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Biotransformation

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Modern Inhalation Anesthetics

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Abstract

The concept that anesthetics are biochemically inert and are eliminated from the body unchanged was held from the early work of Haggard (1924) until 1962 (van Dyke, 1963). Haggard studied the absorption, distribution, and elimination of diethyl ether and found that he could account for 87% of the anesthetic in the expired air. On this basis it was decided that anesthetics were not metabolized. Haggard’S techniques and studies were commendable but we now know that much of the 13% of unrecovered material had been metabolically altered.

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Authors
  1. Russell A. van Dyke
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Editors and Affiliations

  1. Biochemical Research Laboratory, The Dow Chemical Company, Midland, MI, 48640, USA

    Maynard B. Chenoweth

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© 1972 Springer-Verlag/Berlin · Heidelberg

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van Dyke, R.A. (1972). Biotransformation. In: Chenoweth, M.B. (eds) Modern Inhalation Anesthetics. Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65055-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-65055-0_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-65057-4

  • Online ISBN: 978-3-642-65055-0

  • eBook Packages: Springer Book Archive

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