Interaction of Antimalarial Aminoquinolines (Primaquine, Pentaquine, and Chloroquine) with Nucleic Acids, and Effects on Various Enzymatic Reactions in Vitro

  • David J. HolbrookJr.
  • Leona P. Whichard
  • Carl R. Morris
  • Lidia A. White
Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 2)


Two classes of aminoquinolines are effective as antimalarial drugs. The 4-aminoquinolines, including the prototype chloroquine, are active against the erythrocytic stage of Plasmodia. In contrast, the 8-aminoquinolines, including as representatives primaquine and pentaquine, are active against the tissue stages of the malaria parasite (Powell, 1966). In addition, chloroquine is also used for several other parasitic diseases and for rheumatoid arthritis.


Equilibrium Dialysis Plasmodium Berghei Micrococcal Nuclease Plasmodium Knowlesi Pancreatic RNase 
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© Springer-Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • David J. HolbrookJr.
  • Leona P. Whichard
  • Carl R. Morris
  • Lidia A. White

There are no affiliations available

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