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The Metabolism of Analogs of Endogenous Substrates: Wider Application of a Limited Concept

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Concepts in Biochemical Pharmacology

Abstract

Substrate analogs may be defined as compounds which bear a close chemical and/or physical resemblance to a constituent of normal tissue and which may replace the latter in one or more of its normal reactions, usually leading to a metabolic block. The substrate analogs, or antimetabolites, usually compete with the natural substrate at the same site on an enzyme. Actually, only a portion of the antimetabolite molecule must be analogous for competition.

The preparation of this review was supported by USPHS research grants CA 02978 from the National Cancer Institute, and GM-13749 from the National Institute of General Medical Sciences, NIH, Bethesda, Md.

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  1. H. George Mandel
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Mandel, H.G. (1971). The Metabolism of Analogs of Endogenous Substrates: Wider Application of a Limited Concept. In: Brodie, B.B., Gillette, J.R., Ackerman, H.S. (eds) Concepts in Biochemical Pharmacology. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 28 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65177-9_37

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