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Effect of Other Hormones Upon Resistance

  • Hans Selye
Chapter
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Abstract

The influence of ACTH upon various actions of mineralocorticoids (Selye C92,918/61, p. 18; G60,083/70, pp. 328–332) and MAD (Selye G60,083/70, pp. 328, 330) has been discussed elsewhere. Let us add here that in rats ACTH (like adrenocortical extract) antagonizes many manifestations of overdosage with DOC, such as the: hypernatremia, EST-elevation, and insulin hypersensitivity, as well as the hyalinosis syndrome produced after uninephrectomy + NaCl. Conversely, the hyalinosis elicited by MAD is actually aggravated by ACTH. This singular “DOC-like” effect is presumably due to the inhibition by MAD of 11β-hydroxylation in the adrenals; in the presence of this enzymic defect the corticotrophic action of ACTH shifts towards an excess secretion of DOC which has no 11β-OH group.

Keywords

Thyroid Hormone Osteitis Fibrosa Alloxan Diabetes Thyroid Extract Thymus Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1971

Authors and Affiliations

  • Hans Selye
    • 1
  1. 1.Institut de Médecine et de Chirurgie expérimentalesUniversité de MontréalMontrealCanada

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