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Exploratory and Newer Compounds

  • T. H. S. Burns
  • A. Bracken
Part of the Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology book series (HEP, volume 30)

Abstract

In writing a chapter on “Exploratory and Newer Compounds” in a book concerned with anesthesia, the authors feel that it is most important to have a clear idea of the aims of their work. The “Why?” must never be lost sight of, in the excitement of the “How ?”.

Keywords

Nitrous Oxide Boiling Point Vinyl Ether Sulphur Hexafluoride League Table 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aldrete, J. A., Virtue, R. W.: Prolonged inhalation of inert gases by rats. Anesthesia and Analgesia, Current Researches 46, 562–564 (1967); — Smith, B. E.: Discussion. Anesthesia and Analgesia, Current Researches 46, 564–565 (1967).Google Scholar
  2. Artusio, J. F., Jr., Van Poznak, A.: Laboratory and clinical investigation of teflurane, 1,1,1,2-tetrafluoro-2-bromoethane. Federation Proc. 20, (1) 312 (1961).Google Scholar
  3. Artusio, J. F., Jr., Van Poznak, A., Hunt, R. E., Tiers, F. M., Alexander, M.: A clinical evaluation of methoxyflurane in man. Anesthesiology 21, 512–517 (1960).PubMedCrossRefGoogle Scholar
  4. Banks, A. A., Campbell, A., Rudge, A. J.: Toxicity and narcotic activity of fluorocarbons. Nature 174, 885 (1954).CrossRefGoogle Scholar
  5. Banks, R. E., Ginsberg, A. E., Haszledine, R. N.: Heterocyclic polyfluoro-compounds — Part I. Pentafluoropyridine. J. Chem. Soc. 1961, 1740–1743.Google Scholar
  6. Barr, D. A.: Perfluoroalkyl derivatives of nitrogen. Part III. Heptafluoronitrosopropane, perfluoro-2-n propyl-l: 2 oxazetidine, perfluoro (methylene-n-propylamine), and related compounds. J. Chem. Soc. 1956, 3416–3428.Google Scholar
  7. Barr, D. A., Haszledine, R. N.: Perfluoroalkyl derivatives of nitrogen — Part I. Perfluoro-2-methyl- 1:2 oxazetidine and perfluoro (alkylene-alkylamines). J. Chem. Soc 1955, 1881–1889.Google Scholar
  8. Benson, S. W., King, J. W., Jr.: Electrostatic aspects of physical adsorption. Implications for molecular sieves and gaseous anesthesia. Science 150, 1710–1713 (1965).PubMedCrossRefGoogle Scholar
  9. Best, C. H., Taylor, N. B.: The physiological basis of medical practice, 6th Ed. p. 1220. Baltimore, Md.: Williams and Wilkins Comp. 1955.Google Scholar
  10. Bourne, J. G.: (1) Personal communication (1968).Google Scholar
  11. Bourne, J. G.: (2) The anaesthetic pressures of certain fluorine-containing gases. Brit. J. Anaesthesia 40, 142 (1968).CrossRefGoogle Scholar
  12. Bourne, J. G., Studies in anaesthetics including intravenous dental anaesthesia. London: Lloyd-Luke (Medical Books) Ltd. 1967.Google Scholar
  13. Bracken, A., Burns, T. H. S., Newland, D. S.: A trial of xenon as a non-explosive anaesthetic. Anaesthesia 11, 40–49 (1956).PubMedCrossRefGoogle Scholar
  14. Brennan, H. J., Hunter, A. R., Johnstone, M.: Halothane. A clinical assessment. Lancet 1957, II, 453–457.CrossRefGoogle Scholar
  15. BRINDLE, G. F., GILBERT, R. G. B., MILLAR, R. A.: The use of Fluothane in anaesthesia for neurosurgery: a preliminary report. Canad. Anaesth. J. 4, 265--281 (1957).Google Scholar
  16. Brindle, G. F., Gilbert, R. G. B., Millar, R. A.: The use of Fluothane in anaesthesia for neurosurgery: a preliminary report. Canad. Anaesth. J. 4, 265–281 (1957).CrossRefGoogle Scholar
  17. Burdon, J., Gilman, D. J., Patrick, C. R., Stacey, M., Tatlow, J. C.: Pentafluoropyridine. Nature 186, 231–232 (1960).CrossRefGoogle Scholar
  18. Burn, J. H., Epstein, H. G., Goodford, P. J.: The properties of the anaesthetic substance 1,1,2-trifluoro-l,2-dichloroethane. Brit. J. Anaesthesia 1959, 518–529.Google Scholar
  19. Burns, T. H. S.: (2) An investigation of new fluorine compounds in anaesthesia (3). The anaesthetic properties of hexafluorobenzene. Anaesthesia 16, 333–339 (1961).PubMedCrossRefGoogle Scholar
  20. Burns, T. H. S., (3) An investigation of new fluorine compounds in anaesthesia (4). Examination of an ethane and four ethers. Anaesthesia 16, 440–444 (1961).PubMedCrossRefGoogle Scholar
  21. Burns, T. H. S., Fluorine compounds in anaesthesia (5). Examination of six heavily halogenated aliphatic compounds. Anaesthesia 17, 337–343 (1962).PubMedCrossRefGoogle Scholar
  22. Burns, T. H. S., Fluorine compounds in anaesthesia (7). Examination of two derivatives of normal butane and nine heavily halogenated ring compounds. Anaesthesia 21, 42–50. (1966).PubMedCrossRefGoogle Scholar
  23. Burns, T. H. S., Unpublished data (1968).Google Scholar
  24. Burns, T. H. S., Hall, J. M., Bracken, A., Gouldstone, G.: Fluorine compounds in anaesthesia (6). Examination of fourteen heavily halogenated ring compounds. Anaesthesia 19, 167–176 (1964).PubMedCrossRefGoogle Scholar
  25. Burns, T. H. S., Hall, J. M., Bracken, A., Gouldstone, G., Newland, D. S.: (1) An investigation of new fluorine compounds in anaesthesia (1). Anaesthesia 16, 3–18 (1961).PubMedCrossRefGoogle Scholar
  26. Cascorbi, H. F., Krantz, J. C., Jr., Rudo, F. G.: Unpublished data (1962). Quoted in Krantz, J. C., Jr., Rudo, F. C. (q. v.) p. 538.Google Scholar
  27. Chapman, J., Hill, R., Mum, J., Suckling, C. W., Viney, D. J.: Impurities in halothane: their identities, concentrations and determination. J. Pharm. and Pharmacol. 19, 231–239 (1967).CrossRefGoogle Scholar
  28. Clayton, J. W.,Jr.: The mammalian toxicities of organic compounds containing fluorine. Handbook of Experimental Pharmacology, Vol. XX/I, p. 490. Berlin-Heidelberg-New York: Springer 1966.Google Scholar
  29. Clayton, J. W., Perfluorocyclobutane non-toxic. Chem. Eng. News 45, 8 (1967).Google Scholar
  30. Cullen, S. C., Gross, E. G.: The anaesthetic properties of xenon in animals and human beings, with additional observations on krypton. Science 113, 580–582 (1951).PubMedCrossRefGoogle Scholar
  31. Danishevskii, S. L., Kochanov, M. M.: Toxicity of some fluoro-organic compounds. Gigiena Truda I Professional. Zabolevaniya 5 (3), 3–8 (1961).Google Scholar
  32. Dobkin, A. B., Heinrich, R. G., Israel, J. S., Levy, A. A., Neville, J. F., Ounkasem, K.: Clinical and laboratory evaluation of a new inhalation agent: Compound 347 (CHF2 • O • CF2 • CHFC1). Anesthesiology 29, 275–287 (1968).PubMedCrossRefGoogle Scholar
  33. Dresdner, R. D., Young, J. A.: Some new sulphur bearing fluorocarbon derivatives. J. Am. Chem. Soc. 81, 574–577 (1959).CrossRefGoogle Scholar
  34. Duncan, W. A. M., Raventos, J.: The pharmacokinetics of halothane (Fluothane) anaesthesia. Brit. J. Anaesthesia 31, 302–315 (1959).CrossRefGoogle Scholar
  35. Eger, E. I., II: On the variation of anesthetic potency with vapor pressure. Anesthesiology 29, 1065–1066 (1968).PubMedCrossRefGoogle Scholar
  36. Eger, E. I., Brandstater, B., Saidman, L. J., Regan, M. J., Severinghaus, J. W., Munson, E. S.: Equipotent alveolar anesthetic concentrations of methoxyflurane, halothane, diethyl ether, fluroxene, cyclopropane, xenon and nitrous oxide in the dog. Anesthesiology 26, 771–777 (1965).PubMedCrossRefGoogle Scholar
  37. Englin, M. A., Makarov, S. T., Kruglyak, Yu. L., Moiseev, B. P., Videiko, A. F., Anisimova, A. N., Yakubovich, A. Ya.: Some reactions of alkyl difluoroamines. Zhur. ObshcheL Khim. 36, (11) 1966–1968 (1966).Google Scholar
  38. Forbes, A. M.: Halothane adrenaline and cardiac arrest. Anaesthesia 21, 22–27 (1966).PubMedCrossRefGoogle Scholar
  39. Forrester, A. C.: Mishaps in anaesthesia. Anaesthesia 14, 388–399 (1959).PubMedCrossRefGoogle Scholar
  40. Garmer, N. L., Leigh, J. M.: Some effects of hexafluorobenzene in cats. Brit. J. Pharmacol. 31, 345–350 (1967).PubMedGoogle Scholar
  41. Glover, J. H., Hodgson, H. W.: An investigation of new fluorine compounds in anaesthesia (2). Analysis by gas chromatography. Anaesthesia 16, 19–23 (1961).CrossRefGoogle Scholar
  42. Hall, L. W.: Private communication, 1968. School of Veterinary Medicine, Cambridge.Google Scholar
  43. Haszledine, R. N.: The fluorination of organic compounds containing nitrogen. J. Chem. Soc. 1950, 1966–1968.Google Scholar
  44. Imperial Smelting Co. Ltd. Unpublished work (1966).Google Scholar
  45. Karis, J. H., Gissen, A. J., Nastuk, W. L.: The effect of volatile anesthetic agents on neuromuscular transmission. Anesthesiology 28, 128–134 (1967).PubMedCrossRefGoogle Scholar
  46. Kober, E., Grundmann, C.: Triazines, XXII. Fluoro-s-triazines. J. Am. Chem. Soc. 81, 3769–3770 (1959).CrossRefGoogle Scholar
  47. Krantz, J. C.,Jr.: Carr, C. J., Lu, G., Bell, F. K.: Anesthesia XL. The anesthetic action of trifluoroethyl vinyl ether. J. Pharmacol. Exptl Therap. 108, 488–495 (1953).Google Scholar
  48. Krantz, J. C., Jr., Rudo, F. G.: The fluorinated anaesthetics. In: Handbook of Experimental Pharmacology, Vol. XX/I, p. 541. Berlin-Heidelberg-New York: Springer 1966.Google Scholar
  49. Lassen, H. C. A., Kenriksen, E., Neukirch, F., Kristensen, H. C.: Treatment of tetanus: severe bone marrow depression after prolonged nitrons oxide anaesthesia. Lancet 1956 I, 527–530.CrossRefGoogle Scholar
  50. Lu, G. G., Ling, J. S. L., Krantz, J. C., Jr.: Anesthesia XLI. The anesthetic properties of certain fluorinated hydrocarbons and ethers. Anesthesiology 14, 466–472 (1953).PubMedCrossRefGoogle Scholar
  51. Matheson: Perfluoro-2-butene. Matheson Gas Data Book, p. 353. California: The Matheson Company Inc. 1961.Google Scholar
  52. McAuliffe, C.: Solubility in water of paraffin, cycloparaffin, olefin, acetylene, cycloolefin, and aromatic hydrocarbons. J. Phys. Chem. 70, 1267–1275 (1966).CrossRefGoogle Scholar
  53. McDowell, S. A., Hall, K. D., Stephen, C. R.: Difluoromethyl-l,l,2-trifluoro-2-chloroethyl ether: Experiments on dogs with a new inhalational anaesthetic agent. Brit. J. Anaesthesia 40, 511–516 (1968).CrossRefGoogle Scholar
  54. Merkel, G., Eger, E. I., II: A comparative study of halothane and halopropropane anesthesia, including method for determining equipotency. Anesthesiology 24, 346–357 (1963).PubMedCrossRefGoogle Scholar
  55. Meyer, H. H.: Zur Theorie der Alkoholnarkose. Naunyn-Schmiedebergs Arch. Exptl Pathol, u. Pharmakol. 42, 109–118 (1899).Google Scholar
  56. Miller, K. W.: Brit. J. Anaesthesia 40, 142 (1968).CrossRefGoogle Scholar
  57. Miller, K. W., Paton, W. D. M., Smith, B. E.: The anaesthetic pressure of certain fluorine-containing gases. Brit. J. Anaesthesia 39, 910–918 (1967).CrossRefGoogle Scholar
  58. Miller, S. L.: Theory of gaseous anesthetics. Proc. Natl. Acad. Sci. US 47, 1515–1524 (1961).CrossRefGoogle Scholar
  59. Mullins, L. J.: Some physical mechanisms in narcosis. Chem. Revs 54, 289–323 (1954).CrossRefGoogle Scholar
  60. Nisbett, H. B.: Anaesthetics: The Royal Institute of Chemistry Monograph (3) (1949).Google Scholar
  61. Overton, E.: Studien iiber die Narkose. Jena 1901.Google Scholar
  62. Overton, E., Street, W. B.: Animals at very high pressures of helium and neon. Science 157, 97–98 (1967).CrossRefGoogle Scholar
  63. Parbrook, G. D.: The leucopenic effects of prolonged nitrous oxide treatment. Brit. J. Anesthesia 39, 119–127 (1967).CrossRefGoogle Scholar
  64. Pauling, L.: The hydrate microcrystal theory of general anaesthesia. Anesthesia and Analgesia, Current Researches 43, 1–10 (1961).Google Scholar
  65. Pittinger, C. B., Faulconer, A., Knott, J. R., Pender, J. W., Lucien Morris, E., Bickford, R. G.: Electroencephalographic and other observations in monkeys during xenon anaesthesia at elevated pressures. Anesthesiology 16, 551–563 (1955).PubMedCrossRefGoogle Scholar
  66. Raventos, J.: The action of Fluothane — a new volatile anaesthetic. Brit. J. Pharmacol. 11, 394–410 (1956).PubMedGoogle Scholar
  67. Raventos, J., Lemon, P. G.: The impurities in Fluothane. Their biological properties. Brit. J. Anaesthesia 37, 716–737 (1965).CrossRefGoogle Scholar
  68. Report of a working party on anaesthetic explosions. H.M. Stationery Office, London 1956.Google Scholar
  69. Robbins, B. H.: Preliminary studies of the anesthetic activity of fluorinated hydrocarbons. J. Pharmacol. Exptl Therap. 86, 197–204 (1946).Google Scholar
  70. Sachs, D. H.: On the variation of anesthetic potency with vapour pressure. Anesthesiology 29, 1064–1065 (1968).PubMedCrossRefGoogle Scholar
  71. Schön, G., Steen, H.: Explosion limits and ignition temperatures of some inhalational anaesthetics in mixtures with various oxygen carriers. Anaesthesist 17, 6–10 (1968).PubMedGoogle Scholar
  72. Schreiner, H. R.: Technical Report: the physiological effects of argon, helium and the rare gases. Tonawanda Research Laboratory and Clearinghouse, 1965.Google Scholar
  73. Seiflow, G. H.: The non-inflammability of Fluothane. Brit. J. Anaesthesia 29, 438–439 (1957).CrossRefGoogle Scholar
  74. Simmons, T. C., Hoffmann, F. W. with Beck, R. B., Holler, H. V., Katz,T., Kosher, R. J., Larson, E. R., Mulvaney, J. E., Paulson, K. E., Rogers, F. E., Singleton, B., Sparks, R. E.: Fluorocarbon derivatives. II. Cyclic Nitrides. J. Am. Chem. Soc. 79, 3429–3432 (1957).CrossRefGoogle Scholar
  75. Smith, B. E.: Discussion on “Prolonged inhalation of inert gases by rats”. (Aldrete and Virtue). Anesthesia and Analgesia, Current Researches 40, 564–565 (1967).Google Scholar
  76. Stier, A.: Trifluoroacetic acid as metabolite of halothane. Biochem. Pharmacol. 13, 1544 (1964).PubMedCrossRefGoogle Scholar
  77. Struck, H. C., Plattner, E. B.: A study of the pharmacological properties of certain saturated fluorocarbons. J. Pharmacol. Exptl Therap. 68, 217–219 (1940).Google Scholar
  78. Van Poznak, A., Artusio, J. F.,Jr.: Anesthetic properties of a series of fluorinated compounds. I. Fluorinated hydrocarbons. Toxicol. Appl. Pharmacol. 2, 363–373 (1960).CrossRefGoogle Scholar
  79. Virtue, R. W., Lund, L. O., Phelps, M.,Jr., Vogel, J. H. K., Beckwitt, H., Heron, M.: Difluoromethyl-l,l,2-trifluoro-2-chloroethyl ether as an anaesthetic agent: results with dogs and a preliminary note on observations with man. Canad. Anaesth. Soc. J. 13, 233–241 (1966).PubMedCrossRefGoogle Scholar
  80. Winek, C. L., Collom, W. C., Wecht, C. H.: Fatal benzene exposure by glue sniffing. Lancet 1967 I, 683.CrossRefGoogle Scholar
  81. Yakubovich, A. Ya., Sergeev, A. P., Fogel’zang, E. N.: Reaction of direct fluoroalkylenation. I. Synthesis of trifluorovinyl and chlorodifluorovinylamines. Zhur. Obshchei. Khim. 36 (7), 1317–1325 (1966).Google Scholar
  82. Young, J. A., Dresdner, R. D.: Fluorocarbon nitrogen compounds. II. Synthesis and properties of perfluorodimethylglycine, (CF3)2NCF2COOH. J. Am. Chem. Soc. 80, 1889 to 1892 (1958).CrossRefGoogle Scholar
  83. Young, J. A., Simmons, T. C., Hoffmann, F. W.: Fluorocarbon nitrogen compounds. I. Perfluoro- carbamic acid derivatives, amides, and oxazolidones. J. Am. Chem. Soc. 78, 5637–5639 (1956).Google Scholar

Copyright information

© Springer-Verlag/Berlin · Heidelberg 1972

Authors and Affiliations

  • T. H. S. Burns
  • A. Bracken

There are no affiliations available

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