B4 in the intestinal tract of adult volunteers and its relations to manifestation of coli enteritis. Jap. J. med. Sci. Biol. 7,655–659(1954).PubMedGoogle Scholar
  234. Kraft, A. R., Tompkins, R. K., Zollinger, R. M.: Recognition and management of the diarrheal syndrome caused by nonbeta islet cell tumors of the pancreas. Amer. J. Surg. 119, 163–170 (1970).PubMedGoogle Scholar
  235. Kubota, Y., Liu, P. V.: An Enterotoxin of Pseudomonas Aeruginosa. J. infect. Dis. 123, 97–98 (1971).PubMedGoogle Scholar
  236. Kuhr, J., Burrows, W.: Immunity to cholera: Relation of fraction II of type 2 cholera toxin to vibriocidal antibody. J. Bact. 98, 467–474 (1969).Google Scholar
  237. Kuru, M., Sugihara, S.: Contributions to the knowledge of bulbar autonomic centres. II. Relationship of the vagal nuclei to the gastrojejunal motility. Appendix: On the vomiting centre. Jap. J. Physiol. 5, 21–36 (1955).Google Scholar
  238. Labrec, E. H., Formal, S. B.: Experimental shigella infections. IV. Fluorescent antibody studies of an infection in guinea pigs. J. Immunol. 87, 562–572 (1961).PubMedGoogle Scholar
  239. Labrec, E. H., Schneider, H., Magnani, T. J., Formal, S. B.: Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J. Bact. 88, 1503–1518 (1964).PubMedGoogle Scholar
  240. Lanyi, B., Szita, J., Ringelhann, B., Kovach, K.: A water borne outbreak of enteritis associated with Escherichia coli serotype 124:72:32. Acta microbiol. Acad. Sci. hung. 6, 77–84 (1959).Google Scholar
  241. Larson, C. L., Ribi, E., Milner, K. C, Liberman, J. E.: A method for titrating endotoxic activity in the skin of rabbits. J. exp. Med. 111, 1–20 (1960).PubMedGoogle Scholar
  242. Leitch, G. J., Burrows, W.: Experimental cholera in the rabbit ligated intestine: Ion and water accumulation in the duodenum, ileum and colon. J. infect. Dis. 118, 349–359 (1968).PubMedGoogle Scholar
  243. Leitch, G. J., Burrows, W.: Stolle, L. C.: Experimental cholera in the rabbit intestinal loop: Fluid accumulation and sodium pump inhibition. J. infect. Dis. 117, 197–202 (1967).PubMedGoogle Scholar
  244. Levine, M. M., Dupont, H. L., Formal, S. B., Libonati, J. P., Gangarosa, E. J., Snyder, M. J., Hornick, R. B.: An immunologic approach to the control of epidemic shiga dysentery. Clin. Res. 19, 461 (1971).Google Scholar
  245. Lewis, A. C, Freeman, B. A.: Separation of type 2 toxins of vibrio cholerae. Science 165, 808–809 (1969).PubMedGoogle Scholar
  246. Ling, G. N.: Thoughts on the molecular mechanism of the normal intestinal mucosa as a barrier to sodium ion movement and massive fluid loss in cholera. Proc. of the Cholera Research Symposium, Honolulu, 103–106 (1965).Google Scholar
  247. LoSpalluto, J., Finkelstein, R. A.: Chemical and physical properties of choleragen and choleragenoid. Fed. Proc. 30, 304 (1971).Google Scholar
  248. Love, A. H. G.: Water and sodium absorption by the intestine in cholera. Gut 10, 63–67 (1969).PubMedGoogle Scholar
  249. Love, A. H. G.: Rohde, J. E., Veall, N.: Studies on bidirectional sodium fluxes across the int estinal mucosa in cholera patients. Gut 11, 1056–1057 (1970).PubMedGoogle Scholar
  250. Macchia, V., Bates, R. W., Pastan, I.: The Purification and Properties of a Thyroid-Stimulating Factor Isolated from Clostridium Perfringens. J. biol. Chem. 242, 3726–3730 (1967).PubMedGoogle Scholar
  251. Markus, Z.: Enterotoxin B synthesis by staphylococcus aureus S-6. Bact. Proc. p. 81 (1969).Google Scholar
  252. Markus, Z.: Silverman, G. J.: Enterotoxin B. Production by nongrowing cells of staphylococcus aureus. J. Bact. 96, 1446–1447 (1968).PubMedGoogle Scholar
  253. Markus, Z.: Silverman, G. J.: Enterotoxin B. Synthesis by replicating and non-replicating cells of staphylococcus aureus. J. Bact. 97, 506–512 (1969).PubMedGoogle Scholar
  254. Martin, W. J., Marcus, S.: Relation of pyrogenic and emetic properties of enterobacteriaceal endotoxin and of staphylococcal enterotoxin. J. Bact. 87, 1019–1026 (1964).PubMedGoogle Scholar
  255. McCartney, J. E., Olitsky, P. K.: Separation of the toxins of bacillus dysenteriae shiga. J. exp. Med. 37, 767–779 (1923).PubMedGoogle Scholar
  256. McLean, R. A., Lilly, H. D., Alford, J. A.: Effects of meat curing salts and temperature on production of staphylococcal enterotoxin B. J. Bact. 95,1207–1211 (1968).PubMedGoogle Scholar
  257. McNaught, W., Roberts, G. B. S: Enteropathogenic effects of strains of bacterium coli isolated from cases of gastroenteritis. J. Path. Bact. 76, 115–158 (1958).Google Scholar
  258. Merrill, T. G., Sprinz, H.: Ultrastructural changes of intestinal capillaries in cholera. Fed. Proc. 25, 456 (1966).Google Scholar
  259. Merrill, T. G., Sprinz, H.: The effect of staphylococcal enterotoxin on the fine structure of the monkey jejunum. Lab. Invest. 18, 114–123 (1968).PubMedGoogle Scholar
  260. Metchnikoff, E.: Recherches sur le cholera et les vibrions. Ann Inst. Pasteur 8, 529–589 (1894).Google Scholar
  261. Moon, H. W., Sorensen, D. K., Sautter, J. H.: Escherichia coli infection of the ligated intestinal loop of the newborn pig. Amer. J. vet. Res. 27, 1317–1325 (1966).Google Scholar
  262. Moon, H. W., Whipp, S. C.: Systems for testing the enteropathogenicity of Escherichia coli. Ann. N.Y. Acad. Sci. 176, 197–211 (1971).Google Scholar
  263. Moon, H. W., Whipp, S. C.: Baetz, A. L.: Response of the intestinal mucosa of pigs and rabbits to Escherichia coli enterotoxin: A histologic and ultrastructural study. Unpublished observations cited by Moon and Whipp (1971).Google Scholar
  264. Moon, H. W., Whipp, S. C.: Engstrom, G. W., Baetz, A. L.: Response of the rabbit ileal loop to cell free products from Escherichia coli enteropathogenic for swine. J. infect. Dis. 121, 182–187 (1970).PubMedGoogle Scholar
  265. Moritz, M., Iber, F. L., Moore, E. W.: Rabbit cholera: Effects of cycloheximide on net water and ion fluxes and transmural electric potentials. Gastroenterology 60, 789 (1971).Google Scholar
  266. Morris, E. L., Hodoval, L. F., Beisel, W. R.: The unusual role of the kidney during intoxication of monkeys by intravenous staphylococcal enterotoxin B. J. infect. Dis. 117, 273–284 (1967).PubMedGoogle Scholar
  267. Morse, S. A., Mah, R. A., Dobrogosz, W. J.: Regulation of staphylococcal enterotoxin B. J. Bact. 98, 4–9 (1969).PubMedGoogle Scholar
  268. Mosley, W. E. H., Aziz, K. M. S., Ahmed, A.: Serological evidence for the identity of the vascular permeability factor and ileal loop toxin of vibrio cholerae. J. infect. Dis. 121, 243–250 (1970a).PubMedGoogle Scholar
  269. Mosley, W. E. H., Benenson, A. S., Barui, R.: A serological survery for cholera antibodies in rural East Pakistan, l. The distribution of antibody in the control population of a cholera vaccine field trial area and the relation of antibody titre to the pattern of endemic cholera. Bull. Wld Hlth Org. 38, 327–334 (1968a).Google Scholar
  270. Mosley, W. E. H., Benenson, A. S., Barui, R.: A serological survey for cholera antibodies in rural East Pakistan. 2. A comparison of antibody titres in the immunized and control populations of a cholera vaccine field trial area and the relation of antibody titre to cholera case rate. Bull. Wld Hlth Org. 38, 335–346 (1968b).Google Scholar
  271. Mosley, W. E. H., Woodward, W. E., Aziz, K. M. A., Mizanur Rahman, A. S. M., Alauddin Chowdhury, A. K. M., Ahmed, A., Feeley, J. C.: The 1968–1969 cholera vaccine field trial in rural East Pakistan. Effectivness of monovalent Ogawa and Inaba vaccines and a purified Inaba antigen with comparative results of serological and animal protection tests. J. infect. Dis. 121 Suppl. S1–S9 (1970b).Google Scholar
  272. Nakanishi, R., Suchi, H., Tajiri, L, Yamasato, M.: An enteropathogenic Escherichia coli isolated from patients with ekiri. J. Japan Ass. Infect. Dis. 31, 169–174 (1956).Google Scholar
  273. Neter, E.: Enteritis due to enteropathogenic Escherichia coli. Present day status and unsolved problems. J. Pediat. 55, 222–239 (1959).Google Scholar
  274. Nielsen, N. O., Sautter, J. H.: Infection of ligated intestinal loops with hemolytic Escherichia coli in the pig. Canad. vet. J. 9, 90–97 (1968).Google Scholar
  275. Normann, S. J., Jaeger, R. F., Johnsey, R. T.: Pathology of experimental entero-toxemia. The in vivo localization of staphylococcal enterotoxin B. Lab. Invest. 20, 17–25 (1969).PubMedGoogle Scholar
  276. Norris, H. T., Curran, P. F., Schultz, S. G.: Modification of intestinal secretion in experimental cholera. J. infect. Dis. 119, 117–125 (1969).PubMedGoogle Scholar
  277. Norris, H. T., Finkelstein, R. A., Dutta, N. K., Sprinz, H.: Intestinal manifestations of cholera in infant rabbits. A morphologic study. Lab. Invest. 14, 1428–1436 (1965).PubMedGoogle Scholar
  278. Norris, H. T., Majno, G.: On the role of ileal epithelium in the pathogenesis of experimental cholera. Amer. J. Path. 53, 263–279 (1968).PubMedGoogle Scholar
  279. Norris, H. T., Sumner, D. S.: Preliminary observations on mucosal blood flow in experimental cholera. Fed. Proc. 30, 544 (1971).Google Scholar
  280. Northrup, R. S., Bienenstock, J., Tomasi, T. B., Jr.: Immunoglobulins and antibody activity in the intestine and serum in cholera. I. Analysis of immunoglobulins in cholera stool. J. infect. Dis. 121, Suppl. S137–S141 (1970).Google Scholar
  281. Northrup, R. S., Hossain, S. A.: Immunoglobulins and antibody activity in the intestine and serum in cholera. II. Measurement of antibody activity in jejunal aspirates and sera of cholera patients by radioimmunidiffusion. J. infect. Dis. 121, Suppl. S142–S146(1970).Google Scholar
  282. Nygren, B.: Phospholipase C-Producing Bacteria and Food Poisoning. Acta path, microbiol. scand. (Suppl.) 160, 1–88 (1962).Google Scholar
  283. Ogawa, H., Nakamura, A., Sakazaki, R.: Pathogenic properties of “enteropathogenic” Escherichia coli from diarrheal children and adults. Jap. J. med. Sci. Biol. 21, 333–349 (1968).PubMedGoogle Scholar
  284. Olitsky, P. K., Kliger, I. J.: Toxins and antitoxins of bacillus dysenteriae shiga. J. exp. Med. 31, 19–33 (1920).PubMedGoogle Scholar
  285. Omori, G., Kato, Y.: A staphylococcal food poisoning caused by a coagulase negative strain. Biken’s J. 2, 92 (1959) (cited by Breckenridge and Bergdoll, 1971).Google Scholar
  286. Oseasohn, R. O., Benenson, A. S., Fahimuddin, M.: Field trial of cholera vaccine in rural East Pakistan. Lancet 1965I, 450–452.Google Scholar
  287. Oza, N. B., Dutta, N. K.: Experimental cholera produced by toxin prepared by ultrasonic disintegration of vibrio comma. J. Bact. 85, 497–498 (1963).PubMedGoogle Scholar
  288. Palmer, E. D.: The morphologic consequences of acute exogenous (staphylococcic) gastroenteritis on the gastric mucosa. Gastroenterology 19, 462–475 (1951).PubMedGoogle Scholar
  289. Panse, M. V., Dutta, N. K.: Excretion of toxin with stools of cholera patients. J. infect. Dis. 109, 81–84 (1961).PubMedGoogle Scholar
  290. Patnaik, B. K., Ghosh, H. K.: Histopathological studies on experimental cholera. Brit. J. exp. Path. 47, 210–214 (1966).Google Scholar
  291. Pfeiffer, R.: Untersuchungen über das Choleragift. Z. Hyg. Infect-Kr. 11, 393–412 (1892).Google Scholar
  292. Pierce, N. F., Banwell, J. G., Gorbach, S. L., Mitra, R. C, Mondal, A.: Convalescent carriers of vibrio cholerae. Ann. intern. Med. 72, 357–364 (1970b).PubMedGoogle Scholar
  293. Pierce, N. F., Banwell, J. G., Mitra, R. D., Caranasos, G. J., Keimowitz, R. L, Mondal, A., Manji, P. M.: Effect of intragastric glucose-electrolyte infusion upon water and electrolyte balance in Asiatic cholera. Gastroenterology 55, 333–343 (1968).PubMedGoogle Scholar
  294. Pierce, N. F., Banwell, J. G., Sack, R. B., Mitra, R. C, Mondal, A.: Magnitude and duration of antitoxic response to human infection with vibrio cholerae. J. infect. Dis. 121, Suppl. S31-S35 (1970a).Google Scholar
  295. Pierce, N. F., Carpenter, C. C. J., Elliott, H. L., Greenough, W. B. III.: Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum. Gastroenterology 60, 22–32 (1971b).PubMedGoogle Scholar
  296. Pierce, N. F., Greenough, W. B., Carpenter, C. C. J.: Vibrio cholerae enterotoxin and its mode of action. Bact. Rev. 35, 1–13 (1971a).PubMedGoogle Scholar
  297. Pierce, N.F., Hennessey, K.N., Sack, G. H., Jr., Mitra, R. C: Gastric acidity in cholera. Clin. Res. 19, 400 (1971c).Google Scholar
  298. Pierce, N.F., Sack, R. B., Mitra, R. C, Banwell, J. G., Brigham, K. L., Fedson, D. S., Mondal, A.: Replacement of water and electrolyte losses in cholera by an oral glucose-electrolyte solution. Ann. intern. Med. 70, 1173–1181 (1969).PubMedGoogle Scholar
  299. Prohaska, J. V.: Role of staphylococcal enterotoxin in the induction of experimental ileitis. Ann. Surg. 158, 492–497 (1963).Google Scholar
  300. Prohaska, J. V.: Development and fate of experimentally induced enteritis. Gastroenterology 51, 913–925 (1966).PubMedGoogle Scholar
  301. Prohaska, J. V.: Jacobson, M. J., Drake, CT., Tan, T.: Staphylococcus enterotoxin enteritis. Surg. Gynec. Obstet. 109, 73–77 (1959).PubMedGoogle Scholar
  302. Prohaska, J. V.: Long, E. T., Nelson, T. S.: Pseudomembranous enterocolitis; its etiology and mechanism of the disease process. Arch. Surg. 72, 977–983 (1956).Google Scholar
  303. Raj, H. D., Bergdoll, M. S.: Effect of enterotoxin B on human volunteers. J. Bact. 98, 833–834 (1969).PubMedGoogle Scholar
  304. Reiser, R. F., Weiss, K. F.: Production of staphylococcal enterotoxins A, B, and C in various media. Appl. Microbiol. 18, 1041–1043 (1969).PubMedGoogle Scholar
  305. Rhoda, D. A., Elsberry, D. D., Beisel, W. R.: Fluid compartment alterations in the monkey with staphylococcic B enterotoxemia. Amer. J. vet. Res. 31, 507–514 (1970).PubMedGoogle Scholar
  306. Rosen, O. M., Rosen, S. M.: A bacterial activator of frog erythrocyte adenyl cyclase. Arch. Biochem. 141, 346–352 (1970).PubMedGoogle Scholar
  307. Rosenwald, A. J., Lincoln, R. E.: Streptomycin inhibition of elaboration of staphylococcal enterotoxic protein. J. Bact. 92, 279–280 (1966).PubMedGoogle Scholar
  308. Rosner, R.: Antepartum culture findings of mothers in relation to infantile diarrhea. Amer. J. clin. Path. 45, 732–736 (1966).Google Scholar
  309. Rowe, B., Taylor, J., Bettelheim, K. A.: An investigation of traveller’s diarrhea. Lancet 1970I, 1–5.Google Scholar
  310. Richardson, S. H.: Inhibition of intestinal ion translocase enzymes by culture filtrates of vibrio cholerae. J. Bact. 91, 1384–1386 (1966).PubMedGoogle Scholar
  311. Richardson, S. H.: Factors influencing in vitro skin permeability factor production by vibrio cholerae. J. Bact. 100, 27–34 (1969).PubMedGoogle Scholar
  312. Richardson, S. H.: Evans, D. J., Jr.: Isolation of cholera toxins by dextran sulfate precipitation. J. Bact. 96, 1443–1445 (1968).PubMedGoogle Scholar
  313. Richardson, S. H.: Noftle, K. A.: Purification and properties of permeability factor/cholera enterotoxin from complex and synthetic media. J. infect. Dis. 121, Suppl. S73–S79 (1970).Google Scholar
  314. Sack, R. B., Carpenter, C. C. J.: Experimental canine cholera. I. Development of the model. J. infect. Dis. 119, 138–149 (1969).PubMedGoogle Scholar
  315. Sack, R. B., Gorbach, S., Banwell, J. G., Jacobs, B., Chatterjee, B. D.: Enterotoxigenic Escherichia coli isolated from patients with severe cholera-like disease. J. infect. Dis. 123, 378–385 (1971).PubMedGoogle Scholar
  316. Sakazaki, R., Namioka, S.: Studies on a new Escherichia coli type. O l36:K78 (B22). Jap. J. exp. Med. 27, 29–36 (1957).Google Scholar
  317. Sakazaki, R., Tamura, K., Saito, M.: Enteropathogenic Escherichia coli associated with diarrhea in children and adults. Jap. J. med. Sci. Biol. 20, 387–399 (1967).PubMedGoogle Scholar
  318. Salomon, L. L., Tew, R. W.: Assay of staphylococcal enterotoxin B by latex agglutination. Proc. Soc. exp. Biol. (N.Y.) 129, 539–542 (1968).Google Scholar
  319. Schaeffer, W. I., Gablicks, J., Calitis, R.: Interaction of staphylococcal enterotoxin B with cell cultures of human intestine. J. Bact. 91, 21–26 (1966).PubMedGoogle Scholar
  320. Schaeffer, W. I., Gablicks, J., Calitis, R.: Interference by trypsin in the interaction of staphylococcal enterotoxin B and cell cultures of human embryonic intestine. J. Bact. 93, 1489–1492 (1967).PubMedGoogle Scholar
  321. Schafer, D. E., Bannerjee, D., Bhargava, U., Sengupta, S., Sircar, B., Thakur, A. K.: Rabbit small-bowel response to cell free filtrate of choleraic fluid. Proc. Soc. exp. Biol. (N.Y.) 134, 90–94 (1970a).Google Scholar
  322. Schafer, D. E., Lust, W. D., Sircar, B., Goldberg, M. D.: Elevated concentration of adenosine 3’, 5’ cyclic monophosphate concentration in intestinal mucosa after treatment with cholera toxin. Proc. nat. Acad. Sci. (Wash.) 67, 851–856 (1970b).Google Scholar
  323. Schantz, E. J., Roessler, W. G., Wagman, J., Spero, L., Dunnery, D. A., Bergdoll, M. S.: Purification of staphylococcal enterotoxin B. Biochemistry 4,1011–1016 (1965).PubMedGoogle Scholar
  324. Schroeder, S. A., Caldwell, J. R., Vernon, T. M., White, P. C, Granger, S. I., Bennett, J. V.: A waterborne outbreak of gastroenteritis in adults associated with Escherichia coli. Lancet 1968I, 737–740.Google Scholar
  325. Segalove, M.: Effect of penicillin on growth and toxin production by enterotoxic staphylococci. J. infect. Dis. 81, 228–242 (1947).PubMedGoogle Scholar
  326. Serebro, H. A., Bayless, T. M., Hendrix, T. R., Iber, F. L., McGonagle, T. M.: Absorption of d-glucose by the rabbit jejunum during cholera toxin-induced diarrhoea. Nature (Lond.) 217, 1272–1273 (1968b).Google Scholar
  327. Serebro, H. A., Iber, F. L., Yardley, J. H., Hendrix, T. R.: Inhibition of cholera toxin action in the rabbit by cycloheximide. Gastroenterology 56, 506–511 (1969).PubMedGoogle Scholar
  328. Serebro, H. A., McGonagle, T. J., Iber, F. L., Royall, R., Hendrix, T. R.: An effect of cholera toxin on small intestine without direct mucosal contact. Johns Hopkins Med. J. 123, 229–232 (1968a).PubMedGoogle Scholar
  329. Sereney, B.: Experimental shigella kerato-conjuctivitis. A preliminary report. Acta microbiol. Acad. Sci. hung. 2, 293–296 (1955).Google Scholar
  330. Sharp, G. W. G., Hynie, S.: Stimulation of intestinal adenyl cyclase by cholera toxin. Nature (Lond.) 229, 266–269 (1971).Google Scholar
  331. Sheahan, D. G., Jervis, H. R., Takeuchi, A., Sprinz, H.: The effect of staphylococcal enterotoxin on the epithelial mucosubstances of the small intestine of rhesus monkeys. Amer. J. Path. 60, 1–18 (1970).PubMedGoogle Scholar
  332. Sheahan, D. G., Sprinz, H.: Cholera toxin: Response to intestinal intramural inoculation. Gastroenterology 60, 716 (1971).Google Scholar
  333. Shemano, I., Hitchens, J. T., Beiler, J. M.: Paradoxical inhibitory effects of staphylococcal enterotoxin. Gastroenterology 53, 71–77 (1967).Google Scholar
  334. Sherr, H. P., Banwell, J. G., Hendrix, T. R.: Pathophysiological characteristics of E. coli enterotoxin: A comparison with cholera exotoxin. Clin. Res. 19, 403 (1971).Google Scholar
  335. Silverman, S. J., Espeseth, D. A., Schantz, E. J.: Effect of formaldehyde on the immunochemical and biological activity of staphylococcal enterotoxin B. J. Bact. 98, 437–442 (1969b).PubMedGoogle Scholar
  336. Silverman, S. J., Knott, A. R., Howard, M.: Rapid sensitive assay for staphylococcal enterotoxin and a comparison of serological methods. Appl. Microbiol. 16, 1019–1023 (1968).PubMedGoogle Scholar
  337. Silverman, S. J., Moore, G. T., Roessler, W. G.: Effect of formaldehyde on the immunogemcity of staphylococcal enterotoxin B for macaca mulatto,. J. Bact. 98, 443–446 (1969a).PubMedGoogle Scholar
  338. Silverman, S. J., Schantz, E. J., Espeseth, D. A., Roessler, W. G.: Effect of formalin on the immunochemical and biological activity of staphylococcal enteroxin. Bact. Proc. p. 43 (1966).Google Scholar
  339. Smith, D. H.: Salmonella with transferable drug resistance. New Engl. J. Med. 275, 625–630 (1966).PubMedGoogle Scholar
  340. Smith, D. H.: Armour, S. E.: Transferable R factors in enteric bacteria causing infections of the genitourinary tract. Lancet 1966II, 15–18.Google Scholar
  341. Smith, H. W.: Observations on the aetiology of neonatal diarrhea (Scours) in calves. J. Path. Bact. 84, 147–168 (1962).PubMedGoogle Scholar
  342. Smith, H. W.: Gyles, C. L.: Escherichia coli enterotoxin. Vet. Rec. 85, 694 (1969).PubMedGoogle Scholar
  343. Smith, H.W., Gyles, C. L.: The relationship between two apparently different enterotoxins produced by enteropathogenic strains of Escherichia coli of porcine origin. J. Med. Microbiol. 3, 387–402 (1970a).PubMedGoogle Scholar
  344. Smith, H.W., Gyles, C. L.: The effect of cell free fluids prepared from cultures of human and animal enteropathogenic strains of Escherichia coli on ligated intestinal segments of rabbits and pigs. J. Med. Microbiol. 3, 403–409 (1970b).PubMedGoogle Scholar
  345. Smith, H.W., Halls, S.: Observations by the ligated intestinal segment and oral inoculation methods on Escherichia coli infections in pigs, calves, lambs and rabbits. J. Path. Bact. 93, 499–529 (1967 a).PubMedGoogle Scholar
  346. Smith, H.W., Halls, S.: Studies on Escherichia coli enterotoxin. J. Path. Bact. 93, 531–543 (1967b).PubMedGoogle Scholar
  347. Smith, H.W., Halls, S.: The transmissable nature of the genetic factor in Escherichia coli that controls enterotoxin production. J. gen. Microbiol. 52, 319–334 (1968).Google Scholar
  348. Smith, H.W., Jones, J. E. T.: Observations on the alimentary tract and its bacterial flora in healthy and diseased pigs. J. Path. Bact. 86, 387–412 (1963).PubMedGoogle Scholar
  349. Spero, L., Stefanye, D., Brecher, P. I., Jacoby, H. M., Dalidowicz, J. E., Schantz, E. J.: Amino acid composition and terminal amino acids of staphylococcal enterotoxin B. Biochemistry 4, 1024–1030 (1965).PubMedGoogle Scholar
  350. Sprinz, H.: Morphological response of intestinal mucosa to enteric bacteria and its implication for sprue and Asiatic cholera. Fed. Proc. 21, 57–64 (1962).Google Scholar
  351. Sprinz, H.: Pathogenesis of intestinal infections. Arch. Path. 87, 556–562 (1969).PubMedGoogle Scholar
  352. Sprinz, H.: Factors influencing intestinal cell renewal. A statement of principles. Cancer (Philad.) 28, 71–74 (1971).Google Scholar
  353. Sprinz, H.: Sribhibhadh, R., Gangarosa, E. J., Benyajati, C, Kundel, D., Halstead, S.: Biopsy of small bowel of Thai people. With special reference to recovery from Asiatic cholera and to an intestinal malabsorption syndrome. Amer. J. clin. Path. 38,43–51 (1962).Google Scholar
  354. Spyrides, G. J., Feeley, J. C.: Concentration and purification of cholera exotoxin by absorption on aluminum compound gels. J. infect. Dis. 121, Suppl. S96–S99 (1970).Google Scholar
  355. Staab, E. V., Niederhuber, J., Rhoda, D. A., Faulkner, C. S. II, Beisel, W. R.: Role of the kidney in staphylococcal enterotoxemia. Appl. Microbiol. 17, 394–398 (1969).PubMedGoogle Scholar
  356. Staley, T. E., Jones, E. W., Corley, L. D.: Intestinal monocontamination in the neonatal pig: Microbiological and microscopic studies in Germfree biology: Experimental and clinical aspects, ed. by E. A. Mirand and N. Back, p. 65–73-New York: Plenum Press 1969a.Google Scholar
  357. Staley, T. E., Jones, E. W., Corley, L. D.: Attachment and penetretation of Escherichia coli into intestinal epithelium of the ileum in newborn pigs. Amer. J. Path. 56, 371–392 (1969b).PubMedGoogle Scholar
  358. Staley, T. E., Jones, E. W., Corley, L. D.: Anderson, I. L.: Intestinal permeability of Escherichia coli in the foal. Amer. J. vet. Res. 31, 1481–1483 (1970).PubMedGoogle Scholar
  359. Stark, R. L., Middaugh, P. R.: Immunofluorescent detection of enterotoxin B in food and a culture medium. Appl. Microbiol. 18, 631-635 (1969).PubMedGoogle Scholar
  360. Stevens, A. J.: Coliform enteritis in the young pig and a practical approach to the control of enteritis. Vet. Res. 75, 1241–1246 (1963).Google Scholar
  361. Stoerk, O.: Über Cholera. Beitr. path. Anat. 62, 121–174 (1916).Google Scholar
  362. Strasters, K. C, Winkler, K. C: Carbohydrate metabolism of staphylococcus aureus. J. gen. Microbiol. 33, 218–229 (1963).Google Scholar
  363. Strombeck, D. R.: In vivo and in vitro studies of intestinal fluid production by cholera toxin in the rat. Gastroenterology 60, 804 (1971).Google Scholar
  364. Stulc, J.: The influence of exotoxin shigella shigae on the blood brain barrier permeability to inorganic phosphate. Life Sci. 5, 1801–1808 (1966).PubMedGoogle Scholar
  365. Sugiyama, H.: Endotoxin-like responses induced by staphylococcal enterotoxin. J. infect. Dis. 116, 162–170 (1966).PubMedGoogle Scholar
  366. Sugiyama, H., Bergdoll, M.S., Dack, G. M.: Staphylococcal enterotoxin: increased vomiting incidence in monkeys following subemetic doses of dihydro-ergotamine. Proc. Soc. exp. Biol. (N.Y.) 97, 900–903 (1958).Google Scholar
  367. Sugiyama, H., Chow, K. L., Dragstedt, L. R. IL: Study of emetic receptor sites for staphylococcal enterotoxin in monkeys. Proc. Soc. exp. Biol. (N.Y.) 108, 92–95 (1961).Google Scholar
  368. Sugiyama, H., Hayama, T.: Comparative resistance of vagotomised monkeys to intravenous vs. intragastric staphylococcal enterotoxin challenges. Proc. Soc. exp. Biol. (N.Y.) 115, 243–246 (1964).Google Scholar
  369. Sugiyama, H., Hayama, T.: Abdominal viscera as site of emetic action for staphylococcal enterotoxin in the monkey. J. infect. Dis. 115, 330-336 (1965).PubMedGoogle Scholar
  370. Sugiyama, H., McKissic, E. M., Jr.: Leukocytic response in monkeys challenged with staphylococcal enterotoxin. J. Bact. 92, 349–352 (1966).PubMedGoogle Scholar
  371. Sullivan, R.: Effects of enterotoxin B on intestinal transport in vitro. Proc. Soc. exp. Biol. (N.Y.) 131, 1159–1162 (1969).Google Scholar
  372. Surgalla, M. J., Bergdoll, M. S., Dack, G. M.: Some observations on assay of staphylococcal enterotoxin by monkey-feeding test. J. Lab. clin. Med. 41, 782–788 (1953).PubMedGoogle Scholar
  373. Surgalla, M. J., Bergdoll, M. S., Dack, G. M.: Staphylococcal enterotoxin: neutralization by rabbit antiserum. J. Immunol. 72, 398–403 (1954).PubMedGoogle Scholar
  374. Surgalla, M. J., Dack, G. M.: Enterotoxin produced by micrococci from cases of enteritis after antibiotic therapy. J. Amer. med. Ass. 158, 649–650 (1955).Google Scholar
  375. Surgalla, M. J., Kadavy, J. L., Bergdoll, M.S., Dack, G. M.: Staphylococcal enterotoxin: production methods. J. infect. Dis. 89, 180–184 (1951).PubMedGoogle Scholar
  376. Sussman, M., Ryan, C, Shields, R.: Effects of staphylococcal enterotoxin upon the intestinal handling of water and electrolytes. Brit. J. Surg. 57, 391 (1970).PubMedGoogle Scholar
  377. Takeuchi, A., Formal, S. B., Sprinz, H.: Experimental acute colitis in the rhesus monkey following peroral infection with shigella flexneri. Amer. J. Path. 52, 503–529 (1968).PubMedGoogle Scholar
  378. Takeuchi, A., Sprinz, H., Labrec, E. H., Formal, S. B.: Experimental bacillary dysentery. An electron microscopic study of the response of the intestinal mucosa to bacterial invasion. Amer. J. Path. 47, 1011–1044 (1965).PubMedGoogle Scholar
  379. Tan, T. L., Drake, C. T., Jacobson, M. J., Prohaska, J. V: The experimental development of pseudomembranous enterocolitis. Surg. Gynec. Obstet. 108, 415–420(1959).PubMedGoogle Scholar
  380. Taylor, J.: Host specificity and enteropathogenicity of Escherichia coli. J. appl. Bact. 24, 316–325 (1961).Google Scholar
  381. Taylor, J.: Host parasite relations of Escherichia coli in man. J. appl. Bact. 29, 1–12 (1966).Google Scholar
  382. Taylor, J.: Bettelheim, K. A.: The action of chloroform-killed suspensions of enteropatho-genic Escherichia coli on ligated rabbit gut segments. J. gen. Microbiol. 42, 309–313 (1966).PubMedGoogle Scholar
  383. Taylor, J.: Maltby, M. P., Payne, J. M.: Factors influencing the response of ligated abbitgut segments to injected Escherichia coli. J. Path. Bact. 76, 491–499 (1958).PubMedGoogle Scholar
  384. Taylor, J.: Wilkins, M. P.: The effect of salmonella and shigella on ligated loops of rabbit gut. Indian J. med. Res. 49, 544–549 (1961).Google Scholar
  385. Taylor, J.: Wilkins, M. P.: Payne, J. M.: Relation of rabbit gut reaction to enteropathogenic Escherichia coli. Brit. J. exp. Path. 42, 43–52 (1961).PubMedGoogle Scholar
  386. Thatcher, F. S., Simon, W.: A comparative appraisal of the properties of “staphylococci” isolated from clinical sites and from dairy products. Canad. J. Microbiol. 2, 703–714 (1956).Google Scholar
  387. Thomlinson, J. R.: Symposium: Enteritis in pigs. II. Observations on the pathogenesis of gastroenteritis associated with Escherichia coli. Vet. Rec. 75, 1246–1250 (1963).Google Scholar
  388. Thomson, S.: The numbers of pathogenic bacilli in faeces in intestinal diseases. J. Hyg. (Camb.) 53, 217–224 (1955 a).Google Scholar
  389. Thomson, S.: The role of certain varieties of bacterium coli in gastroenteritis of babies. J. Hyg. (Camb.) 53, 357–367 (1955b),Google Scholar
  390. Toledo, M. R. F. de, Trabulsi, L. R.: Enteropathogenicidade e Comportamento Bioquimico do Colibacilo Ol36:K78 (B22). Rev. Inst. Med. trop. S. Paulo 11, 425–429(1969).PubMedGoogle Scholar
  391. Trabulsi, L. R., Toledo, M. R. F. de: Escherichia coli serogroup 0115 isolated from patients with enteritis. Biochemical characteristics and experimental pathogenicity. Rev. Inst. Med. trop. S. Paulo 11, 358–362 (1969).Google Scholar
  392. Trier, J. S.: Studies on small intestinal crypt epithelium. II. Evidence for and mechanisms of secretory activity by undifferentiated crypt cells of the human small intestine. Gastroenterology 47, 480–495 (1964).PubMedGoogle Scholar
  393. Truszczynski, M., Pilaszek, J.: Effects of injection of enterotoxin, endotoxin or live culture of Escherichia coli into the small intestine of pigs. Res. Vet. Sci. 10, 469–476 (1969).PubMedGoogle Scholar
  394. Van Heyningen, W. E., Gladstone, G. P.: The neurotoxin of shigella shigae 1. Production, purification and properties of the toxin. Brit. J. exp. Path. 34, 202–216 (1953).Google Scholar
  395. Vaughan, M., Pierce, N. F., Greenough, W. B. III.: Stimulation of glycerol production in fat cells by cholera toxin. Nature (Lond.) 226, 658–659 (1970).Google Scholar
  396. Vaughan-Williams, E. M., Dohadwalla, A. N.: The appearance of a choleragenic agent in the blood of infant rabbits infected intestinally with vibrio cholerae, demonstrated by cross circulation. J. infect. Dis. 120, 658–663 (1969).Google Scholar
  397. Vaughan-Williams, E. M., Dohadwalla, A. N.: Dutta, N. K.: Diarrhea and accumulation of intestinal fluid in infant rabbits infected with vibrio cholerae in an isolated jejunal segment. J. infect. Dis. 120, 645–651 (1969).Google Scholar
  398. Verbin, R. S., Farber, E.: Effect of cycloheximide on the cell cycle of the crypts of the small intestine of the rat. J. Cell Biol. 35, 649–658 (1967).PubMedGoogle Scholar
  399. Vernon, E.: Food poisoning in England and Wales. Mth. Bull. Minist. Hlth Lab. Serv. 24, 321–333 (1965).Google Scholar
  400. Vernon, T. M., Craig, J. P.: Unpublished observations (1967). Cited by Craig, J. P. In: Microbial toxins, vol II A, p. 189–254. New York: Academic Press 1971.Google Scholar
  401. Violle, H., Crendiropoulo: Note Sur le Cholera Expérimental. C. R. Soc. Biol. (Paris) 78, 331–332 (1915).Google Scholar
  402. Virchow, R.: Gesammelte Abhandlungen auf dem Gebiete der Öffentlichen Medizin und der Seuchenlehre, Berlin 1, 151 (1879).Google Scholar
  403. Wagman, J., Edwards, R. C, Schantz, E. J.: Molecular size, homogeneity and hydrodynamic properties of purified staphylococcal enterotoxin B. Biochemistry 4,1017–1023 (1965).PubMedGoogle Scholar
  404. Warren, S. E., Jacobson, M., Mirany, J., Prohaska, J. van: Acute and chronic enterotoxin enteritis. J. exp. Med. 120, 561–568 (1964).PubMedGoogle Scholar
  405. Warren, S. E., Sugiyama, H., Prohaska, J. van: Correlation of staphylococcal enterotoxins with experimentally induced enterocolitis. Surg. Gynec. Obstet. 116, 29–33 (1963).PubMedGoogle Scholar
  406. Watanabe, Y., Verwey, W. F.: The preparation and properties of a purified mouse protective lipopolysaccharide from the Ogawa subtype of the El Tor variety of vibrio cholerae. In: Proceedings of the Cholera Research Symposium PHS Publication 1328, p. 253–259. Washington, D. C.: U.S. Government Printing Office 1965.Google Scholar
  407. Watten, R. H., Morgan, F. M., Songkhla, Y. N., Vanikiati, B., Phillips, R. A.: Water and electrolyte studies in cholera. J. clin. Invest. 38, 1879–1889 (1959).PubMedGoogle Scholar
  408. Weaver, R. H., Johnson, M. K, Phillips, R. A.: Biochemical studies of cholera. J. Egypt, publ. Hlth Ass. 23, 5–14 (1948).Google Scholar
  409. Weiss, K. F., Strong, D. H., Groom, R. A.: Mice and monkeys as assay animals for Clostridium Perfringens food poisoning. Appl. Microbiol. 14, 479–485 (1966).PubMedGoogle Scholar
  410. Williams, E. D.: Diarrhoea and thyroid carcinoma. Proc. roy. Soc. Med. 59, 602–603 (1966).PubMedGoogle Scholar
  411. Williams, E. D.: Karim, S. M. M., Sandler, M.: Prostaglandin secretion by medullary carcinoma of the thyroid. Lancet 1968I, 22–23.Google Scholar
  412. Williams, E. P., Cameron, K.: Upon general infection by the Bacillus Pyocyaneus in children. J. Path. Bact. 3, 344–351 (1894).Google Scholar
  413. Wilson, B. J.: Comparative susceptibility of chimpanzees and macaca mulatta monkeys to oral administration of partially purified staphylococcal enterotoxin. J. Bact. 78, 240–242 (1959).PubMedGoogle Scholar
  414. Yahagi, H., Ghoda, A., Sasaki, S.: Early features of infection in ligated loops of the rabbit small intestine inoculated with Shigella flexneri 3a, enteropathogenic E. coli, Escherichia coli and Vibrio parahemolyticus. Keio J. Med. 16, 119–132 (1967).Google Scholar
  415. Zakarian, L. M.: Types of hemolysins and enterotoxins in staphylococci isolated from gastrointestinal illnesses in children. Zh. Microbiol. (Mosk.) 44, 56–58 (1967).Google Scholar
  416. Zieve, P. D., Pierce, N. F., Greenough, W. B. III.: Stimulation of glycogenosis by purified cholera enterotoxin in disrupted cells. Clin. Res. 28, 690 (1970).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1972

Authors and Affiliations

  • Daniel G. Sheahan
    • 1
  1. 1.Division of Experimental Pathology, Walter Reed Army Institute of ResearchWalter Reed Army Medical CenterUSA

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