Abstract
Next to oral ingestion, injection into subcutaneous or muscular tissue is by far the most commonly used route of drug administration. The evident advantages of parenteral injection are the reliability and precision of dosage and the generally rapid onset of action of the drug, while on the negative side must be counted discomforts and hazards such as tissue damage, pain and tenderness of the injected area and the risk of accidental injection of microorganisms.
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References
Ballard, B.E.: Biopharmaceutical considerations in subcutaneous and intramuscular drug administration. J. pharm. Sci. 57, 357–378 (1968).
Ballard, B.E., Menczel, E.: Subcutaneous absorption kinetics of benzyl alcohol. J. pharm. Sci. 56, 1476–1485 (1967).
Ballard, B.E. Nelson, E.: A simple, graphic method for estimating surface areas of subcutaneously implanted, cylindrical drug pellets. Amer. J. vet. Res. 23, 678–680 (1962a).
Ballard, B.E.,: Physicochemical properties of drugs that control absorption rate after subcutaneous implantation. J. Pharmacol. 135, 120–127 (1962b).
Ballard, B.E.: Prolonged action pharmaceuticals (Parenteral products, p. 627). In: Remington’s Pharmaceutical Sciences, 13. ed., pp. 612–640. Easton, Pa.: Mack Publ. Co. 1965.
Bay, E.: Technik und Gefahren der intramuskulären Injektion. Dtsch. med. Wschr. 92, 1950–1952 (1967).
Bederka, J.P., Miller, J.W., Takemori, A.E.: Absorption of drugs from skeletal muscle. Personal communication (1969).
Benitz, K.-F., Dambach, G.: Morphologic quantification of muscular lesions after injections of aqueous solutions. Arzneimittel.-Forsch. 16, 658–661 (1966).
Binder, CH.: Absorption of injected insulin. A clinical-pharmacological study. Acta Pharma¬col. (Kbh.) 27, Suppl. 2 (1969).
Braun, H.: Über den Einfluß der Vitalität der Gewebe auf die örtlichen und allgemeinen Giftwirkungen lokalanästhezierende Mittel und über die Bedeutung des Adrenalins für die Lokalanästhesie. Arch. klin. Chir. 69, 541–591 (1903).
Braun, H.: Die Lokalanästhesie, ihre wissenschaftlichen Grundlagen und praktische Anwendung. Leipzig: J.A. Barth 1905.
Calhoon, T.B., Gadsden, R.H.: Influence of connective tissue on swelling exhibited by musclesin vitro. Amer. J. Physiol. 202, 830–834 (1962).
Coates, F.C.: An insulin injection technique for preventing skin reactions. Amer. J. Nursing 65, 127–128 (1965).
Conley, B.E.: The new parenteral drugs of U.S.P. XVII. Bull. Parenteral Drug Ass. 16, 30 — 35 (1962).
Cutts, J.H., Walker, I.G.: The effect of pH upon the antitumor activity and toxicity of nitrogen mustard. Cancer Res. 26, 1386–1389 (1966).
Dost, F. H.: Der Blutspiegel. Kinetik der Konzentrationsabläufe in der Kreislaufflüssigkeit, pp. 224–251. Leipzig: Georg Thieme 1953.
Van Eck, D.J.H.M., Beks, J.W.F.: Lestel van de nervus radialis door intramusculaire injectie. Ned. T. Geneesk.112, 1021–1025 (1968).
Editorial: Sites for intramuscular injections. J. Pediat. 70, 158–159 (1967).
Foldes, F.F., Brown, I.M., Lunn, J.N.: The influence of solvent on the myoneural effects on intramuscular succinylcholine. Anesthesiology 23, 213–218 (1962).
Gangarosa, L.P., Cheong, D.K.: The effects of adrenergic drugs and blockers upon the efficiency of isotope clearance from the subcutaneous tissue of the cat. Arch. int. Pharma- codyn. 179, 425–433 (1969).
Garrod, L.P.: Choice of injection sites. Brit. med. J., 836 only (30 March 1968 ).
Griffenhagen, G.B.: The history of parenteral medication. Bull. Parenteral Drug Ass. 16, 12–19 (1962).
Guminska, I., Lisiak, W., Gembicki, W.: Rate of distribution of Na131I and of 131I-labelled albumin injected subcutaneously. Polish Med. J. 5, 303–310 (1967).
Harvey, P.W., Purnell, G.V.: Fatal case of gas gangrene associated with intramuscular injections. Brit. med. J. 744–746 (March 1968).
Howard-Jones, N.: A critical study of the origin and early development of hypodermic medication. J. Hist. Med. 2, 201–249 (1947).
Von Hochstetter, A.: Über die intraglutäale Injektion, ihre Komplikationen und deren Verhütung. Schweiz, med. Wschr. 84, 1226–1227 (1954).
Von Hochstetter, A.: Über Probleme und Technik der intraglutäalen Injektion, der Einfluß des Medikamentes und der Individualität des Patienten auf die Entstehung von Spritzenschäden. Schweiz, med. Wschr. 85, 1138–1144 (1955).
Hvidberg, E., Szporny, L., Langgard, H.: The composition of oedema fluid provoked in mice by oestradiol. Acta pharmacol. (Kbh.) 20, 243–252 (1963).
Jørgensen, A.E., Schou, J.: The local effect of cholinergic agents and Cholinesterase inhibition on the clearance of sucrose from muscles. Acta pharmacol. (Kbh.) 23, 205–212 (1965).
Kety, S.S.: Quantitative measurement of regional circulation by the clearance of radioactive sodium. Amer. J. med. Sci. 215, 352–353(1948).
Kety, S.S. Measurement of regional circulation by local clearance of radioactive sodium. Amer. Heart J. 38, 321–328 (1949).
Kety, S.S.: The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev. 3, 1–41 (1951).
Lassen, N. A., Lindbjerg, J., Munck, 0.: Measurement of blood-flow through skeletal muscle by intramuscular injection of Xenon-133. Lancet I, 686–689 (1964).
Macek, T.J.: Preparation of parenteral dispersions. J. pharm. Sci. 52, 694–699 (1963).
Malek, R.: Rétractions quadricipitales et injections intra-musculaires chez l’enfant. Ann. Chir. infant. (Paris) 7, 85–91 (1966).
Mazzia, V.D.B, and seven others: Radial nerve palsy from intramuscular injection. N.Y. State J. Med. 1674–1675 (May 15, 1962 ).
McMaster, P.D.: Intermittent take-up of fluid from cutaneous tissue. J. exp. Med. 73, 67–84 (1941a).
McMaster, P.D.: Factors influencing intermittent passage of Locke’s solution into living skin. J. exp. Med. 73, 85–108 (1941b).
McMaster, P. D.: Inquiry into structural conditions affecting fluid transport in interstitial tissue of skin. J. exp. Med. 74, 9–28 (1941c).
Medgyesi, G., Medgyesi, P.: Bemerkungen zur Pharmakokinetik eines intramuskulär verabreichten Medikaments. Pharmazie 22, 253–258 (1967).
Meyer, F., Holland, G.: Die Messung des Druckes in Geweben. Arch. exp. Pathol. Pharmakol. 168, 581–602 (1932).
Mogey, G.A.: Cetenary of hypodermic injection. Brit. med. J. 2, 1180–1185 (1953).
Mulligan, J.E., Cassee, G.E.: Clearance rate of 131iodine in mechanically injured and normal muscle tissue. Nursing Res. 14, 126–131 (1965).
Pappenheimer, J. R.: Passage of molecules through capillary walls. Physiol. Rev. 33, 387 to 423 (1953).
Pappenheimer, J. R., Renken, E.M., Borrero, L.M.: Filtration, diffusion and molecular sieving through peripheral capillary membranes; contribution to pore theory of capillary permeability. Amer. J. Physiol.167, 13–46 (1951).
Pappenheimer, J. R., Soto-Rivera, A.: Effective osmotic pressure of plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs. Amer. J. Physiol. 152, 471–491 (1948).
Perret, W.: Ist die intramuskuläre Einspritzung von Arzneimitteln am Arm eine gefährliche Behandlungsmethode ? Med. Klin. 1464–1466 (Nr. 34, 1962 ).
Pitel, M., Wemett, M.: The intramuscular injection. Amer. J. Nursing 64, 104–109 (April 1964).
Ramachandran, B.V., Ágren, G.: The retarding influence of atropine on absorption of radioactive diisopropylphosphofluoridate and radioactive inorganic phosphate in the rat. Acta pharmacol. (Kbh.) 20, 339–350 (1963).
Riggs, D.S.: The mathematical approach to physiological problems, pp. 161–163. Baltimore, Md.: Williams & Wilkins Co. 1963.
Roe, F.J.C.: The relevance of preclinical assessment of carcinogenesis. Clin. Pharmacol. Ther. 7, 77–111 (1966).
Rubbo, S.D., Gardner, J.F.: Skin preparation and intramuscular injections. Brit. med. J. 121–122 (July 13, 1968 ).
Schou, J.: Absorption of drugs from subcutaneous connective tissue. Pharmacol. Rev. 13, 441–464 (1961).
Schou, J.: A comparison of the potency of adrenaline and noradrenaline in delaying absorption from muscles. Acta pharmacol. (Kbh.) 26, 253–258 (1968).
Schriftman, H., Kondritzer, A.A.: Absorption of atropine from muscles. Amer. J. Physiol. 191, 591–594 (1957).
Secher-Hansen, E.: Studies on subcutaneous absorption in mice V: Absorption of water injected into the skin of normal and oestradiol-treated animals. Acta pharmacol. (Kbh.) 26, 229–239 (1968a).
Secher-Hansen, E.: Studies on the subcutaneous absorption in mice VI: Absorption of mannitol, sucrose, inulin and albumin in normal and oestradiol-treated animals. Acta pharmacol. (Kbh.) 26, 316–324 (1968 b).
Secher-Hansen, E.: Studies on the subcutaneous absorption in mice VII: Absorption of 3H20 and 14C-sucrose from non-buffered solutions at different pH values. Acta pharmacol. (Kbh.) 28, 97101 (1970a).
Secher-Hansen, E.: Studies on the subcutaneous absorption in mice VIII: Influence of connective tissue ground substance on the absorption of subcutaneously injected depots of sodium and chloride. Acta pharmacol. (Kbh.) 28, 102–107 (1970b).
Secher-Hansen, E.: Langgárd, H., Schou, J.: Studies on the subcutaneous absorption in mice I: A method for studying quantitatively the dynamics of subcutaneous absorption. Acta pharmacol. (Kbh.) 25, 162–168 (1967a).
Secher-Hansen, E.: Studies on the subcutaneous absorption in mice II: Influence of tonicity on the dynamics of subcutaneous absorption. Acta pharmacol. (Kbh.) 25, 290–298 (1967b).
Secher-Hansen, E.: Studies on the subcutaneous absorption in mice III: Aseptic inflammation following subcutaneous injections. Acta pharmacol. (Kbh.) 25, 299–306 (1967c).
Secher-Hansen, E.: Studies on the subcutaneous absorption in mice IV: Absorption of carbohydrates with different molecular weights from connective tissue. Acta pharmacol. (Kbh.) 26, 9–14 (1968).
Shintani, S., Yamazaki, M., Nakamura, M., Nakayama, I.: A new method to determine the irritation of drugs after intramuscular injection in rabbits. Toxicol, appl. Pharmacol. 11, 293 — 301 (1967).
Steen-Johnsen, J.: Intramuskulære injeksjoner hos barn. T. norske Laegeforen. 82, 895 to 897 (1962).
Sund, R.B., Schotu, J.: The determination of absorption rates from rat muscles: An experimental approach to kinetic descriptions. Acta pharmacol. (Kbh.) 21, 313–325 (1964a).
Sund, R.B., Schou, J.: Absorption of atropine: Anticholinergics as inhibitors of absorption from muscles. Acta pharmacol. (Kbh.) 21, 339–346 (1964b).
Sund, R.B., Schou, J.: Hyaluronidase as an accelerator of muscular absorption of water and water soluble compounds. Acta pharmacol. (Kbh.) 23, 194–204 (1965).
Teorell, T.: Kinetics of distribution of substances administered to the body. I. Arch. int. Pharmacodyn. 57, 205–225 (1937a).
Teorell, T.: Kinetics of distribution of substances administered to the body. I. Arch. int. Pharmacodyn. 57, 226–240 (1937b).
Wagner, J.G.: Biopharmaceutics: absorption aspects. J. pharm. Sci. 50, 359–387 (1961).
Wagner, J.G., Nelson, E.: Kinetic analysis of blood levels and urinary excretion in the absorption phase after single doses of drug. J. pharm. Sci. 53, 1392–1403 (1964).
White, L.P., Claflin, E.F.: The effect of pH upon the antitumor activity and delayed lethal toxicity of nitrogen mustard. J. Pharmacol, exp. Ther. 142, 265–274 (1963).
Wolf, I. J.: A two-stage “controlled” intramuscular injection technique. A method preventing troublesome and painful local reactions. Clin. Pediatr. 7, 230–231 (1968).
Wolf, I. J. Paterson, N.J.: Risk with intramuscular injections. Clin. Pediatr. 7, 26A–30A (1968).
Zelman, S.: Notes on techniques of intramuscular injection. The avoidance of needless pain and morbidity. Amer. J. med. Sci. 563–574 (May 1961).
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Schou, J. (1971). Subcutaneous and Intramuscular Injection of Drugs. In: Brodie, B.B., Gillette, J.R., Ackerman, H.S. (eds) Concepts in Biochemical Pharmacology. Handbuch der experimentellen Pharmakologie/Handbook of Experimental Pharmacology, vol 28 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65052-9_4
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DOI: https://doi.org/10.1007/978-3-642-65052-9_4
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