Skip to main content

Receptors Subserving Hunger and Thirst

  • Chapter

Part of the Handbook of Sensory Physiology book series (1729,volume 3 / 1)

Abstract

“Without eating no life, without life no drinking.” These obvious facts may explain the keen interest shown by psychologists and physiologists for the mechanisms behind the sensations of hunger and thirst. As subjective sensations hunger and thirst can only be usefully examined in ourselves. Nevertheless, psychological observations on these urges in human beings have given rise to fruitful studies in animals which have provided valuable information on the mechanisms regulating caloric and water intake. Literally, this chapter should deal only with brain receptors subserving hunger and thirst. No effort is made, therefore, to present a comprehensive picture of what is known about the complex regulations of food and water consumption. The role played by oropharyngeal, gastric, and hepatic receptors in these regulations is neglected. Still, if this chapter had to be a strict description of the nature of brain receptors subserving hunger and thirst, one, or at most two sentences would have been sufficient. These receptors have one feature in common with the Holy Ghost; they are often talked about but nobody appears to have seen them so far. This feature is no denial of the existence of either. Much evidence has been produced that central receptors involved in the regulation of eating and drinking reside in the hypothalamus and/or closely associated parts of the brain, although alimentary behaviour undoubtedly can also be modified from other parts of the brain (cf. Stevenson, 1969).

Keywords

  • Diabetes Insipidus
  • Choroid Plexus
  • Lateral Hypothalamus
  • Anterior Hypothalamus
  • Hypothalamic Lesion

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adolph, E. F.: The urge to eat and drink in rats. Amer. J. Physiol. 151, 110–125 (1947).

    PubMed  CAS  Google Scholar 

  • Anand, B. K., Brobeck, J. R.: Localization of a “feeding center” in the hypothalamus of the rat. Proc. Soc. exp. Biol. (N.Y.) 77, 323–324 (1951a).

    CAS  Google Scholar 

  • Anand, B. K., Brobeck, J. R.: Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med. 24, 123–140 (1951b).

    PubMed  CAS  Google Scholar 

  • Anand, B. K., Chhina, G. S., Sharma, K. N., Dua, S., Singh, B.: Activity of single neurons in the hypothalamic feeding centres: effect of glucose. Amer. J. Physiol. 207, 1146–1154 (1964).

    PubMed  CAS  Google Scholar 

  • Anand, B. K., Dua, S., Shoenberg, K.: Hypothalamic control of food intake in cats and monkeys. J. Physiol. (Lond.) 127, 143–152 (1955).

    CAS  Google Scholar 

  • Anand, B. K., Dua, S., Singh, B.: Electrical activity of the hypothalamic “feeding centers” under the effect of changes in blood chemistry. Electroenceph. clin. Neurophysiol. 10, 54–59 (1961a).

    Google Scholar 

  • Anand, B. K., Subberwal, U., Manchanda, S. K., Singh, B.: Glucoreceptor mechanism in the hypothalamic feeding centres. Indian. J. med. Res. 49, 717–724 (1961b).

    Google Scholar 

  • Andersson, B.: Polydipsia caused by intrahypothalamic injections of hypertonic NaCl-solutions. Experientia (Basel) 8, 157–159 (1952).

    CAS  Google Scholar 

  • Andersson, B.: The effect of injections of hypertonic NaCl-solutions into different parts of the hypothalamus of goats. Acta physiol. scand. 18, 188–201 (1953).

    Google Scholar 

  • Andersson, B., Dallman, M. F., Olsson, K.: Observations on central control of drinking and of the release of antidiuretic hormone (ADH). Life Sci. 8, 425–432 (1969).

    PubMed  CAS  Google Scholar 

  • Andersson, B., Eriksson, L., Oltner, R.: Further evidence for angiotensin-sodium interaction in central control of fluid balance. Life Sci. 9, 1091–1096 (1970b).

    CAS  Google Scholar 

  • Andersson, B., Gale, C. C., Hökfelt, B., Larsson, B.: Acute and chronic effects of preoptic lesions. Acta physiol. scand. 65, 45–60 (1965).

    Google Scholar 

  • Andersson, B., Gale, C. C., Sundsten, J. W.: Effects of chronic central cooling on alimentation and thermoregulation. Acta physiol. scand. 55, 177–188 (1962).

    PubMed  CAS  Google Scholar 

  • Andersson, B., Larsson, B.: Influence of local temperature changes in the preoptic area and rostral hypothalamus on the regulation of food and water intake. Acta physiol. scand. 52, 75–89 (1961).

    PubMed  CAS  Google Scholar 

  • Andersson, B., Larsson, B., Persson, N.: Some characteristics of the hypothalamic “drinking centre” in the goat as shown by the use of permanent electrodes. Acta physiol. scand. 50, 140–152 (1960).

    PubMed  CAS  Google Scholar 

  • Andersson, B., McCann, S. M.: Drinking, antidiuresis and milk-ejection from electrical stimulation within the hypothalamus of the goat. Acta physiol. scand. 35, 191–201 (1955).

    PubMed  CAS  Google Scholar 

  • Andersson, B., McCann, S. M.: The effect of hypothalamic lesions on the water intake of the dog. Acta physiol. scand. 35, 312–320 (1956).

    PubMed  CAS  Google Scholar 

  • Andersson, B., Olsson, K., Warner, R. G.: Dissimilarities between the central control of thirst and the release of antidiuretic hormone (ADH). Acta physiol. scand. 71, 57–64 (1967).

    PubMed  CAS  Google Scholar 

  • Andersson, B., Westbye, O.: Synergistic action of sodium and angiotensin on brain mechanisms controlling fluid balance. Life Sci. 9, 601–608 (1970a).

    CAS  Google Scholar 

  • Andersson, B., Wyrwicka, W.: The elicitation of a drinking motor conditioned reaction by electrical stimulation of the hypothalamic “drinking area” in the goat. Acta physiol scand. 41, 194–198 (1957).

    PubMed  CAS  Google Scholar 

  • Baile, C. A., Mayer, J.: Hyperphagia in ruminants induced by a depressant. Science 151, 458–459 (1966).

    PubMed  CAS  Google Scholar 

  • Baile, C. A., Mayer, J.: Effect of insulin induced hypoglycemia and hypoacetoemia on eating behavior in goats. J. Dairy Sci. 51, 1495–1499 (1968).

    PubMed  CAS  Google Scholar 

  • Bailly, P., Morrison, S. D.: The nature of the suppression of food intake by lateral hypothalamic lesions in rats. J. Physiol. (Lond.) 165, 227–245 (1963).

    Google Scholar 

  • Bellows, R. T., Wagenen, W. P. van: The relationship of polydipsia and polyuria in diabetes insipidus. A study of experimental diabetes insipidus in dogs with and without esophageal fistulae. J. nerv. ment. Dis. 88, 417–473 (1938).

    Google Scholar 

  • Bonjour, J. P., Malvin, R. L.: Stimulation of ADH release by the renin-angiotensin system. Amer. J. Physiol. 218, 1555–1559 (1970).

    PubMed  CAS  Google Scholar 

  • Bradbury, M. W. B., Davson, H.: The transport of urea, creatinine, and certain mono-sacharides between blood and fluid perfusing the cerebral ventricular system of rabbits. J. Physiol. (Lond.) 170, 195–211 (1964).

    CAS  Google Scholar 

  • Brecher, G., Waxler, S.: Obesity in albino mice due to a single injection of goldthioglucose. Proc. Soc. exp. Biol. (N.Y.) 70, 498–503 (1949).

    CAS  Google Scholar 

  • Brobeck, J. R.: Effects of variations in activity, food intake and environmental temperature on weight gain in albino rat. Amer. J. Physiol. 143, 1–5 (1945).

    CAS  Google Scholar 

  • Brobeck, J. R.: Food and temperature. Recent Progr. Hormone Res. 16, 439–466 (1960a).

    PubMed  CAS  Google Scholar 

  • Brobeck, J. R.: Regulation of feeding and drinking. In: Handbook of physiology, vol. II, sect. 1, Neurophysiology. Washington D.C.: Amer. Physiol. Soc. 1960b.

    Google Scholar 

  • Brobeck, J. R., Tepperman, J., Long, C. N. H.: Experimental hypothalamic hyperphagia in the albino rat. Yale J. Biol. Med. 15, 831–853 (1943).

    PubMed  CAS  Google Scholar 

  • Brooks, C. F., Koch, A., Wang, J.: Kinetics of sodium transfer from blood to brain of the dog. Amer. J. Physiol. 218, 693–702 (1970).

    PubMed  CAS  Google Scholar 

  • Brügger, M.: Freßtrieb als hypothalamisches Symptom. Helv. physiol. Pharmacol. Acta 1, 183–198 (1943).

    Google Scholar 

  • Cizek, L. J., Semple, R. E., Huang, K. C., Gregersen, M. I.: Effect of extracellular electrolyte depletion on water intake in dogs. Amer. J. Physiol. 164, 415–422 (1951).

    PubMed  CAS  Google Scholar 

  • Clemente, C. D., Sutin, J., Silverstone, J. T.: Changes in the electrical activity of the medulla on the intravenous injection of hypertonic solutions. Amer. J. Physiol. 188, 193–198 (1957).

    PubMed  CAS  Google Scholar 

  • Cohn, C., Joseph, D.: Influence of body weight and body fat on appetite of “normal” lean and obese rats. Yale J. Biol. Med. 34, 598–607 (1962).

    PubMed  CAS  Google Scholar 

  • Crone, C.: Facilitated transfer of glucose from blood into brain tissue. J. Physiol. (Lond.) 181, 103–113 (1965).

    CAS  Google Scholar 

  • Cross, B. A., Green, J. D.: Activity of single neurons in the hypothalamus: Effect of osmotic and other stimuli. J. Physiol. (Lond.) 148, 554–569 (1959).

    CAS  Google Scholar 

  • Csaky, T. Z., Rigor, B. M.: The choroid plexus as a glucose barrier. In: Brain barrier systems. Progr. Brain Res. 29, 147–158 (1968).

    Google Scholar 

  • Davson, H., Luck, C. P.: The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of 24Na in these fluids. J. Physiol. (Lond.) 137, 279–293 (1957).

    CAS  Google Scholar 

  • Denton, D. A.: Evolutionary aspects of the emergence of aldosterone secretion and salt appetite. Physiol. Rev. 45, 245–295 (1965).

    PubMed  CAS  Google Scholar 

  • Desiraju, T., Banerjee, M. G., Anand, B. K.: Activity of single neurons in the feeding centres: effect of 2-deoxy-d-glucose. Physiol. Behav. 3, 757–760 (1968).

    CAS  Google Scholar 

  • Epstein, A. N.: Reciprocal changes in feeding behavior produced by intrahypothalamic chemical injections. Amer. J. Physiol. 199, 969–974 (1960).

    PubMed  CAS  Google Scholar 

  • Epstein, A. N., Fitzsimons, J. T., Rolls, B. J. (née Simons): Drinking induced by injection of angiotensin into the brain of the rat. J. Physiol. (Lond.) 210, 457–474 (1970).

    CAS  Google Scholar 

  • Epstein, A. N., Fitzsimons, J. T., Simons, B. J.: Drinking caused by the intracranial injection of angiotensin into the rat. J. Physiol. (Lond.) 200, 98–100 P (1969).

    Google Scholar 

  • Epstein, A. N., Teitełbaum, P.: Severe and persistent deficits in thirst produced by lateral hypothalamic damage. In: Thirst. Oxford: Pergamon Press 1964.

    Google Scholar 

  • Erbslöh, F., Klärner, P., Bernsmeier, A.: Über die Bilanz des cerebralen Zuckerstoffwechsels. Klin. Wschr. 36, 849–852 (1958).

    PubMed  Google Scholar 

  • Euler, C. von: A preliminary note on slow hypothalamic “osmiopotentials”. Acta physiol. scand. 29, 133–136 (1953).

    Google Scholar 

  • Fisher, C., Ingram, W. R., Ranson, S.W.: Diabetes insipidus and the neuro-hormonal control of water balance. Ann Arbor, Mich.: Edwards Bros. 1938.

    Google Scholar 

  • Fitzsimons, J. T.: Drinking by rats depleted of body fluids without increase in osmotic pressure. J. Physiol. (Lond.) 159, 297–309 (1961).

    CAS  Google Scholar 

  • Fitzsimons, J. T.: The role of a renal thirst factor in drinking induced by extracellular stimuli. J. Physiol. (Lond.) 201, 349–368 (1969).

    CAS  Google Scholar 

  • Fitzsimons, J. T.: Simons, B. J.: The effect on drinking in the rat of intravenous infusion of angiotensin, given alone or in combination with other thirst stimuli. J. Physiol. (Lond.) 203, 45–57 (1969).

    CAS  Google Scholar 

  • Gasnier, A., Mayer, A.: Recherches sur la régulation de la nutrition. Ann. Physiol. Physiochim. biol. 15, 145–214 (1939).

    CAS  Google Scholar 

  • Gauer, O. H., Henry, J., Sieker, J. P., Wendt, W. E.: Heart and lungs as a receptor region controlling blood volume. Amer. J. Physiol. 167, 786–787 (1951).

    Google Scholar 

  • Gauer, O. H., Henry, J. P., Sieker, H. O., Wendt, W. E.: The effect of negative pressure breathing on urine flow. J. clin. Invest. 33, 287–296 (1954).

    PubMed  CAS  Google Scholar 

  • Gold, R. M.: Hypothalamic hyperphagia produced by parasagittal knife cuts. Physiol. Behav. 5, 23–26 (1970).

    PubMed  CAS  Google Scholar 

  • Gregersen, M. I.: The physiological mechanism of thirst. Amer. J. Physiol. 101, 44–45 (1932).

    Google Scholar 

  • Grossman, S. P.: Eating and drinking elicited by direct adrenergic or cholinergic stimulation of hypothalamus. Science 132, 301–302 (1960).

    PubMed  CAS  Google Scholar 

  • Grossman, S. P.: Behavioral effects of direct chemical stimulation of central nervous system structures. Int. J. Neuropharmacol. 3, 45–58 (1964).

    PubMed  CAS  Google Scholar 

  • Hamilton, C. L.: Food and temperature. In: Handbook of physiology, vol. I, sect. 6, Alimentary canal. Washington, D.C.: Amer. Physiol. Soc. 1967.

    Google Scholar 

  • Hamilton, C. L. Brobeck, J. R.: Food intake and temperature regulation in rats with rostral hypothalamic lesions. Amer. J. Physiol. 207, 291–297 (1964).

    PubMed  CAS  Google Scholar 

  • Hann, F. von: Über die Bedeutung der Hypophysenveränderungen bei Diabetes insipidus. Frankfurt. Z. Path. 21, 337–365 (1918).

    Google Scholar 

  • Herreveld, A. van: Brain tissue electrolytes. Molecular Biol. and Med. Series. London: Butterworths 1966.

    Google Scholar 

  • Hervey, G. R.: The effects of lesions in the hypothalamus in parabiotic rats. J. Physiol. (Lond.) 145, 336–352 (1959).

    CAS  Google Scholar 

  • Hetherington, A. W., Ranson, S. W.: Experimental hypothalamico-hypophyseal obesity in the rat. Proc. Soc. exp. Biol. (N.Y.) 41, 465–466 (1939).

    Google Scholar 

  • Hetherington, A. W., Ranson, S. W.: The spontaneous activity and food intake of rats with hypothalamic lesions. Amer. J. Physiol. 136, 609–617 (1942).

    CAS  Google Scholar 

  • Hoebel, B. G., Teitelbaum, P.: Hypothalamic control of feeding and selfstimulation. Science 135, 375–377 (1962).

    PubMed  CAS  Google Scholar 

  • Hoebel, B. G., Hypothalamic lesions by electrocauterization. Disinhibition of feeding and self-stimulation. Science 149, 452–453 (1965).

    PubMed  CAS  Google Scholar 

  • Holland, R. C., Cross, B. A., Sawyer, C. H.: EEG correlates of osmotic activation of the milk-ejection mechanism. Amer. J. Physiol. 196, 796–802 (1959).

    PubMed  CAS  Google Scholar 

  • Holmes, J. H., Cizek, L. J.: Observations on sodium chloride depletion in the dog. Amer. J. Physiol. 164, 407–414 (1951).

    PubMed  CAS  Google Scholar 

  • Holmes, J. H., Gregersen, M. I.: Observation on drinking induced by hypertonic solutions. Amer. J. Physiol. 162, 326–337 (1950).

    PubMed  CAS  Google Scholar 

  • Ingram, D. L.: Effects of heating and cooling the hypothalamus on food intake in the pig. Brain Res. 11, 714–716 (1968).

    PubMed  CAS  Google Scholar 

  • Janowitz, H. D., Ivy, A. C.: Role of blood sugar levels in spontaneous and insulin-induced hunger in man. J. appl. Physiol. 1, 643–650 (1949).

    PubMed  CAS  Google Scholar 

  • Jewell, P. A., Verney, E. B.: An experimental attempt to determine the site of the neurohypophysial osmoreceptors in the dog. Phil. Trans. B 240, 197–324 (1957).

    Google Scholar 

  • Jimenez Dias, C., Linazasoro, J. M., Castro Mendoza, H.: Further study of the part played by the kidneys in the regulation of thirst. Bull. Inst. med. Res. (Madr.) 12, 60–67 (1959).

    Google Scholar 

  • Katzman, R., Leiderman, P. H.: Brain potassium exchange in normal adult and immature rats. Amer. J. Physiol. 175, 263–270 (1953).

    PubMed  CAS  Google Scholar 

  • Keller, A. D.: Neurologically induced physiological resistence to hypothermia. Ann. N.Y. Acad. Sci. 80, 457–474 (1959).

    PubMed  CAS  Google Scholar 

  • Kennedy, G. C.: The effect of lesions in the hypothalamus on appetite. Proc. Nutr. Soc. 12, 160–165 (1953a).

    Google Scholar 

  • Kennedy, G. C.: The role of depot fat in the hypothalamic control of food intake in the rat. Proc. roy. Soc. 140, 578–592 (1953b).

    CAS  Google Scholar 

  • Kleeman, C. R., Cutler, R. E.: The neurohypophysis. Ann. Rev. Physiol. 25, 385–432 (1963).

    CAS  Google Scholar 

  • Larsson, S.: On the hypothalamic organization of the nervous mechanism regulating food intake. Acta physiol. scand. 32 (Suppl. 115), 1–63 (1954).

    CAS  Google Scholar 

  • Laszlo, F. A., Wied, D. de: Antidiuretic hormone content of the hypothalamo-neurohypophyseal system and urinary excretion of antidiuretic hormone in rats during the development of diabetes insipidus after lesions in the pituitary stalk. J. Endocr. 36, 125–137 (1966).

    PubMed  CAS  Google Scholar 

  • Leonhardt, H.: Bukettförmige Strukturen im Ependym der Regio Hypothalamica des Ventrikels beim Kaninchen. Z. Zellforsch. 88, 297–317 (1968).

    Google Scholar 

  • Leusen, I.: Influence du pH du liquide céphalo-rachidien sur la respiration. Experientia (Basel) 6, 272 (1950).

    CAS  Google Scholar 

  • Liebelt, R. A., Perry, J. H.: Hypothalamic lesions associated with goldthioglucose-induced obesity. Proc. Soc. exp. Biol. (N.Y.) 95, 774–780 (1957).

    CAS  Google Scholar 

  • Linazasoro, J. M., Jimenez Dias, C., Castro Mendoza, H.: The kidney and thirst regulation. Bull. Inst. med. Res. (Madr.) 7, 53–61 (1954).

    CAS  Google Scholar 

  • Magoun, H. W., Harrison, F., Brobeck,J. R., Ranson, S. W.: Activation of heat loss mechanisms by local heating of the brain. J. Neurophysiol. 1, 101–114 (1938).

    Google Scholar 

  • Marshall, N. B., Mayer, J.: Energy balance in goldthioglucose obesity. Amer. J. Physiol. 178, 271–276 (1954).

    PubMed  CAS  Google Scholar 

  • Massopust, L. C., Jr.: The hypothalamic syndrome in rats with experimental lesions. Neurology (Minneap.) 5, 472–478 (1955).

    Google Scholar 

  • Mayer, A.: Essai sur la soif: Ses causes et son méchanisme. Thesis. Paris: Jouve & Boyer 1900.

    Google Scholar 

  • Mayer, J.: Genetic, traumatic, and environmental factors in the ethology of obesity. Physiol. Rev. 33, 472–508 (1953).

    PubMed  CAS  Google Scholar 

  • Mayer, J.: Physiological and nutritional aspects of obesity. Rev. Nutr. Res. 19, 35–55 (1958).

    CAS  Google Scholar 

  • Mayer, J., Barnett, R.: Unilateral lesions of N. ventromedialis and obesity in rat. Science 121, 599 (1955).

    PubMed  CAS  Google Scholar 

  • Mayer, J., Marshall, N. B.: Specificity of goldthioglucose for ventromedial hypothalamic lesions and hyperphagia. Nature (Lond.) 178, 1399–1400 (1956).

    CAS  Google Scholar 

  • Miller, N. E.: Some motivational effects of brain stimulation and drugs. Fed. Proc. 19, 846 (1960).

    PubMed  CAS  Google Scholar 

  • Miller, N. E., Bailey, C. J., Stevenson, J. A. F.: Decreased “hunger” but increased food intake resulting from hypothalamic lesions. Science 112, 256–259 (1950).

    PubMed  CAS  Google Scholar 

  • Mitchell, R. A., Loeschcke, H. H., Massion, W. H., Severinghaus,J. W.: Respiratory responses mediated through superficial chemisensitive areas on the medulla. J. appl. Physiol. 18, 523–533 (1963).

    CAS  Google Scholar 

  • Montemurro, D. G., Stevenson, J. A. F.: Adipsia produced by hypothalamic lesions in the rat. Canad. Biochem. Physiol. 35, 31–37 (1957).

    CAS  Google Scholar 

  • Morgane, J. P.: Medial forebrain bundle and “feeding centers” of the hypothalamus. J. comp. Neurol. 117, 1–26 (1961b).

    PubMed  CAS  Google Scholar 

  • Morgane, J. P., Jacobs, H. L.: Hunger and satiety. Wld Rev. Nutr. Diet. 10, 100–213 (1969).

    CAS  Google Scholar 

  • Morgane, P. J.: Evidence of a “hunger motivational” system in the lateral hypothalamus of the rat. Nature (Lond.) 191, 672–674 (1961a).

    CAS  Google Scholar 

  • O’Connor, W. J.: The normal interphase in the polyuria which follows section of the supraoptico-hypophysial tracts in the dog. Quart. J. exp. Physiol. 37, 1–10 (1952).

    PubMed  Google Scholar 

  • Olsson, K.: Studies on central regulation of secretion of antidiuretic hormone (ADH) in the goat. Acta physiol. scand. 77, 465–474 (1969).

    PubMed  CAS  Google Scholar 

  • Olsson, K.: Relations of polyuria and polydipsia in experimental diabetes insipidus. Acta physiol. scand. 78, 20–27 (1970).

    PubMed  CAS  Google Scholar 

  • Oomura, Y., Ono, T., Ooyama, H., Wayner, M. J.: Glucose and osmosensitive neurones of the rat hypothalamus. Nature (Lond.) 222, 282–284 (1969).

    CAS  Google Scholar 

  • Park, C. R., Johnson, L. H., Wright, J. H., Batsel, H.: Effect of insulin on transport of several hexoses and pentoses into cells of muscle and brain. Amer. J. Physiol. 191, 13–18 (1957).

    PubMed  CAS  Google Scholar 

  • Peart, W. S.: The renin-angiotensin system. Pharmacol. Rev. 17, 143–182 (1965).

    PubMed  CAS  Google Scholar 

  • Rodgers, W. L., Epstein, A.N., Teitelbaum, P.: Lateral hypothalamic aphagia: motor failure or motivational deficit? Amer. J. Physiol. 208, 334–342 (1965).

    PubMed  CAS  Google Scholar 

  • Rowe, G. G., Maxwell, G. M., Castillo, C.A., Crtjmption, C. W.: A study in man of cerebral blood flow and cerebral glucose, lactate, and pyruvate metabolism before and after eating. J. clin. Invest. 38, 2154–2158 (1959).

    PubMed  CAS  Google Scholar 

  • Sawyer, C. H., Gernandt, B. E.: Effects of intracarotid and intraventricular injections of hypertonic solutions on electrical activity of the rabbit brain. Amer. J. Physiol. 185, 209–216 (1956).

    PubMed  CAS  Google Scholar 

  • Simkins, K. L., Suttie, J. W., Baumgardt, B. R.: Regulation of food intake in ruminants. 3. Variation in blood and rumen metabolites in relation to food intake. J. Dairy Sci. 48, 1629–1634 (1965).

    Google Scholar 

  • Smith, G. P., Epstein, A. N.: Increased feeding in response to decreased glucose utilization in the rat and monkey. Amer. J. Physiol. 217, 1083–1087 (1969).

    PubMed  CAS  Google Scholar 

  • Smith, R. W., McCann, S. M.: Increased and decreased water intake in the rat with hypothalamic lesions. Proc. 1st int. Symp. Thirst, p. 381–392. Oxford: Pergamon Press 1964.

    Google Scholar 

  • Spector, N. H., Brobeck, J. R., Hamilton, C. L.: Feeding and core temperature in albino rats: Changes induced by preoptic heating and cooling. Science 161, 286–288 (1968).

    PubMed  CAS  Google Scholar 

  • Stevenson, J. A. F.: Effects of hypothalamic lesions on water and energy metabolism in the rat. Recent Progr. Hormone Res. 4, 363–394 (1949).

    Google Scholar 

  • Stevenson, J. A. F.: Neural control of food and water intake. In: Hypothalamus, pp. 524–621. Springfield, Ill.: C.C.Thomas 1969.

    Google Scholar 

  • Stevenson, J. A. F.: Box, B. M., Montemurro, D. G.: Evidence of possible association pathways for the regulation of food and water intake in the rat. Canad. J. Physiol. Pharmacol. 42, 855–860 (1964).

    CAS  Google Scholar 

  • Stevenson, J. A. F., Welt, L. G., Orloff, J.: Abnormalities of water and electrolyte metabolism in rats with hypothalamic lesions. Amer. J. Physiol. 161, 35–39 (1950).

    PubMed  CAS  Google Scholar 

  • Stunkard, A. J., Itallie, B. van, Reis, B. B.: The mechanism of satiety: effect of glucagon on gastric hunger contractions in man. Proc. Soc. exp. Biol. (N.Y.) 89, 258–261 (1955).

    CAS  Google Scholar 

  • Stunkard, A. J., Wolff, H. G.: Correlation of arteriovenous glucose differences, gastric hunger contractions and the experience of hunger in man. Fed. Proc. 13, 147 (1954).

    Google Scholar 

  • Sundsten, J. W., Sawyer, C. H.: Electro-encephalographic evidence of osmosensitive elements in olfactory bulb of dog brain. Proc. Soc. exp. Biol. (N.Y.) 101, 524–527 (1959).

    Google Scholar 

  • Teitelbaum, P.: Sensory control of hypothalamic hyperphagia. J. comp. physiol. Psychol. 48, 156–163 (1955).

    PubMed  CAS  Google Scholar 

  • Teitelbaum, P.: Random and food-directed activity in hyperphagic and normal rats. J. comp. physiol. Psychol. 50, 486–490 (1957).

    PubMed  CAS  Google Scholar 

  • Teitelbaum, P., Epstein, A. N.: The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions. Psychol. Rev. 69, 74–90 (1962).

    PubMed  CAS  Google Scholar 

  • Teitelbaum, P., Stellar, E.: Recovery from the failure to eat, produced by hypothalamic lesions. Science 120, 894–895 (1954).

    PubMed  CAS  Google Scholar 

  • Verney, E. B.: The antidiuretic hormone and factors which determine its release. Proc. roy. Soc. B 135, 25–106 (1947).

    CAS  Google Scholar 

  • Vincent, J. D., Hayward, J. N.: Activity of single cells in the osmoreceptor-supraoptic nuclear complex in the hypothalamus of the waking rhesus monkey. Brain Res. 23, 105–108 (1970).

    PubMed  CAS  Google Scholar 

  • Witt, D. M., Keller, A. D., Batsel, H. L., Lynch, J. R.: Absence of thirst and resultant syndrome associated with anterior hypothalamectomy in the dog. Amer. J. Physiol. 171, 780 (1952).

    Google Scholar 

  • Wolf, A. V.: Osmometric analysis of thirst in man and dog. Amer. J. Physiol. 161, 75–86 (1950).

    PubMed  CAS  Google Scholar 

  • Woodbury, D. M.: Distribution of nonelectrolytes and electrolytes in the brain as effected by alterations in cerebrospinal fluid secretion. In: Brain barrier systems, pp. 297–314. Amsterdam: Elsevier publ. comp. 1968.

    Google Scholar 

  • Woodward, G. E., Hudson, M. T.: The effect of 2-deoxy-D-glucose on glucolysis and respiration of tumor and normal tissues. Cancer Res. 14, 599–605 (1954).

    PubMed  CAS  Google Scholar 

  • Wyrwicka, W., Dobrzecka, C.: Relationship between feeding and satiation centers of the hypothalamus. Science 132, 805–806 (1960).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1972 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Andersson, B. (1972). Receptors Subserving Hunger and Thirst. In: Neil, E. (eds) Enteroceptors. Handbook of Sensory Physiology, vol 3 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65252-3_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-65252-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65254-7

  • Online ISBN: 978-3-642-65252-3

  • eBook Packages: Springer Book Archive