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Dynamic Blood Coagulation: Effect of Velocity Gradient on the Clotting Times, Rheology and Morphology of Clots and Thrombi in Normals and Patients

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Theoretical and Clinical Hemorheology

Abstract

Blood coagulation, clot retraction and fibrinolysis are generally studied under static conditions. These may bear little relevance to the physiological conditions in which they proceed under varying rates of flow and flow velocity. Similarly, the morphology of static (glass tube) clots differs greatly from the morphology of thrombi formed in veins and arteries. Glass tube clots show no visible platelet aggregates and are made up entirely of a random fibrin network with adherent or enmeshed red cells. A venous throm bus contains some platelet masses, whilst an arterial thrombus has large amorphous masses of platelet aggregates surrounded by leucocytes (1).

This study was supported by the National Heart Foundation of Australia.

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Author information

Authors and Affiliations

  1. Hemorheology Laboratory, Department of Medicine, University of Sydney, Australia

    L. Dintenfass

  2. Hemorheology Unit, Sydney Hospital, Sydney, Australia

    L. Dintenfass

  3. Institute of Child Health, Royal Alexandra, Hospital for Children, Australia

    J. S. Yu

  4. Repatriation Hospital, Concord, NSW, Australia

    C. Grace

Authors
  1. L. Dintenfass
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  2. J. S. Yu
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  3. C. Grace
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Editor information

Editors and Affiliations

  1. Städtisches Krankenhaus, Kaiserslautern, West Germany

    Hellmut H. Hartert (Medical Director Professor of Medicine) (Medical Director Professor of Medicine)

  2. Medical Faculty, Saar University, Homburg/Saarbrücken, West Germany

    Hellmut H. Hartert (Medical Director Professor of Medicine) (Medical Director Professor of Medicine)

  3. Hemorrhage and Thrombosis Research Laboratories, USA

    Alfred L. Copley (Chief Research Director Adjunct Research Professor of Bioengineering) (Chief Research Director Adjunct Research Professor of Bioengineering)

  4. Department of Pharmacology, New York Medical College, New York, NY, 10029, USA

    Alfred L. Copley (Chief Research Director Adjunct Research Professor of Bioengineering) (Chief Research Director Adjunct Research Professor of Bioengineering)

  5. Newark College of Engineering, Newark, NY, 07102, USA

    Alfred L. Copley (Chief Research Director Adjunct Research Professor of Bioengineering) (Chief Research Director Adjunct Research Professor of Bioengineering)

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© 1971 Springer-Verlag Berlin • Heidelberg

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Dintenfass, L., Yu, J.S., Grace, C. (1971). Dynamic Blood Coagulation: Effect of Velocity Gradient on the Clotting Times, Rheology and Morphology of Clots and Thrombi in Normals and Patients. In: Hartert, H.H., Copley, A.L. (eds) Theoretical and Clinical Hemorheology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65156-4_39

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  • DOI: https://doi.org/10.1007/978-3-642-65156-4_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65158-8

  • Online ISBN: 978-3-642-65156-4

  • eBook Packages: Springer Book Archive

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