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Interrelationships between Adrenergic and Cholinergic Mechanisms

  • Chapter
Catecholamines

Abstract

After Loewi (1921) had shown that impulse transmission from the autonomic nerves to the effector organ may be mediated by chemical agents, the classical theory of humoral transmission was developed; it was assumed that, with few exceptions, the fibres of the sympathetic outflow were adrenergic and those of the parasympathetic outflow cholinergic. This assumption was based on experiments in mammals; only little information was available on the transmitters in the autonomic nervous system of non-mammalian vertebrates. Burnstock (1969) has summarized the position as follows: The primitive sympathetic excitatory supply to the viscera of fish and amphibia is predominantly cholinergic. There are various proportions of adrenergic and cholinergic fibres in sympathetic trunks in reptiles and birds while in mammals most, and sometimes all, of the fibres in sympathetic trunks are adrenergic.

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Authors
  1. H. W. Kosterlitz
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  2. G. M. Lees
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Editors and Affiliations

  1. University Department of Pharmacology, South Parks Road, Oxford, OX1 3QT, Great Britain

    H. Blaschko

  2. Abt. für Neuropharmakologie, Pharmakologisches Institut der Universität, Obere Zahlbacher Str. 67, D-65, Mainz, Germany

    E. Muscholl

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Kosterlitz, H.W., Lees, G.M. (1972). Interrelationships between Adrenergic and Cholinergic Mechanisms. In: Blaschko, H., Muscholl, E. (eds) Catecholamines. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65249-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-65249-3_17

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  • Online ISBN: 978-3-642-65249-3

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