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Changes in the Properties of Ribosomes and Transfer RNA Induced by Inhibitors of Protein Synthesis

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Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 2))

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Abstract

Since the discovery that chloramphenicol binds to ribosomes (Vazquez, D., 1964; Wolfe and Hahn, 1965) other inhibitors of protein synthesis also have been found to associate with ribosomes in vitro. These antibiotics can be classified according to their specificity towards the ribosomes (Vazquez, Staehelin, Celma, Battaner, Fernandez-Munoz and Monro, 1969). Two main classes exist, one affecting only the 70S ribosomes, the other interacting with both, 70S and 80S ribosomes. The substances which bind to the 70S ribosomes can be subdivided further into one group which specifically interacts with the 30S subunit and another group which binds to the 50S subunit. Likewise inhibitors affecting the 80S ribosomes can be classified depending on whether they associate with the 40S or with the 60S subunit.

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Authors
  1. Helga Kersten
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Editors and Affiliations

  1. Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C., 20012, USA

    Fred E. Hahn

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© 1971 Springer-Verlag Berlin · Heidelberg

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Kersten, H. (1971). Changes in the Properties of Ribosomes and Transfer RNA Induced by Inhibitors of Protein Synthesis. In: Hahn, F.E. (eds) Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action. Progress in Molecular and Subcellular Biology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65141-0_7

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  • DOI: https://doi.org/10.1007/978-3-642-65141-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65143-4

  • Online ISBN: 978-3-642-65141-0

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