Abstract
Paul Ehrlich (1913) observed, first, the occurrence of “relapsing crops” of parasites in animals under experimental chemotherapy, i.e. of strains which had developed resistance to chemotherapeutic drugs. This discovery was subsequently forgotten until the advent of antibacterial chemotherapy and the emergence of bacterial strains which were resistant either to sulfonamides or to antibiotics.
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De Courcy, S.J. (1971). Antimutagens and Antimicrobial Drug Resistance. In: Hahn, F.E. (eds) Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action. Progress in Molecular and Subcellular Biology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65141-0_24
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