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Structure and Biosynthesis of Viral Membranes

  • Hans-Dieter Klenk
Part of the Colloquium der Gesellschaft für Biologische Chemie 15.–17. April 1971 in Mosbach/Baden book series (MOSBACH, volume 22)

Abstract

Many animal viruses are coated by an envelope which is an integral component of the virion. During virus maturation this membrane envelops the internal component, the nucleocapsid. Upon degradation of the envelope, these viruses have lost infectivity and other biological functions. Morphologically the envelopes resemble cellular membranes, on electron micrographs they appear as unit membranes. The envelope may be formed in the cytoplasm without connexion to cellular membranes, as in the case of vaccinia virus (Dales and Mosbach, 1968). Most viruses, however, are assembled in close continuity with cellular membranes and are then released in a budding process. For instance, the envelope of herpes virus is formed at the nuclear membrane (Siegert and Falke, 1966), the envelope of certain rhabdoviruses at the membranes of intracellular vacuoles (Mussgay and Weibel, 1963), and the envelopes of arboviruses (Acheson and Tamm, 1967), RNA-tumor viruses (Beard et al., 1963) and myxoviruses at the plasma membrane of the host cell.

Keywords

Influenza Virus Viral Envelope Vesicular Stomatitis Virus Monkey Kidney Monkey Kidney Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • Hans-Dieter Klenk
    • 1
  1. 1.Institut für Virologie der Medizinischen Fakultät der Justus Liebig-UniversitätGiessenGermany

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