Abstract
Current investigations of the biosynthesis of connective tissue proteoglycans encompass a number of diverse aspects of this area, some of which are common to the study of biosynthetic processes in general, while others represent problems which are unique to the connective tissues. The scope of the field ranges from studies of individual enzyme reactions in cell-free systems to investigations of proteoglycan metabolism in the intact tissue or the whole animal under the influence of various metabolic regulators. In the limited space of this presentation, it is clearly impossible to cover all of these areas even in a superficial fashion. Emphasis will therefore be placed primarily on some recent developments in the study of individual enzymes participating in polysaccharide biosynthesis, especially the chain-initiating xylosyltransferase and other glycosyltransferases involved in the early stages of polysaccharide chain formation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baker, J.R., Rodén, L., Stoolmiller, A.C.: J. Biol. Chem. 247, 3838 (1972).
Baker, J.R., Rodén, L., Yamagata, S.: Biochem. J. 125, 93P (1971).
Baynes, J.W., Hsu, A.-F., Heath, E.C.: J. Biol. Chem. 248, 5693 (1973).
Behrens, N.H.: Abstracts of the Sixth Annual Miami Winter Symposia, p. 24. Department of Biochemistry, University of Miami 1973.
Behrens, N.H., Carminatti, H., Staneloni, R.J., Leloir, L.F., Cantarella, A.I.: Proc. Nat. Acad. Sci. U.S.A., in press.
Brew, K., Vanaman, T.C., Hill, R.L.: Proc. Nat. Acad. Sci. U.S.A. 50, 491 (1968).
Grebner, E.E., Hall, C.W., Neufeld, E.F.: Biochem. Biophys. Res. Commun. 22, 672 (1966a)
Grebner, E.E., Hall, C.W., Neufeld, E.F.: Arch. Biochem. Biophys. 116, 391 (1966b).
Hagopian, A., Eylar, E.H.: Arch. Biochem. Biophys. 128, 422 (1968).
Haug, A., Larsen, B.: Carbohydrate Res. 17, 297 (1971).
Heath, E.C., Baynes, J.W., Hsu, A.-F.: Abstracts of the Sixth Annual Miami Winter Symposia, p. 27, Department of Biochemistry, University of Miami 1973.
Helting, T.: J. Biol. Chem. 246, 815 (1971).
Helting, T.: J. Biol. Chem. 247, 4327 (1972).
Helting, T., Rodén, L.: J. Biol. Chem. 244, 2790 (1969).
Horwitz, A.L.: Ph. D. Thesis, University of Chicago, 1972.
Horwitz, A.L., Dorfman, A.: J. Cell Biol. 38, 358 (1968).
Jacobson, B., Davidson, E.A.: J. Biol. Chem. 237, 638 (1962).
Leloir, L.F., Staneloni, R.J., Carminatti, H., Behrens, N.H.: Biochem. Biophys. Res. Commun. 52, 1285 (1973).
Lindahl, U., Bäckström, G., Malmström, A., Fransson, L.-Ǻ.: Biochem. Biophys. Res. Commun. 46, 985 (1972).
Malmström, A., Fransson, L.-Ǻ.: FEBS Letters 16, 105 (1971).
Parodi, A.J., Behrens, N.H., Leloir, L.F., Carminatti, H.: Proc. Nat. Acad. Sci. U.S.A. 69, 3268 (1972).
Robinson, H.C., Telser, A., Dorfman, A.: Proc. Nat. Acad. Sci. U.S.A. 56, 1859 (1966).
Rodén, L.: In: Metabolic Conjugation and Metabolic Hydrolysis (Fishman, W.H., Ed.) Vol. II, p. 345–442. New York: Academic Press 1970.
Rodén, L., Baker, J.R., Helting, T., Schwartz, N.B., Stoolmiller, A.C., Yamagata, S., Yamagata, T.: Methods Enzymol. 28, 638 (1972).
Rothfield, L., Romeo, D.: In: Structure and Function of Biological Membranes (Rothfield, L.I., Ed.) p. 251–284. New York: Academic Press 1971.
Schachter, H., Rodén, L.: In: Metabolic Conjugation and Metabolic Hydrolysis (Fishman, W.H., Ed.) Vol. III, p. 1–149. New York: Academic Press 1972.
Schwartz, N.B., Rodén, L.: Fed. Proc. 31, 434Abs (1972).
Schwartz, N.B., Rodén, L.: Fed. Proc. 32, 560Abs (1973).
Schwartz, N.B., Rodén, L.: Carbohydrate Res., in press.
Schwartz, N.B., Rodén, L.: Submitted for publication (1974).
Schwartz, N.B., Rodén, L., Dorfman, A.: Biochem, Biophys. Res. Commun. 56, 717 (1974).
Stoolmiller, A.C., Dorfman, A.: In: Comprehensive Biochemistry (Florkin, M., Stotz, E.H., Eds.) Vol. 17, p. 241–275. Amsterdam: Elsevier 1969.
Stoolmiller, A.C., Dorfman, A.: J. Biol. Chem. 244, 236 (1969).
Stoolmiller, A.C., Horwitz, A.L., Dorfman, A.: J. Biol. Chem. 247, 3525 (1972).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Rodén, L., Schwartz, N.B. (1974). Biosynthesis of Connective Tissue Proteoglycans. In: Fricke, R., Hartmann, F. (eds) Connective Tissues. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61932-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-61932-8_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-61934-2
Online ISBN: 978-3-642-61932-8
eBook Packages: Springer Book Archive