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Factors Influencing the Concentration of Catecholamines at the Receptors

  • Chapter
Catecholamines

Abstract

There are no methods available for the direct determination of the concentration of noradrenaline in the “biophase”, i.e., in the very small part of the extracellular space in the immediate neighbourhood of the receptors of adrenergically innervated organs. Hence, any discussion of the factors influencing the concentration of the amine at the receptors has to be based on indirect evidence. If the direct approach is impossible, one can gain some insight from recording responses (or changes in responses) of the effector organ to known concentrations of noradrenaline. However, any interpretation involves two crucial assumptions, namely that, in the absence of conclusive evidence to the contrary, the interaction between drug and receptor as well as the function of the link between receptor activation and eventual response remains unaffected by the change in experimental conditions which is being studied. In many experimental situations the validity of these assumptions remains questionable, since it has not been possible to obtain positive evidence.

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  1. U. Trendelenburg
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Editors and Affiliations

  1. University Department of Pharmacology, South Parks Road, Oxford, OX1 3QT, Great Britain

    H. Blaschko

  2. Abt. für Neuropharmakologie, Pharmakologisches Institut der Universität, Obere Zahlbacher Str. 67, D-65, Mainz, Germany

    E. Muscholl

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Trendelenburg, U. (1972). Factors Influencing the Concentration of Catecholamines at the Receptors. In: Blaschko, H., Muscholl, E. (eds) Catecholamines. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65249-3_16

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