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Comparative Aspects of Anesthesia in Animals

  • L. R. Soma
  • H. W. Calderwood
Part of the Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology book series (HEP, volume 30)

Abstract

The interest in veterinary anesthesia has increased considerably, with greater focus on anesthesia as an important part of animal management and care. The approach and attitude has shifted from anesthesia as being only a necessary part of a surgical procedure to a greater overall awareness of its importance in the management of the animal from the preoperative through to the postoperative period. Along with the growing awareness of the practicing veterinarian in the greater use of newer anesthetic agents and techniques, has been an increased interest on the part of the experimental surgeon and research worker in better anesthetic methods. There has also been a greater concern for the impact of drugs and anesthetic agents on experimental results. Unfortunately, herein lies one of the greatest deficiencies of our knowledge of general anesthesia. The rapid development of the field of biomedical engineering has given the research scientist the means for the development of more sophisticated chronic models. This has placed a greater responsibility on the researcher for the use of better anesthetic techniques and a greater awareness on pre and postoperative care.

Keywords

Tracheal Intubation Anesthetic Agent Comparative Aspect Divinyl Ether Respiratory Minute Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adamson, D. W., Green, A. F.: New series of analgesics. Nature 165, 122 (1950).PubMedCrossRefGoogle Scholar
  2. Adriani, J., Yarberry, O. H., Jr.: Preanesthetic medication. Old and new concepts. Arch. Surg. 79, 976 (1959).PubMedGoogle Scholar
  3. Ayre, P.: The T-piece technique. Brit. J. Anaesthesia 28, 520 (1956).CrossRefGoogle Scholar
  4. Bahga, H. S., Link, R. P.: Cardiovascular effects of two phenothiazines: fluphenazine and trifluoperazine. Am. J. Yet. Research 27, 81 (1966).Google Scholar
  5. Baratta, A., Brandslater, B., Muallem, M., Seraphim, C.: Rebreathing in a double T-piece system. Brit. J. Anaesthesia 4, 47 (1969).Google Scholar
  6. Bennett, R. R.: The clinical use of 2-(ethylamino)-2-(2-thienyl) cyclohexanone HC1 (CI 634) as an anesthetic for the cat. Am. J. Yet. Research 30, 1469 (1969).Google Scholar
  7. Booth, N. H., Rankin, A. D.: Evaluation of meperidine hydrochloride in the cat. Yet. Med. 49, 249 (1954).Google Scholar
  8. Boulos, B. M., Davis, L. E.: Hazard of simultaneous administration of phenothiazine and piperazine. New Engl. J. Med. 280, 1245 (1969).PubMedGoogle Scholar
  9. Bourgeois-Gavardin, M., Nowill, W. K., Margolis, G., Stephen, C. R.: Chlorpromazine, a laboratory and clinical investigation. Anesthesiology 16, 829 (1955).PubMedCrossRefGoogle Scholar
  10. Boutelle, J. L., Rich, S. T.: An anesthetic chamber for prolonged immobilization of mice during tumor transplantation and radiation procedures. Lab. An. Care 19, 666 (1969).Google Scholar
  11. Bree, M. M., Feller, I., Corssen, G.: Safety and tolerance of repeated anesthesia with CI 581 (ketamine) in monkeys. Anesthesia Current Researches & Analgesia 46, 596 (1967).Google Scholar
  12. Burn, J. H., Epstein, H. G., Fergan, G. A., Paton, W. D. M., Burns, T. H. S., Mushin, W. W., Organe, G. S. W., Robertson, J. D.: Fluothane: A report to the Medical Research Council by the Committee on Non-explosive Anesthetic Agents. Brit. Med. J. 2, 479 (1957).PubMedCrossRefGoogle Scholar
  13. Burstein, C. L., LoPinto, F. J., Newman, W.: Electrocardiographic studies during endotracheal intubation; effects during usual routine technics. Anesthesiology 11, 224 (1950).PubMedCrossRefGoogle Scholar
  14. Calderwood, H., Klide, A., Cohn, B., Soma, L.: The effects of tilitamine (CI 634) in the cat. Am. J. Yet. Research (in press).Google Scholar
  15. Calderwood, H., Klide, A., Soma, L.: Department of Clinical Studies, Section of Anesthesia, University of Pennsylvania Veterinary School, Philadelphia, Pennsylvania. Unpublished data, 1970.Google Scholar
  16. Carey, F. M., Sanford, J.: A method of assessing the effect of drugs on the performance in the horse. Proc. Brit. Eq. Assoc. 52, (1965).Google Scholar
  17. Carlson, W. D.: A clinical evaluation of meperidine hydrochloride as a preanesthetic agent in the cat. Vet. Med. 50, 229 (1955).Google Scholar
  18. Chen, G., Ensor, C. R.: 2-(ethylamino)-2-(2-thienyl) cyclohexanone HC1 (CI 634): A taming, incapacitating, and anesthetic agent for the cat. Am. J. Yet. Research 29, 863 (1968).Google Scholar
  19. Chen, G., Ensor, C. R., Russell, D., Bohner, B.: The pharmacology of l-(l-phencylcyclohexyl) piperidine HC1. J. Pharmacol. Exptl. Therap. 127, 241 (1959).Google Scholar
  20. Clarke, K. W., Hall, L. W.: Xylazine — a new sedative for horses and cattle. Vet. Record 85, 512 (1969).CrossRefGoogle Scholar
  21. Clifford, D. H., Soma, L. R.: Chapter 22, Feline Medicine and Surgery, 1st Ed. Santa Barbara, Calif.: American Veterinary Publications, Inc. 1964.Google Scholar
  22. Collard, J. A.: Unusual reaction to chlorpromazine hydrochloride in a bich. Australian Vet. J. 34, 90 (1958).CrossRefGoogle Scholar
  23. Collette, W. L., Meriwether, W. F.: Some changes in the peripheral blood of dogs after administration of certain tranquillizers and narcotics. Vet. Med./Small Animal Clinician 60, 1223 (1965).Google Scholar
  24. Collins, R. J.: Potency of dihydromorphinone, methadone, and codeine compared to morphine in self-maintained addict rats. Federation Proc. 22, 248 (1963).Google Scholar
  25. Conney, A. H.: Pharmacological implications of microsomal enzyme induction. Pharmacol. Revs 19, 317 (1967).Google Scholar
  26. Corssen, G., Domino, E. F.: Dissociative anesthesia: further pharmacologic studies and first clinical experience with phencyclidine derivative CI-581. Current Researches Anesthesia & Analgesia 45, 29 (1966).Google Scholar
  27. Dobkin, A. B.: Potentiation of thiopental anaesthesia with Tigan, Panectyl, Benadryl, Gravol. Marzine, Histadyl, Librium, Haloperidol (R 1625). Canad. Anaesth. Soc. J. 8, 265 (1961).Google Scholar
  28. Domino, E. F.: Neurobiology of phencyclidine (Sernyl), a drug with an unusual spectrum of pharmacological activity. Intern. Rev. Neurobiol. 6, 303 (1964).CrossRefGoogle Scholar
  29. Domino, E. F., Chodoff, P., Corssen, G.: Pharmacologic effects of CI-581, a new dissociative anesthetic in man. Clin. Pharmacol. Therap. 6, 279 (1965).Google Scholar
  30. Dripps, R. D., Eckenhoff, J. E., Vandam, L. D.: Introduction to anesthesia, 2nd ed. Philadelphia, Pa.: Saunders, W. B. 1961.Google Scholar
  31. Dundee, J. W.: Thiopentone and other thiobarbiturates. London: E. and S. Livingstone, LTD 1956.Google Scholar
  32. Editorial. Anesthesiology 25, 3 (1964).CrossRefGoogle Scholar
  33. Epling, G. P., Rankin, A. D.: Metopon analgesia in the dog. Am. J. Vet. Research 15, 338 (1954).Google Scholar
  34. Feldberg, W., Paton, W. D. M.: Release of histamine by morphine alkaloids. J. Physiol. (London) 111, 19 (1950).Google Scholar
  35. Flyger, V.: Handling wild mammals with new tranquillizer. Trans. Twenty-Sixth North Am. Wildlife and Natural Resourses Conf., 230, 1961.Google Scholar
  36. Fowler, W. S.: Lung function studies, respiratory dead space. Am. J. Physiol. 154, 405 (1948).PubMedGoogle Scholar
  37. Friedman, J. J.: Effect of Nembutal on circulating and tissue blood volumes and hematocrits of intact and splenectomezed mice. Am. J. Physiol. 197, 399 (1959).PubMedGoogle Scholar
  38. Gabel, A. A., Hamlin, R., Smith, C. R.: Effects of promazine and chloral hydrate on the cardiovascular system of the horse. Am. J. Vet. Research 25, 1151 (1964).Google Scholar
  39. Gabel, A. A., Koestner, A.: The effects of intracarotid artery injection of drugs in animals. J. Am. Vet. Med. Assoc. 142, 1397 (1963).PubMedGoogle Scholar
  40. Godeaux, J., Innesen, M.: Investigations into atropine metabolism in animal organism. Acta Pharmacol. Toxicol. 5, 95 (1949).CrossRefGoogle Scholar
  41. Goodman, L. S., Gilman, A.: The pharmacological basis of therapeutics, 3rd ed. New York: Macmillan Co. 1965.Google Scholar
  42. Graham-Jones, O.: (1) Restraint and anaesthesia of some captive wild mammals. Vet. Record 76, 1216 (1964).Google Scholar
  43. Graham-Jones, O. (2) Discussion of Smits, G. M.: Some experiments and experiences with neuroleptic and hypnotic drugs on ungulates with special regard to Librium. Proceed, of Fifth Internat. Symp. on Disease of Zoo Animals. Royal Neth. Vet. Assoc. Tij. Dierg. 89, 195 (1964).Google Scholar
  44. Graham-Jones, O., Tranquillizer and paralytic drugs. An international survey of animal restraint techniques. Intern. Zoo Yearbook 2, 300 (1960).CrossRefGoogle Scholar
  45. Hall, L. W.: Wright’s veterinary anesthesia and analgesia, 6th ed. Baltimore, Md.: William and Wilkings Co. 1966.Google Scholar
  46. Hall, L. W., Stevenson, D. F.: Effects of ataractic drugs on the blood pressure and heart rate of dogs. Nature 187, 696 (1960).PubMedCrossRefGoogle Scholar
  47. Harrison, G. A.: Ayre’s T-piece: A review of its modifications. Brit. J. Anaesthesia 36, 118 (1964).Google Scholar
  48. Harthoorn, A. M.: Application of pharmacological and physiological principles in restraint of wild animals. Wildlife Monograph 14, 1 (1965).Google Scholar
  49. Harthoorn, A. M., (1) On the use of phencyclidine for narcosis in the larger animals. Yet. Record 74, 410 (1962).Google Scholar
  50. Harthoorn, A. M., (2) Producing “twilight sleep” in large wild mammals. J. Am. Vet. M.d. Assoc. 141, 1473 (1962).Google Scholar
  51. Harthoorn, A. M., Textbook of veterinary anesthesiology (Soma, L. R., Ed.), Chapter 29. The capture and restraint of wild animals. Baltimore, Md.: Williams and Wilkins Co. 1971.Google Scholar
  52. Heavner, J. E.: Morphine for postsurgical use in cats. J. Am. Vet. Med. Assoc. 156, 1018 (1970).PubMedGoogle Scholar
  53. Hoe, C. M., Wilkinson, J. S.: A diluting effect of chlorpromazine hydrochloride on the circulating blood of dogs. Vet. Record 69, 734 (1957).Google Scholar
  54. Hutchinson, B. R.: Changes in pulse rate and blood pressure after extubation. Brit. J. Anaesthesia 86, 661 (1964).CrossRefGoogle Scholar
  55. Hutchinson, B. R., Electrocardiographic changes in children following extubation. Med. J. Australia 1, 151 (1956).Google Scholar
  56. Johnstone, M.: Pethidine and general anesthesia. Brit. Med. J. 2, 943 (1951).PubMedCrossRefGoogle Scholar
  57. Kaelber, W. W., Toynt, R. J.: Tremor production in cats given chlorpromazine. Proc. Soc. Exptl. Biol. Med. 92, 399 (1956).Google Scholar
  58. Kain, L. M., Nunn, J. F.: Fresh gas economics of the Magill Circuit. Anesthesiology 29, 964 (1968).PubMedCrossRefGoogle Scholar
  59. Killip, T.: Sinus nerve stimulation in the chloralose anesthetized cat: Effect on blood pressure, heart rate, muscle blood flow and vascular resistance. Acta Physiol. Scand. 57, 437 (1963).PubMedCrossRefGoogle Scholar
  60. King, B. D., Harris, L. C., Jr., Greifenstein, F. E., Elder, J. D., Jr., Dripps, R. D.: Reflex circulatory responses to direct laryngoscopy and tracheal intubation performed during general anesthesia. Anesthesiology 12, 556 (1961).CrossRefGoogle Scholar
  61. Kroll, W. R.: Experience with Sernylan in zoo animals. Intern. Zoo Yearbook 4, 131 (1962).CrossRefGoogle Scholar
  62. Kruegar, H., Eddy, N. B., Sumwalt, M.: The pharmacology of the opium alkaloids. Supplement 165. Pub. Health Rep., U.S. Government Printing Office, Washington, D.C., Part I, 1941, Part I I, 1943.Google Scholar
  63. Lewis, R. N., Swerdlow, M.: Hazards of endotracheal anesthesia. Brit. J. Anaesthesia 36, 504 (1964).CrossRefGoogle Scholar
  64. Lowenstein, E., Mallowell, P., Levine, H., Daggett, W. M., Austen, W., Lavor, M. B.: Cardiovascular response to large doses of intravenous morphine in man. New Engl. J. Med. 281, 1389 (1969).PubMedCrossRefGoogle Scholar
  65. Mapelson, W. W.: The elimination of rebreathing in various semiclosed anesthetic systems. Brit. J. Anaesthesia 26, 323 (1954).CrossRefGoogle Scholar
  66. Martin, J. E., Beck, J. D.: Some effects of chlorpromazine in horses. Am. J. Vet. Research. 17, 678 (1958).Google Scholar
  67. Matorras, A. A., Felipe, M. A. N.: Selection of indications on the use of CI-581 and observations on 198 cases. Progress in Anaesthesiology, Proceedings of the Fourth World Congress of Anaesthesiologists, p. 1000, London 1968. Excerpta Med. Foundation, Amsterdam 1970.Google Scholar
  68. Medd, R. K., Heywood, R.: A technic for intubation and repeated short-duration anesthesia in the rat. Lab. An. 4, 75 (1970).CrossRefGoogle Scholar
  69. Negus, V.: Biology of respiration. Edinburgh, London: E. and S. Livingstone, LTD 1965.Google Scholar
  70. Nytch, T. F.: Clinical observations on the preanesthetic use of oxymorphine and its antagonist N-allyl-noroxymorphane, in dogs. J. Am. Vet. Med. Assoc. 145, 127 (1964).PubMedGoogle Scholar
  71. Orahovats, P. D., Lehman, E. G., Chapin, E. W.: Pharmacology of Ethyl-l-(4-aminophen- ethyl)-4-phenylisonipecotate, anileridine, a new potent synthetic analgesic. J. Pharmacol. Exptl. Therap. 119, 26 (1957).Google Scholar
  72. Orr, D., Jones, I.: Anesthesia for laryngoscopy. Current Researches Anesthesia & Analgesia 23, 194 (1968).Google Scholar
  73. Owen, L. N.: Thirambutene-thiopentone anesthesia for hysterectomy in pyometra of the bitch. Vet. Record 67, 580 (1955).Google Scholar
  74. Quentin, J. R. L., Siry, J. R.: Tranquillizers in veterinary medicine. Ag. Vet. Chem. 3, 136 (1962).Google Scholar
  75. Ratcliffe, H. L.: Diazepam (Tranimal) as a tranquillizer for zoo animals. Report Penrose Res. Lab. Zool. Soc. of Phila., 10, 1962.Google Scholar
  76. Redgate, J. D., Gellhorn, E.: The tonic effect of the posterior hypothalamus on blood pressure and pulse rate disclosed by the action of intra-hypothalamically injected drugs. Arch, intern, pharmacodynamic 105, 193 (1956).Google Scholar
  77. Remmen, E., Cohen, S., Ditman, K. S., Frantz, J. R.: Psychochemotherapy, the physicians manual, Chap. 4. Los Angeles, Calif.: Western Medical Publications 1962.Google Scholar
  78. Rex, M. A. E.: Stimulation of larynospasms in the cat by volatile anesthetics. Brit. J. Aneasthesia 38, 569 (1966).CrossRefGoogle Scholar
  79. Rex, M. A. E., The laryngeal reflex. New Zealand Vet. J. 15, 222 (1967).CrossRefGoogle Scholar
  80. Reynolds, A. K., Randall, L. O.: Morphine and allied drugs. Canada: University of Toronto Press 1957.Google Scholar
  81. Robbins, B. H.: Studies on cyclopropane IX. The effect of premedication with demerol upon the heart rate, rhythm and blood pressure in dogs under cyclopropane anesthesia. J. Pharmacol. Exptl Therap. 85, 198 (1945).Google Scholar
  82. Rubin, A. Winston, J.: The role of the vestibular apparatus in the production of nausea and vomiting following the administration of morphine to man. J. Clin. Invest. 29, 1261 (1950).PubMedCrossRefGoogle Scholar
  83. Sagner, G., Hoffmeister, F., Kroneberg, G.: Pharmacological basis of a new drug for analgesia, sedation and relaxation in veterinary medicine, Bayer Va 1470 or “Rompun”. Deut. tierärztl. Wochschr. 75, 565 (1968).Google Scholar
  84. Seal, U. S., Erickson, A. W.: Immobilization of Carnivora and other mammals with phencyclidine and promazine. Federation Proc. 28 (1969).Google Scholar
  85. Shemano, I., Wendel, H.: Effects of meperidine hydrochloride and morphine sulfate on the lung capacity of intact dogs. J. Pharmacol. Exptl Therap. 149, 379 (1965).Google Scholar
  86. Simmons, M. L., Smith, L. H.: An anesthetic unit for small laboratory animals. J. Appl. Physiol. 25, 324 (1968).PubMedGoogle Scholar
  87. Smith, T. C., Stephen, G. W., Zeiger, L., Wollman, H.: Effects of premedicant drugs on respiration and gas exchange in man. Anesthesiology 28, 883 (1967).PubMedCrossRefGoogle Scholar
  88. Smits, G. M.: Some experiments and experiences with neuroleptic and hypnotic drugs on ungulates with special regard to librium. Proc. of Fifth Internat. Symp. on Diseases of Zoo Animals. Royal Neth. Vet. Assoc., Ti; Dierg. 89, 195 (1964).Google Scholar
  89. Soma, L. R.: (Ed.): (1) Textbook of veterinary anesthesia Baltimore, Md.: Williams and Wilkins Co. 1971.Google Scholar
  90. Soma, L. R.: (Ed.): (2) Textbook of veterinary anesthesia, Chap. 21, Equipment and techniques for inhalation agents. Baltimore, Md.: Williams and Wilkins Co. 1971.Google Scholar
  91. Soma, L. R., Shields, D. R.: Neuroleptanalgesia produced by fentanyl and droperidol. J. Am. Vet. Med. Assoc. 145, 897 (1964).PubMedGoogle Scholar
  92. Stoliker, H. E.: The physiological and pharmacological effects of Sernylan: a review. Experimental Animal Anesthesiology, pp. 148–184. U.S. School of Aerospace Medicine, Aerospace Medical Division (AFSC), Brooks Air Force Base, San Antionio, Texas, July, 1965.Google Scholar
  93. Strobel, G. E., Wollman, H.: Pharmacology of anesthetic agents. Federation Proc. 28, 4 (1969).Google Scholar
  94. Sugioka, K., Boniface, K. J., Davis, D. A.: The influence of meperidine on myocardial contractility in the intact dog. Anesthesiology 18, 623 (1957).PubMedCrossRefGoogle Scholar
  95. Sykes, M. K.: Non-rebreathing valves. Brit. J. Anaesthesia 31, 450 (1959).CrossRefGoogle Scholar
  96. Tavernor, W. D.: An assessment of promazine hydrochloride as a sedative in the dog. Vet. Record 74, 779 (1962).Google Scholar
  97. Telivuo, L. J., Vaisanen, R.: Clinical experience with a phencyclidine derivative CI-581. Progress in Anesthesiology Proceedings of the Fourth World Congress of Anesthesiologists. London, 1968. Excerpta Med. Foundation, Amsterdam 1970.Google Scholar
  98. Tevik, A., Sharpe, J., Nelson, A. W., Berkely, W. E., Lumb, W. V.: Effect of nitrogen in a closed circle system with low oxygen flows for equine anesthesia. J. Am. Vet. Med. Assoc. 154, 166 (1969).PubMedGoogle Scholar
  99. V.A. Laboratory Guide: Comparative anesthesia in laboratory animals. Federation Proc. 28. 4 (1969).Google Scholar
  100. Vasko, J. S., Henney, R. P., Browley, R. K., Oldham, H. N., Morrow, A. G.: Effects of morphine on ventricular function and myocardial contractile force. J. Physiol. (London) 210, 329 (1966).Google Scholar
  101. Wang, S. C., Barison, H. L.: A new concept of organization of the central emetic mechanism. Gastroenterology 22, 1 (1952).PubMedGoogle Scholar
  102. Westhues, M., Fritsch, R.: Die Narkose der Tiere, Band I. Lokalanästhesie, Band II, Allgemeine Narkose. Berlin: Paul Parey 1961.Google Scholar
  103. Westhues, M., Fritsch, R., Animal anaesthesia: general, 1st ed. Philadelphia, Pennsylvania: J. B. Lippincott Co. 1965.Google Scholar

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Authors and Affiliations

  • L. R. Soma
  • H. W. Calderwood

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