The Effect of Cyclophosphamide Treatment on Immunological Competence as Measured by the Mixed Lymphocyte Reaction

  • M. R. Schwarz


Cyclophosphamide, an immunosuppressive agent commonly known as Cytoxan, currently enjoys widespread popularity in medicine [1]. In spite of this, one major drawback to its broader application is the absence of an in vitro assay that will assess the immunological status of individuals treated with this drug. Recently, it has been recognized that the mixed lymphocyte reaction (MLR) can detect permanent states of tissue tolerance [2] and can also monitor the temporary immunological depression induced by antilymphocytic serum [3], radiation [4], and thymectomy with or without antilymphocytic serum treatment [5]. Because of these findings, the present study was undertaken to determine if the MLR could detect the immunosuppression induced by cyclophosphamide and if so, whether it could monitor this suppression on a temporal basis.


Transfer Reaction Thoracic Duct Mixed Lymphocyte Reaction Cyclophosphamide Treatment Tissue Tolerance 
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© Springer Verlag Berlin · Heidelberg 1971

Authors and Affiliations

  • M. R. Schwarz

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